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Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population

(2011) RHEUMATOLOGY. 50(11). p.1976-1981
Author
Organization
Abstract
Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population. Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (SNP) was selected as genetic marker and genotyped using Taqman 5' allelic discrimination assay. Results. The MIF -173 SNP showed association with SSc [P = 0.04, odds ratio (OR) = 1.10, 95% CI 1.00, 1.19]. Analysis of the MIF -173 polymorphism according to SSc clinical phenotype revealed that the frequency of the -173*C allele was significantly higher in the dcSSc group compared with controls (P = 5.30E-03, OR = 1.21, 95% CI 1.07, 1.38). Conversely, the frequency of the MIF -173*C allele was significantly underrepresented in the lcSSc group compared with dcSSc patients, supporting previous findings [(P = 0.04, OR = 0.86, 95% CI 0.75, 0.99); meta-analysis including previous results (P = 0.005, OR = 0.83, 95% CI 0.73, 0.94)]. Conclusion. Our results confirm the role of MIF -173 promoter polymorphism in SSc, and provide evidence of a strong association with the dcSSc subgroup of patients. Hence, the MIF -173 variant is confirmed as a promising clinical phenotype genetic marker.
Keywords
Scleroderma, Macrophage migration inhibitory factor, Systemic sclerosis, POLYMORPHISMS, MIF, SUSCEPTIBILITY, SCLERODERMA, EXPRESSION, ARTHRITIS, INFLAMMATORY-BOWEL-DISEASE, Polymorphisms

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MLA
Bossini-Castillo, Lara, Carmen P Simeon, Lorenzo Beretta, et al. “Confirmation of Association of the Macrophage Migration Inhibitory Factor Gene with Systemic Sclerosis in a Large European Population.” RHEUMATOLOGY 50.11 (2011): 1976–1981. Print.
APA
Bossini-Castillo, L., Simeon, C. P., Beretta, L., Vonk, M. C., Callejas-Rubio, J. L., Espinosa, G., Carreira, P., et al. (2011). Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. RHEUMATOLOGY, 50(11), 1976–1981.
Chicago author-date
Bossini-Castillo, Lara, Carmen P Simeon, Lorenzo Beretta, Madelon C Vonk, José Luis Callejas-Rubio, Gerard Espinosa, Patricia Carreira, et al. 2011. “Confirmation of Association of the Macrophage Migration Inhibitory Factor Gene with Systemic Sclerosis in a Large European Population.” Rheumatology 50 (11): 1976–1981.
Chicago author-date (all authors)
Bossini-Castillo, Lara, Carmen P Simeon, Lorenzo Beretta, Madelon C Vonk, José Luis Callejas-Rubio, Gerard Espinosa, Patricia Carreira, María T Camps, Luis Rodríguez-Rodríguez, Mónica Rodríuez-Carballeira, Francisco J García-Hernández, Francisco J López-Longo, Vanessa Hernández-Hernández, Luis Sáez-Comet, María Victoria Egurbide, Roger Hesselstrand, Annika Nordin, Anna-Maria Hoffmann-Vold, Marie Vanthuyne, Vanessa Smith, Ellen De Langhe, Alexander Kreuter, Gabriela Riemekasten, Torsten Witte, Nicolas Hunzelmann, Alexandre E Voskuyl, Annemie J Schuerwegh, Claudio Lunardi, Paolo Airó, Raffaella Scorza, Paul Shiels, Jacob M van Laar, Carmen Fonseca, Christopher Denton, Ariane Herrick, Jane Worthington, Bobby P Koeleman, Blanca Rueda, Timothy RDJ Radstake, and Javier Martin. 2011. “Confirmation of Association of the Macrophage Migration Inhibitory Factor Gene with Systemic Sclerosis in a Large European Population.” Rheumatology 50 (11): 1976–1981.
Vancouver
1.
Bossini-Castillo L, Simeon CP, Beretta L, Vonk MC, Callejas-Rubio JL, Espinosa G, et al. Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population. RHEUMATOLOGY. 2011;50(11):1976–81.
IEEE
[1]
L. Bossini-Castillo et al., “Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population,” RHEUMATOLOGY, vol. 50, no. 11, pp. 1976–1981, 2011.
@article{1974699,
  abstract     = {Objectives. The aim of this study was to confirm the implication of macrophage migration inhibitory factor (MIF) gene in SSc susceptibility or clinical phenotypes in a large European population. 
Methods. A total of 3800 SSc patients and 4282 healthy controls of white Caucasian ancestry from eight different European countries were included in the study. The MIF -173 single nucleotide polymorphism (SNP) was selected as genetic marker and genotyped using Taqman 5' allelic discrimination assay. 
Results. The MIF -173 SNP showed association with SSc [P = 0.04, odds ratio (OR) = 1.10, 95% CI 1.00, 1.19]. Analysis of the MIF -173 polymorphism according to SSc clinical phenotype revealed that the frequency of the -173*C allele was significantly higher in the dcSSc group compared with controls (P = 5.30E-03, OR = 1.21, 95% CI 1.07, 1.38). Conversely, the frequency of the MIF -173*C allele was significantly underrepresented in the lcSSc group compared with dcSSc patients, supporting previous findings [(P = 0.04, OR = 0.86, 95% CI 0.75, 0.99); meta-analysis including previous results (P = 0.005, OR = 0.83, 95% CI 0.73, 0.94)]. 
Conclusion. Our results confirm the role of MIF -173 promoter polymorphism in SSc, and provide evidence of a strong association with the dcSSc subgroup of patients. Hence, the MIF -173 variant is confirmed as a promising clinical phenotype genetic marker.},
  author       = {Bossini-Castillo, Lara and Simeon, Carmen P and Beretta, Lorenzo and Vonk, Madelon C and Callejas-Rubio, José Luis and Espinosa, Gerard and Carreira, Patricia and Camps, María T and Rodríguez-Rodríguez, Luis and Rodríuez-Carballeira, Mónica and García-Hernández, Francisco J and López-Longo, Francisco J and Hernández-Hernández, Vanessa and Sáez-Comet, Luis and Egurbide, María Victoria and Hesselstrand, Roger and Nordin, Annika and Hoffmann-Vold, Anna-Maria and Vanthuyne, Marie and Smith, Vanessa and De Langhe, Ellen and Kreuter, Alexander and Riemekasten, Gabriela and Witte, Torsten and Hunzelmann, Nicolas and Voskuyl, Alexandre E and Schuerwegh, Annemie J and Lunardi, Claudio and Airó, Paolo and Scorza, Raffaella and Shiels, Paul and van Laar, Jacob M and Fonseca, Carmen and Denton, Christopher and Herrick, Ariane and Worthington, Jane and Koeleman, Bobby P and Rueda, Blanca and Radstake, Timothy RDJ and Martin, Javier},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {Scleroderma,Macrophage migration inhibitory factor,Systemic sclerosis,POLYMORPHISMS,MIF,SUSCEPTIBILITY,SCLERODERMA,EXPRESSION,ARTHRITIS,INFLAMMATORY-BOWEL-DISEASE,Polymorphisms},
  language     = {eng},
  number       = {11},
  pages        = {1976--1981},
  title        = {Confirmation of association of the macrophage migration inhibitory factor gene with systemic sclerosis in a large European population},
  url          = {http://dx.doi.org/10.1093/rheumatology/ker259},
  volume       = {50},
  year         = {2011},
}

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