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Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study

JENS VAN PRAET UGent, Vanessa Smith UGent, Marc Haspeslagh UGent, Nele Degryse UGent, Dirk Elewaut UGent and Filip De Keyser UGent (2011) ARTHRITIS RESEARCH & THERAPY. 13(1).
abstract
Introduction: The aims of the present study were to identify histopathological parameters which are linked to local clinical skin disease at two distinct anatomical sites in systemic sclerosis (SSc) patients with skin involvement (limited cutaneous systemic sclerosis (lcSSc) or diffuse cutaneous systemic sclerosis (dcSSc)) and to determine the sensitivity of SSc specific histological alterations, focusing on SSc patients without clinical skin involvement (limited SSc (lSSc)). Methods: Histopathological alterations were systematically scored in skin biopsies of 53 consecutive SSc patients (dorsal forearm and upper inner arm) and 18 controls (upper inner arm). Clinical skin involvement was evaluated using the modified Rodnan skin score. In patients with lcSSc or dcSSc, associations of histopathological parameters with local clinical skin involvement were determined by generalised estimation equation modelling. Results: The hyalinised collagen score, the myofibroblast score, the mean epidermal thickness, the mononuclear cellular infiltration and the frequency of focal exocytosis differed significantly between biopsies with and without local clinical skin involvement. Except for mononuclear cellular infiltration, all of the continuous parameters correlated with the local clinical skin score at the dorsal forearm. Parakeratosis, myofibroblasts and intima proliferation were present in a minority of the SSc biopsies, but not in controls. No differences were found between lSSc and controls. Conclusions: Several histopathological parameters are linked to local clinical skin disease. SSc-specific histological alterations have a low diagnostic sensitivity.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SCLERODERMA, SKIN, CLASSIFICATION, DISEASE, CRITERIA
journal title
ARTHRITIS RESEARCH & THERAPY
Arthritis Res. Ther.
volume
13
issue
1
article_number
R35
pages
7 pages
Web of Science type
Article
Web of Science id
000289523500046
JCR category
RHEUMATOLOGY
JCR impact factor
4.445 (2011)
JCR rank
7/29 (2011)
JCR quartile
1 (2011)
ISSN
1478-6354
DOI
10.1186/ar3267
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1975095
handle
http://hdl.handle.net/1854/LU-1975095
date created
2011-12-29 09:03:35
date last changed
2013-02-27 09:09:22
@article{1975095,
  abstract     = {Introduction: The aims of the present study were to identify histopathological parameters which are linked to local clinical skin disease at two distinct anatomical sites in systemic sclerosis (SSc) patients with skin involvement (limited cutaneous systemic sclerosis (lcSSc) or diffuse cutaneous systemic sclerosis (dcSSc)) and to determine the sensitivity of SSc specific histological alterations, focusing on SSc patients without clinical skin involvement (limited SSc (lSSc)). 
Methods: Histopathological alterations were systematically scored in skin biopsies of 53 consecutive SSc patients (dorsal forearm and upper inner arm) and 18 controls (upper inner arm). Clinical skin involvement was evaluated using the modified Rodnan skin score. In patients with lcSSc or dcSSc, associations of histopathological parameters with local clinical skin involvement were determined by generalised estimation equation modelling. 
Results: The hyalinised collagen score, the myofibroblast score, the mean epidermal thickness, the mononuclear cellular infiltration and the frequency of focal exocytosis differed significantly between biopsies with and without local clinical skin involvement. Except for mononuclear cellular infiltration, all of the continuous parameters correlated with the local clinical skin score at the dorsal forearm. Parakeratosis, myofibroblasts and intima proliferation were present in a minority of the SSc biopsies, but not in controls. No differences were found between lSSc and controls. 
Conclusions: Several histopathological parameters are linked to local clinical skin disease. SSc-specific histological alterations have a low diagnostic sensitivity.},
  articleno    = {R35},
  author       = {VAN PRAET, JENS and Smith, Vanessa and Haspeslagh, Marc and Degryse, Nele and Elewaut, Dirk and De Keyser, Filip},
  issn         = {1478-6354},
  journal      = {ARTHRITIS RESEARCH \& THERAPY},
  keyword      = {SCLERODERMA,SKIN,CLASSIFICATION,DISEASE,CRITERIA},
  language     = {eng},
  number       = {1},
  pages        = {7},
  title        = {Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study},
  url          = {http://dx.doi.org/10.1186/ar3267},
  volume       = {13},
  year         = {2011},
}

Chicago
VAN PRAET, JENS, VANESSA SMITH, Marc Haspeslagh, Nele Degryse, Dirk Elewaut, and Filip De Keyser. 2011. “Histopathological Cutaneous Alterations in Systemic Sclerosis: a Clinicopathological Study.” Arthritis Research & Therapy 13 (1).
APA
VAN PRAET, J., SMITH, V., Haspeslagh, M., Degryse, N., Elewaut, D., & De Keyser, F. (2011). Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study. ARTHRITIS RESEARCH & THERAPY, 13(1).
Vancouver
1.
VAN PRAET J, SMITH V, Haspeslagh M, Degryse N, Elewaut D, De Keyser F. Histopathological cutaneous alterations in systemic sclerosis: a clinicopathological study. ARTHRITIS RESEARCH & THERAPY. 2011;13(1).
MLA
VAN PRAET, JENS, VANESSA SMITH, Marc Haspeslagh, et al. “Histopathological Cutaneous Alterations in Systemic Sclerosis: a Clinicopathological Study.” ARTHRITIS RESEARCH & THERAPY 13.1 (2011): n. pag. Print.