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Nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions

Vanessa Smith UGent, Filip De Keyser UGent, Carmen Pizzorni, JENS VAN PRAET UGent, Saskia Decuman UGent, Alberto Sulli, Ellen Deschepper UGent and Maurizio Cutolo (2011) ANNALS OF THE RHEUMATIC DISEASES. 70(1). p.180-183
abstract
Objective Construction of a simple nailfold videocapillaroscopic (NVC) scoring modality as a prognostic index for digital trophic lesions for day-to-day clinical use. Methods An association with a single simple (semi)quantitatively scored NVC parameter, mean score of capillary loss, was explored in 71 consecutive patients with systemic sclerosis (SSc), and reliable reduction in the number of investigated fields (F32-F16-F8-F4). The cut-off value of the prognostic index (mean score of capillary loss calculated over a reduced number of fields) for present/future digital trophic lesions was selected by receiver operating curve (ROC) analysis. Results Reduction in the number of fields for mean score of capillary loss was reliable from F32 to F8 (intraclass correlation coefficient of F16/F32: 0.97; F8/F32: 0.90). Based on ROC analysis, a prognostic index (mean score of capillary loss as calculated over F8) with a cut-off value of 1.67 is proposed. This value has a sensitivity of 72.22/70.00, specificity of 70.59/69.77, positive likelihood ratio of 2.46/2.32 and a negative likelihood ratio of 0.39/0.43 for present/future digital trophic lesions. Conclusions A simple prognostic index for digital trophic lesions for daily use in SSc clinics is proposed, limited to the mean score of capillary loss as calculated over eight fields (8 fingers, 1 field per finger).
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SEVERITY, SYSTEMIC-SCLEROSIS PATIENTS, RAYNAUDS-PHENOMENON, SCLERODERMA, VIDEOCAPILLAROSCOPY ASSESSMENT
journal title
ANNALS OF THE RHEUMATIC DISEASES
Ann. Rheum. Dis.
volume
70
issue
1
pages
180 - 183
Web of Science type
Article
Web of Science id
000285381100031
JCR category
RHEUMATOLOGY
JCR impact factor
8.727 (2011)
JCR rank
1/29 (2011)
JCR quartile
1 (2011)
ISSN
0003-4967
DOI
10.1136/ard.2010.132431
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1975106
handle
http://hdl.handle.net/1854/LU-1975106
date created
2011-12-29 09:08:42
date last changed
2012-01-04 10:07:23
@article{1975106,
  abstract     = {Objective Construction of a simple nailfold videocapillaroscopic (NVC) scoring modality as a prognostic index for digital trophic lesions for day-to-day clinical use. 
Methods An association with a single simple (semi)quantitatively scored NVC parameter, mean score of capillary loss, was explored in 71 consecutive patients with systemic sclerosis (SSc), and reliable reduction in the number of investigated fields (F32-F16-F8-F4). The cut-off value of the prognostic index (mean score of capillary loss calculated over a reduced number of fields) for present/future digital trophic lesions was selected by receiver operating curve (ROC) analysis. 
Results Reduction in the number of fields for mean score of capillary loss was reliable from F32 to F8 (intraclass correlation coefficient of F16/F32: 0.97; F8/F32: 0.90). Based on ROC analysis, a prognostic index (mean score of capillary loss as calculated over F8) with a cut-off value of 1.67 is proposed. This value has a sensitivity of 72.22/70.00, specificity of 70.59/69.77, positive likelihood ratio of 2.46/2.32 and a negative likelihood ratio of 0.39/0.43 for present/future digital trophic lesions. 
Conclusions A simple prognostic index for digital trophic lesions for daily use in SSc clinics is proposed, limited to the mean score of capillary loss as calculated over eight fields (8 fingers, 1 field per finger).},
  author       = {Smith, Vanessa and De Keyser, Filip and Pizzorni, Carmen and VAN PRAET, JENS and Decuman, Saskia and Sulli, Alberto and Deschepper, Ellen and Cutolo, Maurizio},
  issn         = {0003-4967},
  journal      = {ANNALS OF THE RHEUMATIC DISEASES},
  keyword      = {SEVERITY,SYSTEMIC-SCLEROSIS PATIENTS,RAYNAUDS-PHENOMENON,SCLERODERMA,VIDEOCAPILLAROSCOPY ASSESSMENT},
  language     = {eng},
  number       = {1},
  pages        = {180--183},
  title        = {Nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions},
  url          = {http://dx.doi.org/10.1136/ard.2010.132431},
  volume       = {70},
  year         = {2011},
}

Chicago
SMITH, VANESSA, Filip De Keyser, Carmen Pizzorni, JENS VAN PRAET, Saskia Decuman, Alberto Sulli, Ellen Deschepper, and Maurizio Cutolo. 2011. “Nailfold Capillaroscopy for Day-to-day Clinical Use: Construction of a Simple Scoring Modality as a Clinical Prognostic Index for Digital Trophic Lesions.” Annals of the Rheumatic Diseases 70 (1): 180–183.
APA
SMITH, V., De Keyser, F., Pizzorni, C., VAN PRAET, J., Decuman, S., Sulli, A., Deschepper, E., et al. (2011). Nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions. ANNALS OF THE RHEUMATIC DISEASES, 70(1), 180–183.
Vancouver
1.
SMITH V, De Keyser F, Pizzorni C, VAN PRAET J, Decuman S, Sulli A, et al. Nailfold capillaroscopy for day-to-day clinical use: construction of a simple scoring modality as a clinical prognostic index for digital trophic lesions. ANNALS OF THE RHEUMATIC DISEASES. 2011;70(1):180–3.
MLA
SMITH, VANESSA, Filip De Keyser, Carmen Pizzorni, et al. “Nailfold Capillaroscopy for Day-to-day Clinical Use: Construction of a Simple Scoring Modality as a Clinical Prognostic Index for Digital Trophic Lesions.” ANNALS OF THE RHEUMATIC DISEASES 70.1 (2011): 180–183. Print.