Divergent synthetic approach to 6''-modified α-GalCer analogues
- Author
- Nora Pauwels (UGent) , SANDRINE ASPESLAGH (UGent) , Gerd Vanhoenacker, Koen Sandra, Esther D. Yu, Dirk M. Zajonc, Dirk Elewaut (UGent) , Bruno Linclau (UGent) and Serge Van Calenbergh (UGent)
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- Project
- Abstract
- A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.
- Keywords
- KRN7000, CELL STIMULATING PROPERTIES, KILLER T-CELLS, NKT CELLS, RHAMNOGALACTURONAN-I, GALACTOSYL CERAMIDE, RECOGNITION, GLYCOLIPIDS, PHASE-I, INKT CELLS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1976065
- MLA
- Pauwels, Nora, et al. “Divergent Synthetic Approach to 6"-Modified α-GalCer Analogues.” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, no. 24, 2011, pp. 8413–21, doi:10.1039/c1ob06235b.
- APA
- Pauwels, N., ASPESLAGH, S., Vanhoenacker, G., Sandra, K., Yu, E. D., Zajonc, D. M., … Van Calenbergh, S. (2011). Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(24), 8413–8421. https://doi.org/10.1039/c1ob06235b
- Chicago author-date
- Pauwels, Nora, SANDRINE ASPESLAGH, Gerd Vanhoenacker, Koen Sandra, Esther D. Yu, Dirk M. Zajonc, Dirk Elewaut, Bruno Linclau, and Serge Van Calenbergh. 2011. “Divergent Synthetic Approach to 6"-Modified α-GalCer Analogues.” ORGANIC & BIOMOLECULAR CHEMISTRY 9 (24): 8413–21. https://doi.org/10.1039/c1ob06235b.
- Chicago author-date (all authors)
- Pauwels, Nora, SANDRINE ASPESLAGH, Gerd Vanhoenacker, Koen Sandra, Esther D. Yu, Dirk M. Zajonc, Dirk Elewaut, Bruno Linclau, and Serge Van Calenbergh. 2011. “Divergent Synthetic Approach to 6"-Modified α-GalCer Analogues.” ORGANIC & BIOMOLECULAR CHEMISTRY 9 (24): 8413–8421. doi:10.1039/c1ob06235b.
- Vancouver
- 1.Pauwels N, ASPESLAGH S, Vanhoenacker G, Sandra K, Yu ED, Zajonc DM, et al. Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY. 2011;9(24):8413–21.
- IEEE
- [1]N. Pauwels et al., “Divergent synthetic approach to 6"-modified α-GalCer analogues,” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 9, no. 24, pp. 8413–8421, 2011.
@article{1976065,
abstract = {{A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.}},
author = {{Pauwels, Nora and ASPESLAGH, SANDRINE and Vanhoenacker, Gerd and Sandra, Koen and Yu, Esther D. and Zajonc, Dirk M. and Elewaut, Dirk and Linclau, Bruno and Van Calenbergh, Serge}},
issn = {{1477-0520}},
journal = {{ORGANIC & BIOMOLECULAR CHEMISTRY}},
keywords = {{KRN7000,CELL STIMULATING PROPERTIES,KILLER T-CELLS,NKT CELLS,RHAMNOGALACTURONAN-I,GALACTOSYL CERAMIDE,RECOGNITION,GLYCOLIPIDS,PHASE-I,INKT CELLS}},
language = {{eng}},
number = {{24}},
pages = {{8413--8421}},
title = {{Divergent synthetic approach to 6''-modified α-GalCer analogues}},
url = {{http://doi.org/10.1039/c1ob06235b}},
volume = {{9}},
year = {{2011}},
}
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