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Divergent synthetic approach to 6''-modified α-GalCer analogues

Nora Pauwels UGent, SANDRINE ASPESLAGH UGent, Gerd Vanhoenacker, Koen Sandra, Esther D Yu, Dirk M Zajonc, Dirk Elewaut UGent, Bruno Linclau and Serge Van Calenbergh UGent (2011) ORGANIC & BIOMOLECULAR CHEMISTRY. 9(24). p.8413-8421
abstract
A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.
Please use this url to cite or link to this publication:
author
organization
alternative title
Divergent synthetic approach to 6 ''-modified alpha-GalCer analogues
year
type
journalArticle (original)
publication status
published
subject
keyword
KRN7000, CELL STIMULATING PROPERTIES, KILLER T-CELLS, NKT CELLS, RHAMNOGALACTURONAN-I, GALACTOSYL CERAMIDE, RECOGNITION, GLYCOLIPIDS, PHASE-I, INKT CELLS
journal title
ORGANIC & BIOMOLECULAR CHEMISTRY
Org. Biomol. Chem.
volume
9
issue
24
pages
8413 - 8421
Web of Science type
Article
Web of Science id
000297354100024
JCR category
CHEMISTRY, ORGANIC
JCR impact factor
3.696 (2011)
JCR rank
11/56 (2011)
JCR quartile
1 (2011)
ISSN
1477-0520
DOI
10.1039/c1ob06235b
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1976065
handle
http://hdl.handle.net/1854/LU-1976065
date created
2011-12-29 16:12:24
date last changed
2013-02-27 09:09:24
@article{1976065,
  abstract     = {A synthetic approach is presented for the synthesis of galacturonic acid and D-fucosyl modified KRN7000. The approach allows for late-stage functionalisation of both the sugar 6 ''-OH and the sphingosine amino groups, which enables convenient synthesis of promising 6 ''-modified KRN7000 analogues.},
  author       = {Pauwels, Nora and ASPESLAGH, SANDRINE and Vanhoenacker, Gerd and Sandra, Koen and Yu, Esther D and Zajonc, Dirk M and Elewaut, Dirk and Linclau, Bruno and Van Calenbergh, Serge},
  issn         = {1477-0520},
  journal      = {ORGANIC \& BIOMOLECULAR CHEMISTRY},
  keyword      = {KRN7000,CELL STIMULATING PROPERTIES,KILLER T-CELLS,NKT CELLS,RHAMNOGALACTURONAN-I,GALACTOSYL CERAMIDE,RECOGNITION,GLYCOLIPIDS,PHASE-I,INKT CELLS},
  language     = {eng},
  number       = {24},
  pages        = {8413--8421},
  title        = {Divergent synthetic approach to 6''-modified \ensuremath{\alpha}-GalCer analogues},
  url          = {http://dx.doi.org/10.1039/c1ob06235b},
  volume       = {9},
  year         = {2011},
}

Chicago
Pauwels, Nora, Sandrine Aspeslagh, Gerd Vanhoenacker, Koen Sandra, Esther D Yu, Dirk M Zajonc, Dirk Elewaut, Bruno Linclau, and Serge Van Calenbergh. 2011. “Divergent Synthetic Approach to 6"-modified α-GalCer Analogues.” Organic & Biomolecular Chemistry 9 (24): 8413–8421.
APA
Pauwels, Nora, Aspeslagh, S., Vanhoenacker, G., Sandra, K., Yu, E. D., Zajonc, D. M., Elewaut, D., et al. (2011). Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(24), 8413–8421.
Vancouver
1.
Pauwels N, Aspeslagh S, Vanhoenacker G, Sandra K, Yu ED, Zajonc DM, et al. Divergent synthetic approach to 6"-modified α-GalCer analogues. ORGANIC & BIOMOLECULAR CHEMISTRY. 2011;9(24):8413–21.
MLA
Pauwels, Nora, Sandrine Aspeslagh, Gerd Vanhoenacker, et al. “Divergent Synthetic Approach to 6"-modified α-GalCer Analogues.” ORGANIC & BIOMOLECULAR CHEMISTRY 9.24 (2011): 8413–8421. Print.