Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system
(2011) INTERNATIONAL JOURNAL OF ONCOLOGY. 39(6). p.1429-1441- abstract
- The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investigated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-I cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21.
Please use this url to cite or link to this publication:
http://hdl.handle.net/1854/LU-1968135
- author
- Khalil Abou-El-Ardat, Hanane Derradji, Winnok De Vos UGent, Tim De Meyer UGent, Sofie Bekaert UGent, Wim Van Criekinge UGent and Sarah Baatout UGent
- organization
- year
- 2011
- type
- journalArticle (original)
- publication status
- published
- subject
- keyword
- p73, p53, apoptosis, RET/PTC1, papillary thyroid carcinoma, radiation, IONIZING-RADIATION, CANCER CELLS, TUMOR-SUPPRESSOR, IN-VIVO, SENESCENCE, P53, RISK, FIBROBLASTS, MECHANISMS, APOPTOSIS
- journal title
- INTERNATIONAL JOURNAL OF ONCOLOGY
- Int. J. Oncol.
- volume
- 39
- issue
- 6
- pages
- 1429 - 1441
- Web of Science type
- Article
- Web of Science id
- 000296315400011
- JCR category
- ONCOLOGY
- JCR impact factor
- 2.399 (2011)
- JCR rank
- 108/190 (2011)
- JCR quartile
- 3 (2011)
- ISSN
- 1019-6439
- DOI
- 10.3892/ijo.2011.1175
- project
- Bioinformatics: from nucleotids to networks (N2N)
- language
- English
- UGent publication?
- yes
- classification
- A1
- copyright statement
- I have transferred the copyright for this publication to the publisher
- id
- 1968135
- handle
- http://hdl.handle.net/1854/LU-1968135
- date created
- 2011-12-15 14:29:02
- date last changed
- 2016-12-19 15:39:35
@article{1968135, abstract = {The link between high doses of radiation and thyroid cancer has been well established in various studies, as opposed to the effects of low doses. In this study, we investigated the effects of low-dose X-ray irradiation in a papillary thyroid carcinoma model with wild-type and mutated p53. A low dose of 62.5 mGy was enough to cause an upregulation of p16 and a decrease in the number of TPC-1 cells in the S phase, but not in the number of BCPAP p53-mutant cells. At a dose of 0.5 Gy, visible signs of senescence appeared only in the TPC-I cells. We conclude that low doses of X-rays are enough to cause a change in cell cycle distribution, possibly p53dependent p16 activation, but no significant apoptosis. Senescence requires higher doses of X-irradiation via a mechanism involving both p16 and p21.}, author = {Abou-El-Ardat, Khalil and Derradji, Hanane and De Vos, Winnok and De Meyer, Tim and Bekaert, Sofie and Van Criekinge, Wim and Baatout, Sarah}, issn = {1019-6439}, journal = {INTERNATIONAL JOURNAL OF ONCOLOGY}, keyword = {p73,p53,apoptosis,RET/PTC1,papillary thyroid carcinoma,radiation,IONIZING-RADIATION,CANCER CELLS,TUMOR-SUPPRESSOR,IN-VIVO,SENESCENCE,P53,RISK,FIBROBLASTS,MECHANISMS,APOPTOSIS}, language = {eng}, number = {6}, pages = {1429--1441}, title = {Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system}, url = {http://dx.doi.org/10.3892/ijo.2011.1175}, volume = {39}, year = {2011}, }
- Chicago
- Abou-El-Ardat, Khalil, Hanane Derradji, Winnok De Vos, Tim De Meyer, Sofie Bekaert, Wim Van Criekinge, and Sarah Baatout. 2011. “Response to Low-dose X-irradiation Is P53-dependent in a Papillary Thyroid Carcinoma Model System.” International Journal of Oncology 39 (6): 1429–1441.
- APA
- Abou-El-Ardat, Khalil, Derradji, H., De Vos, W., De Meyer, T., Bekaert, S., Van Criekinge, W., & Baatout, S. (2011). Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. INTERNATIONAL JOURNAL OF ONCOLOGY, 39(6), 1429–1441.
- Vancouver
- 1.Abou-El-Ardat K, Derradji H, De Vos W, De Meyer T, Bekaert S, Van Criekinge W, et al. Response to low-dose X-irradiation is p53-dependent in a papillary thyroid carcinoma model system. INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;39(6):1429–41.
- MLA
- Abou-El-Ardat, Khalil, Hanane Derradji, Winnok De Vos, et al. “Response to Low-dose X-irradiation Is P53-dependent in a Papillary Thyroid Carcinoma Model System.” INTERNATIONAL JOURNAL OF ONCOLOGY 39.6 (2011): 1429–1441. Print.