Ghent University Academic Bibliography

Advanced

The histological evaluation of osseointegration of surface enhanced microimplants immediately loaded in conjunction with sinuslifting in humans

HILDE BROWAEYS UGent, Stefan Vandeweghe UGent, Carina B Johansson, Ryo Jimbo, Ellen Deschepper UGent and Hugo De Bruyn UGent (2013) CLINICAL ORAL IMPLANTS RESEARCH. 24(1). p.36-44
abstract
Objective: The aim was to investigate histomorphometrically whether or not implant surface nanotopography improves the bone response under immediate loading simultaneous to sinus grafting. Materials and methods: Dual acid-etched titanium microimplants with/without crystalline surface deposition of calcium phosphate particles were placed in bilateral sinuslift areas grafted with a mixture of iliac crest bone and BioOss. Surface topography of microimplants was characterized using interferometry. Loaded microimplants (MsL) were immobilized in a provisional bridge supported by four normal size implants. Some patients had unloaded microimplants as controls (MsU). Biopsies were trephined after 2 or 4 months and histomorphometric analysis of bone area (BA) and bone-to-implant contact (BC) was performed. Nonparametric methods for dependent data were used to compare effect of surface modification, and healing time (2 vs. 4 months). Results: A total of 53 biopsies were available from 13 patients. A total of 4/28 and 1/11 MsL failed after resp. 2 and 4 months vs. 0/6 and 1/5 MsU. Many loaded biopsies were damaged at the apical portion and showed no bone adhesion MsL decreased in BA from coronal to apical from 2 to 4 months; Coronal > Middle (P = 0.047), Coronal > Apical (P < 0.001) and Middle > Apical (P < 0.001). This gradual decrease was not observed for BC; Coronal < Middle and Middle > Apical (P < 0.001). Only the middle part showed significant bone contact after 2 months. For MsL there was no statistically significant difference between surface or time indicating that improvement of osseointegration over time due to maturation of the graft was poor. The MsU did not show any difference between Osseotite and Nanotite for BIC and BA (P > 0.05) but doubled both their BA and BIC (P < 0.05) between 2 and 4 months. Conclusions: Osseointegration in sinus-grafted bone mixed with BioOss was poor irrespective of healing time or nanotopographical surface modification. The apex of MsL showed minimal bone contact suggesting that the graft does not add to the loading capacity. Surface enhancement was not beneficial despite the enlarged surface area. Overloading, most critical coronally of an implant, increases risks for implant failure and jeopardizes bone healing especially under immediate loading conditions with high load.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
histomorphometry, immediate loading, sinus floor elevation, sinuslifting, titanium implantion, surface modification, RETAINED MANDIBULAR OVERDENTURES, TIOBLAST DENTAL IMPLANTS, SINUS FLOOR AUGMENTATION, HUMAN POSTERIOR MAXILLA, UP CLINICAL REPORT, FOLLOW-UP, HISTOMORPHOMETRIC EVALUATION, RADIOGRAPHIC EVALUATION, TITANIUM MICROIMPLANTS, EDENTULOUS PATIENTS
journal title
CLINICAL ORAL IMPLANTS RESEARCH
Clin. Oral Implants Res.
volume
24
issue
1
pages
36 - 44
Web of Science type
Article
Web of Science id
000312814800006
JCR category
DENTISTRY, ORAL SURGERY & MEDICINE
JCR impact factor
3.123 (2013)
JCR rank
4/83 (2013)
JCR quartile
1 (2013)
ISSN
0905-7161
DOI
10.1111/j.1600-0501.2011.02398.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1974620
handle
http://hdl.handle.net/1854/LU-1974620
date created
2011-12-28 12:22:51
date last changed
2013-07-09 11:44:41
@article{1974620,
  abstract     = {Objective: The aim was to investigate histomorphometrically whether or not implant surface nanotopography improves the bone response under immediate loading simultaneous to sinus grafting.
Materials and methods: Dual acid-etched titanium microimplants with/without crystalline surface deposition of calcium phosphate particles were placed in bilateral sinuslift areas grafted with a mixture of iliac crest bone and BioOss. Surface topography of microimplants was characterized using interferometry. Loaded microimplants (MsL) were immobilized in a provisional bridge supported by four normal size implants. Some patients had unloaded microimplants as controls (MsU). Biopsies were trephined after 2 or 4 months and histomorphometric analysis of bone area (BA) and bone-to-implant contact (BC) was performed. Nonparametric methods for dependent data were used to compare effect of surface modification, and healing time (2 vs. 4 months). 
Results: A total of 53 biopsies were available from 13 patients. A total of 4/28 and 1/11 MsL failed after resp. 2 and 4 months vs. 0/6 and 1/5 MsU. Many loaded biopsies were damaged at the apical portion and showed no bone adhesion MsL decreased in BA from coronal to apical from 2 to 4 months; Coronal {\textrangle} Middle (P = 0.047), Coronal {\textrangle} Apical (P {\textlangle} 0.001) and Middle {\textrangle} Apical (P {\textlangle} 0.001). This gradual decrease was not observed for BC; Coronal {\textlangle} Middle and Middle {\textrangle} Apical (P {\textlangle} 0.001). Only the middle part showed significant bone contact after 2 months. For MsL there was no statistically significant difference between surface or time indicating that improvement of osseointegration over time due to maturation of the graft was poor. The MsU did not show any difference between Osseotite and Nanotite for BIC and BA (P {\textrangle} 0.05) but doubled both their BA and BIC (P {\textlangle} 0.05) between 2 and 4 months.
Conclusions: Osseointegration in sinus-grafted bone mixed with BioOss was poor irrespective of healing time or nanotopographical surface modification. The apex of MsL showed minimal bone contact suggesting that the graft does not add to the loading capacity. Surface enhancement was not beneficial despite the enlarged surface area. Overloading, most critical coronally of an implant, increases risks for implant failure and jeopardizes bone healing especially under immediate loading conditions with high load.},
  author       = {BROWAEYS, HILDE and Vandeweghe, Stefan and Johansson, Carina B and Jimbo, Ryo  and Deschepper, Ellen and De Bruyn, Hugo},
  issn         = {0905-7161},
  journal      = {CLINICAL ORAL IMPLANTS RESEARCH},
  keyword      = {histomorphometry,immediate loading,sinus floor elevation,sinuslifting,titanium implantion,surface modification,RETAINED MANDIBULAR OVERDENTURES,TIOBLAST DENTAL IMPLANTS,SINUS FLOOR AUGMENTATION,HUMAN POSTERIOR MAXILLA,UP CLINICAL REPORT,FOLLOW-UP,HISTOMORPHOMETRIC EVALUATION,RADIOGRAPHIC EVALUATION,TITANIUM MICROIMPLANTS,EDENTULOUS PATIENTS},
  language     = {eng},
  number       = {1},
  pages        = {36--44},
  title        = {The histological evaluation of osseointegration of surface enhanced microimplants immediately loaded in conjunction with sinuslifting in humans},
  url          = {http://dx.doi.org/10.1111/j.1600-0501.2011.02398.x},
  volume       = {24},
  year         = {2013},
}

