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Molecularly imprinted polymers as specific adsorbents for zearalenone produced by precipitation polymerization and applied to mycotoxin production

Telusila Mausia, David De Smet UGent, Guorun Qu, Carlos Van Peteghem UGent, Dabing Zhang, Aibo Wu and Sarah De Saeger UGent (2011) ANALYTICAL LETTERS. 44(16). p.2633-2643
abstract
In this work, molecularly imprinted polymers (MIPs) using the mycotoxin zearalenone (ZEA) as template were first synthesized via precipitation polymerization and then applied as specific adsorbents in molecularly imprinted solid-phase extraction (MISPE) cartridges. The MISPE procedure was optimized with 3 mL of acetonitrile for preconditioning, 1 mL of acetonitrile:H(2)O (60:40) for loading, 1 mL of acetonitrile:H(2)O (30:70), and 3 mL of methanol:acetic acid (95:5) for elution. The obtained MIPs showed high selectivity of 96.9% towards ZEA, and low cross-reactivity (1-20%) to other Fusarium mycotoxins including deoxynivalenol, nivalenol, HT-2 toxin and T-2 toxin. The cross-reactivity to fumonisin B(1) amounted to 61%. The MISPE was applied for enrichment of ZEA, which was produced by Fusarium graminearum strains. An enrichment factor above 50 was reached. Recoveries of 1 mu g/mL were between 90.8% and 99.6%. A small amount of ZEA was produced by 9 F. graminearum strains with a maximum of 13 mu g, then purified by the developed MISPE and analyzed by LC-MS/MS.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FARM-ANIMALS, MAIZE, CONTAMINATION, SAMPLE PREPARATION, Zearalenone, SOLID-PHASE EXTRACTION, Precipitation polymerization, Mycotoxin production, Molecularly imprinted polymers, CORN, DETOXIFICATION, SORBENTS, CEREALS, PEPPER
journal title
ANALYTICAL LETTERS
Anal. Lett.
volume
44
issue
16
pages
2633 - 2643
Web of Science type
Article
Web of Science id
000296585900007
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
1.016 (2011)
JCR rank
53/73 (2011)
JCR quartile
3 (2011)
ISSN
0003-2719
DOI
10.1080/00032719.2011.553009
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1976911
handle
http://hdl.handle.net/1854/LU-1976911
date created
2012-01-03 14:12:19
date last changed
2012-01-16 14:57:48
@article{1976911,
  abstract     = {In this work, molecularly imprinted polymers (MIPs) using the mycotoxin zearalenone (ZEA) as template were first synthesized via precipitation polymerization and then applied as specific adsorbents in molecularly imprinted solid-phase extraction (MISPE) cartridges. The MISPE procedure was optimized with 3 mL of acetonitrile for preconditioning, 1 mL of acetonitrile:H(2)O (60:40) for loading, 1 mL of acetonitrile:H(2)O (30:70), and 3 mL of methanol:acetic acid (95:5) for elution. The obtained MIPs showed high selectivity of 96.9\% towards ZEA, and low cross-reactivity (1-20\%) to other Fusarium mycotoxins including deoxynivalenol, nivalenol, HT-2 toxin and T-2 toxin. The cross-reactivity to fumonisin B(1) amounted to 61\%. The MISPE was applied for enrichment of ZEA, which was produced by Fusarium graminearum strains. An enrichment factor above 50 was reached. Recoveries of 1 mu g/mL were between 90.8\% and 99.6\%. A small amount of ZEA was produced by 9 F. graminearum strains with a maximum of 13 mu g, then purified by the developed MISPE and analyzed by LC-MS/MS.},
  author       = {Mausia, Telusila and De Smet, David and Qu, Guorun and Van Peteghem, Carlos and Zhang, Dabing and Wu, Aibo and De Saeger, Sarah},
  issn         = {0003-2719},
  journal      = {ANALYTICAL LETTERS},
  keyword      = {FARM-ANIMALS,MAIZE,CONTAMINATION,SAMPLE PREPARATION,Zearalenone,SOLID-PHASE EXTRACTION,Precipitation polymerization,Mycotoxin production,Molecularly imprinted polymers,CORN,DETOXIFICATION,SORBENTS,CEREALS,PEPPER},
  language     = {eng},
  number       = {16},
  pages        = {2633--2643},
  title        = {Molecularly imprinted polymers as specific adsorbents for zearalenone produced by precipitation polymerization and applied to mycotoxin production},
  url          = {http://dx.doi.org/10.1080/00032719.2011.553009},
  volume       = {44},
  year         = {2011},
}

Chicago
Mausia, Telusila, David De Smet, Guorun Qu, Carlos Van Peteghem, Dabing Zhang, Aibo Wu, and Sarah De Saeger. 2011. “Molecularly Imprinted Polymers as Specific Adsorbents for Zearalenone Produced by Precipitation Polymerization and Applied to Mycotoxin Production.” Analytical Letters 44 (16): 2633–2643.
APA
Mausia, T., De Smet, D., Qu, G., Van Peteghem, C., Zhang, D., Wu, A., & De Saeger, S. (2011). Molecularly imprinted polymers as specific adsorbents for zearalenone produced by precipitation polymerization and applied to mycotoxin production. ANALYTICAL LETTERS, 44(16), 2633–2643.
Vancouver
1.
Mausia T, De Smet D, Qu G, Van Peteghem C, Zhang D, Wu A, et al. Molecularly imprinted polymers as specific adsorbents for zearalenone produced by precipitation polymerization and applied to mycotoxin production. ANALYTICAL LETTERS. 2011;44(16):2633–43.
MLA
Mausia, Telusila, David De Smet, Guorun Qu, et al. “Molecularly Imprinted Polymers as Specific Adsorbents for Zearalenone Produced by Precipitation Polymerization and Applied to Mycotoxin Production.” ANALYTICAL LETTERS 44.16 (2011): 2633–2643. Print.