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The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis

(2011) CANCER CELL. 20(5). p.649-660
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Abstract
NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, chemokines, and tumorigenic factors. Enhanced colon inflammation and colorectal tumor development in Nlrp12-deficient mice are due to a failure to dampen NF-kappa B and ERK activation in macrophages. These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis.
Keywords
PROTEIN, SUSCEPTIBILITY, MICE, ACTIVATION, CUTTING EDGE, ULCERATIVE-COLITIS, BOWEL-DISEASE, COLORECTAL-CANCER, NF-KAPPA-B, CROHNS-DISEASE

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Citation

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Chicago
Zaki, Md Hasan, Peter Vogel, RK Subbarao Malireddi, Mathilde Body-Malapel, Paras K Anand, John Bertin, Douglas R Green, Mohamed Lamkanfi, and Thirumala-Devi Kanneganti. 2011. “The NOD-like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis.” Cancer Cell 20 (5): 649–660.
APA
Zaki, Md Hasan, Vogel, P., Malireddi, R. S., Body-Malapel, M., Anand, P. K., Bertin, J., Green, D. R., et al. (2011). The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. CANCER CELL, 20(5), 649–660.
Vancouver
1.
Zaki MH, Vogel P, Malireddi RS, Body-Malapel M, Anand PK, Bertin J, et al. The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis. CANCER CELL. 2011;20(5):649–60.
MLA
Zaki, Md Hasan, Peter Vogel, RK Subbarao Malireddi, et al. “The NOD-like Receptor NLRP12 Attenuates Colon Inflammation and Tumorigenesis.” CANCER CELL 20.5 (2011): 649–660. Print.
@article{1964187,
  abstract     = {NLRP12 is a member of the intracellular Nod-like receptor (NLR) family that has been suggested to downregulate the production of inflammatory cytokines, but its physiological role in regulating inflammation has not been characterized. We analyzed mice deficient in Nlrp12 to study its role in inflammatory diseases such as colitis and colorectal tumorigenesis. We show that Nlrp12-deficient mice are highly susceptible to colon inflammation and tumorigenesis, which is associated with increased production of inflammatory cytokines, chemokines, and tumorigenic factors. Enhanced colon inflammation and colorectal tumor development in Nlrp12-deficient mice are due to a failure to dampen NF-kappa B and ERK activation in macrophages. These results reveal a critical role for NLRP12 in maintaining intestinal homeostasis and providing protection against colorectal tumorigenesis.},
  author       = {Zaki, Md Hasan and Vogel, Peter and Malireddi, RK Subbarao and Body-Malapel, Mathilde and Anand, Paras K and Bertin, John and Green, Douglas R and Lamkanfi, Mohamed and Kanneganti, Thirumala-Devi},
  issn         = {1535-6108},
  journal      = {CANCER CELL},
  language     = {eng},
  number       = {5},
  pages        = {649--660},
  title        = {The NOD-like receptor NLRP12 attenuates colon inflammation and tumorigenesis},
  url          = {http://dx.doi.org/10.1016/j.ccr.2011.10.022},
  volume       = {20},
  year         = {2011},
}

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