Chicago
BROWAEYS, HILDE, Stefan Vandeweghe, Carina B Johansson, Ryo Jimbo, Ellen Deschepper, and Hugo De Bruyn. 2013. “The Histological Evaluation of Osseointegration of Surface Enhanced Microimplants Immediately Loaded in Conjunction with Sinuslifting in Humans.” Clinical Oral Implants Research 24 (1): 36–44.
APA
BROWAEYS, H., Vandeweghe, S., Johansson, C. B., Jimbo, R., Deschepper, E., & De Bruyn, H. (2013). The histological evaluation of osseointegration of surface enhanced microimplants immediately loaded in conjunction with sinuslifting in humans. CLINICAL ORAL IMPLANTS RESEARCH, 24(1), 36–44.
Vancouver
1.
BROWAEYS H, Vandeweghe S, Johansson CB, Jimbo R, Deschepper E, De Bruyn H. The histological evaluation of osseointegration of surface enhanced microimplants immediately loaded in conjunction with sinuslifting in humans. CLINICAL ORAL IMPLANTS RESEARCH. 2013;24(1):36–44.
MLA
BROWAEYS, HILDE, Stefan Vandeweghe, Carina B Johansson, et al. “The Histological Evaluation of Osseointegration of Surface Enhanced Microimplants Immediately Loaded in Conjunction with Sinuslifting in Humans.” CLINICAL ORAL IMPLANTS RESEARCH 24.1 (2013): 36–44. Print.