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Prebiotics to manage the microbial control of energy homeostasis

Charlotte Grootaert UGent, Massimo Marzorati UGent, Pieter Van den Abbeele UGent, Tom Van de Wiele UGent and Sam Possemiers UGent (2011) BENEFICIAL MICROBES. 2(4). p.305-318
abstract
The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial community associated to the human host in controlling and influencing the energy homeostasis. According to the concept of Gastrointestinal Resource Management, this microbiota and its metabolic potential can be steered with the aim of improving host health. This review therefore focuses on the modulation of the intestinal microbiota through prebiotics with the aim to control of several aspects of metabolic homeostasis. In a first part, the importance of host-microbe cross-talk at the intestinal epithelium is discussed. Yet, energy metabolism, which includes both lipid and glucose metabolism, is also regulated by several key organs including the adipose tissue, brain, liver, muscles, pancreas and gut. Therefore, in a second part, we will discuss the microbial factors that are involved in the communication between these different tissues, and their potential management. Finally, we will give some future prospects of the use of prebiotics in an individualized treatment of metabolic disorders.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
obesity, diabetes, homeostasis, Prebiotics, mucosa, GLUCAGON-LIKE PEPTIDE-1, DIET-INDUCED OBESITY, IMPROVES INSULIN SENSITIVITY, INNATE IMMUNE-SYSTEM, CHAIN FATTY-ACIDS, HIGH-FIBER DIET, GUT MICROBIOTA, LIPID-METABOLISM, INTESTINAL MICROBIOTA, RESISTANT STARCH
journal title
BENEFICIAL MICROBES
Beneficial Microbes
volume
2
issue
4
pages
305 - 318
Web of Science type
Article
Web of Science id
000306086900006
ISSN
1876-2883
DOI
10.3920/BM2011.0020
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1966070
handle
http://hdl.handle.net/1854/LU-1966070
date created
2011-12-13 14:04:29
date last changed
2012-11-05 15:18:09
@article{1966070,
  abstract     = {The prevalence of obesity is continuously growing and has reached epidemic proportions. It is clear that current methods to combat obesity are not effective enough to reduce the problem. Therefore, further investigation is needed to develop new strategies. Recent research pointed out a potential role of the microbial community associated to the human host in controlling and influencing the energy homeostasis. According to the concept of Gastrointestinal Resource Management, this microbiota and its metabolic potential can be steered with the aim of improving host health. This review therefore focuses on the modulation of the intestinal microbiota through prebiotics with the aim to control of several aspects of metabolic homeostasis. In a first part, the importance of host-microbe cross-talk at the intestinal epithelium is discussed. Yet, energy metabolism, which includes both lipid and glucose metabolism, is also regulated by several key organs including the adipose tissue, brain, liver, muscles, pancreas and gut. Therefore, in a second part, we will discuss the microbial factors that are involved in the communication between these different tissues, and their potential management. Finally, we will give some future prospects of the use of prebiotics in an individualized treatment of metabolic disorders.},
  author       = {Grootaert, Charlotte and Marzorati, Massimo and Van den Abbeele, Pieter and Van de Wiele, Tom and Possemiers, Sam},
  issn         = {1876-2883},
  journal      = {BENEFICIAL MICROBES},
  keyword      = {obesity,diabetes,homeostasis,Prebiotics,mucosa,GLUCAGON-LIKE PEPTIDE-1,DIET-INDUCED OBESITY,IMPROVES INSULIN SENSITIVITY,INNATE IMMUNE-SYSTEM,CHAIN FATTY-ACIDS,HIGH-FIBER DIET,GUT MICROBIOTA,LIPID-METABOLISM,INTESTINAL MICROBIOTA,RESISTANT STARCH},
  language     = {eng},
  number       = {4},
  pages        = {305--318},
  title        = {Prebiotics to manage the microbial control of energy homeostasis},
  url          = {http://dx.doi.org/10.3920/BM2011.0020},
  volume       = {2},
  year         = {2011},
}

Chicago
Grootaert, Charlotte, Massimo Marzorati, Pieter Van den Abbeele, Tom Van de Wiele, and Sam Possemiers. 2011. “Prebiotics to Manage the Microbial Control of Energy Homeostasis.” Beneficial Microbes 2 (4): 305–318.
APA
Grootaert, C., Marzorati, M., Van den Abbeele, P., Van de Wiele, T., & Possemiers, S. (2011). Prebiotics to manage the microbial control of energy homeostasis. BENEFICIAL MICROBES, 2(4), 305–318.
Vancouver
1.
Grootaert C, Marzorati M, Van den Abbeele P, Van de Wiele T, Possemiers S. Prebiotics to manage the microbial control of energy homeostasis. BENEFICIAL MICROBES. 2011;2(4):305–18.
MLA
Grootaert, Charlotte, Massimo Marzorati, Pieter Van den Abbeele, et al. “Prebiotics to Manage the Microbial Control of Energy Homeostasis.” BENEFICIAL MICROBES 2.4 (2011): 305–318. Print.