Advanced search
1 file | 437.96 KB

Divergent synthetic approach to 6''-modified α-GalCer analogues

(2011) ORGANIC & BIOMOLECULAR CHEMISTRY. 9(24). p.8413-8421
Author
Organization
Project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.
Keywords
KRN7000, CELL STIMULATING PROPERTIES, KILLER T-CELLS, NKT CELLS, RHAMNOGALACTURONAN-I, GALACTOSYL CERAMIDE, RECOGNITION, GLYCOLIPIDS, PHASE-I, INKT CELLS

Downloads

    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 437.96 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Pauwels, Nora, SANDRINE ASPESLAGH, Gerd Vanhoenacker, Koen Sandra, Esther D Yu, Dirk M Zajonc, Dirk Elewaut, Bruno Linclau, and Serge Van Calenbergh. 2011. “Divergent Synthetic Approach to 6"-modified α-GalCer Analogues.” Organic & Biomolecular Chemistry 9 (24): 8413–8421.
APA
Pauwels, Nora, ASPESLAGH, S., Vanhoenacker, G., Sandra, K., Yu, E. D., Zajonc, D. M., Elewaut, D., et al. (2011). Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(24), 8413–8421.
Vancouver
1.
Pauwels N, ASPESLAGH S, Vanhoenacker G, Sandra K, Yu ED, Zajonc DM, et al. Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY. 2011;9(24):8413–21.
MLA
Pauwels, Nora, SANDRINE ASPESLAGH, Gerd Vanhoenacker, et al. “Divergent Synthetic Approach to 6"-modified α-GalCer Analogues.” ORGANIC & BIOMOLECULAR CHEMISTRY 9.24 (2011): 8413–8421. Print.
@article{1976065,
  abstract     = {A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.},
  author       = {Pauwels, Nora and ASPESLAGH, SANDRINE and Vanhoenacker, Gerd and Sandra, Koen and Yu, Esther D and Zajonc, Dirk M and Elewaut, Dirk and Linclau, Bruno and Van Calenbergh, Serge},
  issn         = {1477-0520},
  journal      = {ORGANIC \& BIOMOLECULAR CHEMISTRY},
  keyword      = {KRN7000,CELL STIMULATING PROPERTIES,KILLER T-CELLS,NKT CELLS,RHAMNOGALACTURONAN-I,GALACTOSYL CERAMIDE,RECOGNITION,GLYCOLIPIDS,PHASE-I,INKT CELLS},
  language     = {eng},
  number       = {24},
  pages        = {8413--8421},
  title        = {Divergent synthetic approach to 6''-modified \ensuremath{\alpha}-GalCer analogues},
  url          = {http://dx.doi.org/10.1039/c1ob06235b},
  volume       = {9},
  year         = {2011},
}

Altmetric
View in Altmetric
Web of Science
Times cited: