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Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system

Khalil Abou-El-Ardat, Hanane Derradji, Winnok De Vos UGent, Tim De Meyer UGent, Sofie Bekaert UGent, Wim Van Criekinge UGent and Sarah Baatout UGent (2011) INTERNATIONAL JOURNAL OF ONCOLOGY. 39(6). p.1429-1441
abstract
The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investigated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-I cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
p73, p53, apoptosis, RET/PTC1, papillary thyroid carcinoma, radiation, IONIZING-RADIATION, CANCER CELLS, TUMOR-SUPPRESSOR, IN-VIVO, SENESCENCE, P53, RISK, FIBROBLASTS, MECHANISMS, APOPTOSIS
journal title
INTERNATIONAL JOURNAL OF ONCOLOGY
Int. J. Oncol.
volume
39
issue
6
pages
1429 - 1441
Web of Science type
Article
Web of Science id
000296315400011
JCR category
ONCOLOGY
JCR impact factor
2.399 (2011)
JCR rank
108/190 (2011)
JCR quartile
3 (2011)
ISSN
1019-6439
DOI
10.3892/ijo.2011.1175
project
Bioinformatics: from nucleotids to networks (N2N)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1968135
handle
http://hdl.handle.net/1854/LU-1968135
date created
2011-12-15 14:29:02
date last changed
2016-12-19 15:39:35
@article{1968135,
  abstract     = {The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investigated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-I cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21.},
  author       = {Abou-El-Ardat, Khalil and Derradji, Hanane and De Vos, Winnok and De Meyer, Tim and Bekaert, Sofie and Van Criekinge, Wim and Baatout, Sarah},
  issn         = {1019-6439},
  journal      = {INTERNATIONAL JOURNAL OF ONCOLOGY},
  keyword      = {p73,p53,apoptosis,RET/PTC1,papillary thyroid carcinoma,radiation,IONIZING-RADIATION,CANCER CELLS,TUMOR-SUPPRESSOR,IN-VIVO,SENESCENCE,P53,RISK,FIBROBLASTS,MECHANISMS,APOPTOSIS},
  language     = {eng},
  number       = {6},
  pages        = {1429--1441},
  title        = {Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system},
  url          = {http://dx.doi.org/10.3892/ijo.2011.1175},
  volume       = {39},
  year         = {2011},
}
Chicago
Abou-El-Ardat, Khalil, Hanane Derradji, Winnok De Vos, Tim De Meyer, Sofie Bekaert, Wim Van Criekinge, and Sarah Baatout. 2011. “Response to Low-dose X-irradiation Is P53-dependent in a Papillary Thyroid Carcinoma Model System.” International Journal of Oncology 39 (6): 1429–1441.
APA
Abou-El-Ardat, Khalil, Derradji, H., De Vos, W., De Meyer, T., Bekaert, S., Van Criekinge, W., & Baatout, S. (2011). Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. INTERNATIONAL JOURNAL OF ONCOLOGY, 39(6), 1429–1441.
Vancouver
1.
Abou-El-Ardat K, Derradji H, De Vos W, De Meyer T, Bekaert S, Van Criekinge W, et al. Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;39(6):1429–41.
MLA
Abou-El-Ardat, Khalil, Hanane Derradji, Winnok De Vos, et al. “Response to Low-dose X-irradiation Is P53-dependent in a Papillary Thyroid Carcinoma Model System.” INTERNATIONAL JOURNAL OF ONCOLOGY 39.6 (2011): 1429–1441. Print.