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Alteration in N-glycomics during mouse aging: a role for FUT8

Valerie Vanhooren UGent, Sylviane Dewaele UGent, Makoto Kuro-o, Naoyuki Taniguchi, Laurent Dollé, Leo A van Grunsven, Evgenia Makrantonaki, Christos C Zouboulis, Cuiying Chen UGent and Claude Libert UGent (2011) AGING CELL. 10(6). p.1056-1066
abstract
We recently reported that N-glycosylation changes during human aging. To further investigate the molecular basis determining these alterations, the aging process in mice was studied. N-glycan profiling of mouse serum glycoproteins in different age groups of healthy C57BL/6 mice showed substantial age-related changes in three major N-glycan structures: under-galactosylated biantennary (NGA2F), biantennary (NA2), and core alpha-1,6-fucosylated-beta-galactosylated biantennary structures (NA2F). Mice defective in klotho gene expression (kl/kl), which have a shortened lifespan, displayed a similar but accelerated trend. Interestingly, the opposite trend was observed in slow-aging Snell Dwarf mice (dw/dw) and in mice fed a calorically restricted diet. We also discovered that increased expression and activity of alpha-1,6-fucosyltransferase (FUT8) in the liver are strongly linked to the age-related changes in glycosylation and that this increased FUT8 and fucosylation influence IGF-1 signaling. These data demonstrate that the glycosylation machinery in liver cells is significantly affected during aging and that age-related increased FUT8 activity could influence the aging process by altering the sensitivity of the IGF-1R signaling pathway.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
klotho mouse, caloric restriction, Snell Dwarf, aging, glycosylation, N-glycan, CALORIE RESTRICTION, CORE FUCOSYLATION, MUTANT MICE, SNELL DWARF, LIFE-SPAN, IN-VITRO, GROWTH, AGE, GLYCOSYLATION, RECEPTOR
journal title
AGING CELL
Aging Cell
volume
10
issue
6
pages
1056 - 1066
Web of Science type
Article
Web of Science id
000297003800015
JCR category
GERIATRICS & GERONTOLOGY
JCR impact factor
6.265 (2011)
JCR rank
1/44 (2011)
JCR quartile
1 (2011)
ISSN
1474-9718
DOI
10.1111/j.1474-9726.2011.00749.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1963709
handle
http://hdl.handle.net/1854/LU-1963709
date created
2011-12-08 14:53:24
date last changed
2012-06-26 14:32:29
@article{1963709,
  abstract     = {We recently reported that N-glycosylation changes during human aging. To further investigate the molecular basis determining these alterations, the aging process in mice was studied. N-glycan profiling of mouse serum glycoproteins in different age groups of healthy C57BL/6 mice showed substantial age-related changes in three major N-glycan structures: under-galactosylated biantennary (NGA2F), biantennary (NA2), and core alpha-1,6-fucosylated-beta-galactosylated biantennary structures (NA2F). Mice defective in klotho gene expression (kl/kl), which have a shortened lifespan, displayed a similar but accelerated trend. Interestingly, the opposite trend was observed in slow-aging Snell Dwarf mice (dw/dw) and in mice fed a calorically restricted diet. We also discovered that increased expression and activity of alpha-1,6-fucosyltransferase (FUT8) in the liver are strongly linked to the age-related changes in glycosylation and that this increased FUT8 and fucosylation influence IGF-1 signaling. These data demonstrate that the glycosylation machinery in liver cells is significantly affected during aging and that age-related increased FUT8 activity could influence the aging process by altering the sensitivity of the IGF-1R signaling pathway.},
  author       = {Vanhooren, Valerie and Dewaele, Sylviane and Kuro-o, Makoto and Taniguchi, Naoyuki and Doll{\'e}, Laurent and van Grunsven, Leo A and Makrantonaki, Evgenia and Zouboulis, Christos C and Chen, Cuiying and Libert, Claude},
  issn         = {1474-9718},
  journal      = {AGING CELL},
  keyword      = {klotho mouse,caloric restriction,Snell Dwarf,aging,glycosylation,N-glycan,CALORIE RESTRICTION,CORE FUCOSYLATION,MUTANT MICE,SNELL DWARF,LIFE-SPAN,IN-VITRO,GROWTH,AGE,GLYCOSYLATION,RECEPTOR},
  language     = {eng},
  number       = {6},
  pages        = {1056--1066},
  title        = {Alteration in N-glycomics during mouse aging: a role for FUT8},
  url          = {http://dx.doi.org/10.1111/j.1474-9726.2011.00749.x},
  volume       = {10},
  year         = {2011},
}

Chicago
Vanhooren, Valerie, Sylviane Dewaele, Makoto Kuro-o, Naoyuki Taniguchi, Laurent Dollé, Leo A van Grunsven, Evgenia Makrantonaki, Christos C Zouboulis, Cuiying Chen, and Claude Libert. 2011. “Alteration in N-glycomics During Mouse Aging: a Role for FUT8.” Aging Cell 10 (6): 1056–1066.
APA
Vanhooren, V., Dewaele, S., Kuro-o, M., Taniguchi, N., Dollé, L., van Grunsven, L. A., Makrantonaki, E., et al. (2011). Alteration in N-glycomics during mouse aging: a role for FUT8. AGING CELL, 10(6), 1056–1066.
Vancouver
1.
Vanhooren V, Dewaele S, Kuro-o M, Taniguchi N, Dollé L, van Grunsven LA, et al. Alteration in N-glycomics during mouse aging: a role for FUT8. AGING CELL. 2011;10(6):1056–66.
MLA
Vanhooren, Valerie, Sylviane Dewaele, Makoto Kuro-o, et al. “Alteration in N-glycomics During Mouse Aging: a Role for FUT8.” AGING CELL 10.6 (2011): 1056–1066. Print.