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Exploring electrospun fibers for pharmaceutical use

Chaobo Huang UGent (2011)
abstract
Electrospun nanofibers and webs offer advantages for a wide range of applications in a variety of fields, including biomedicine, chemical sensing and biotechnology. In this thesis the following applications of electrospun fibers were explored: a): digitally encoded fibers to be used as anti-counterfeiting tool in medicines, b): inhibition of human immunodeficiency virus (HIV) infection though an adsorption filter made from electrospun fiber webs, c): inhibition of HIV infection though pH-sensitive cellulose acetate phthalate (CAP) fiber webs, loaded with antiviral agents (TMC125 or Viread), d): magnetic fiber webs for cancer treatment. In Chapter 1 we overviewed diverse stimuli responsive electrospun fibers and their applications. In Chapter 2 we proposed to label oral medicines, in particular tablet formulations, by using memofibers. This simple, inexpensive strategy makes the memofiber concept even more attractive for use in developing countries, especially where patients suffer or die from counterfeited medicines of inferior quality. In Chapter 3, the use of electrospun fibers for antiviral applications was looked into. The results point to the enormous potential these fibers have for intravaginal application as thin films as a possible means to counter HIV-1 spreading. In Chapter 4 we further focused on the use of electrospun fibers as tools to combat HIV infection. CAP fibers loaded with anti-HIV drugs (TMC 125 and Viread) were found to inhibit HIV-1 infection when released from the fibers by human semen, supporting the potential of CAP fibers in preventing HIV-1 spread during sexual intercourse. In Chapter 5 we described the incorporation of iron oxide nanoparticles (IONP) into electrospun PS fibers for the purpose of developing novel mediators for magnetic hyperthermia as an anti-cancer strategy. Complete cell death was already observed after exposing the fibers for 10 min to the magnetic field.
Please use this url to cite or link to this publication:
author
promoter
UGent and UGent
organization
year
type
dissertation (monograph)
subject
pages
163 pages
publisher
Ghent University. Faculty of Pharmaceutical Sciences
place of publication
Ghent, Belgium
defense location
Gent : Farmaceutisch Instituut (auditorium I)
defense date
2011-12-02 18:00
language
English
UGent publication?
yes
classification
D1
additional info
dissertation consists of copyrighted material
copyright statement
I have transferred the copyright for this publication to the publisher
id
1960606
handle
http://hdl.handle.net/1854/LU-1960606
date created
2011-12-06 11:21:41
date last changed
2011-12-06 11:46:41
@phdthesis{1960606,
  abstract     = {Electrospun nanofibers and webs offer advantages for a wide range of applications in a variety of fields, including biomedicine, chemical sensing and biotechnology. In this thesis the following applications of electrospun fibers were explored: a): digitally encoded fibers to be used as anti-counterfeiting tool in medicines, b): inhibition of human immunodeficiency virus (HIV) infection though an adsorption filter made from electrospun fiber webs, c): inhibition of HIV infection though pH-sensitive cellulose acetate phthalate (CAP) fiber webs, loaded with antiviral agents (TMC125 or Viread), d): magnetic fiber webs for cancer treatment. In Chapter 1 we overviewed diverse stimuli responsive electrospun fibers and their applications. In Chapter 2 we proposed to label oral medicines, in particular tablet formulations, by using memofibers. This simple, inexpensive strategy makes the memofiber concept even more attractive for use in developing countries, especially where patients suffer or die from counterfeited medicines of inferior quality. In Chapter 3, the use of electrospun fibers for antiviral applications was looked into. The results point to the enormous potential these fibers have for intravaginal application as thin films as a possible means to counter HIV-1 spreading. In Chapter 4 we further focused on the use of electrospun fibers as tools to combat HIV infection. CAP fibers loaded with anti-HIV drugs (TMC 125 and Viread) were found to inhibit HIV-1 infection when released from the fibers by human semen, supporting the potential of CAP fibers in preventing HIV-1 spread during sexual intercourse. In Chapter 5 we described the incorporation of iron oxide nanoparticles (IONP) into electrospun PS fibers for the purpose of developing novel mediators for magnetic hyperthermia as an anti-cancer strategy. Complete cell death was already observed after exposing the fibers for 10 min to the magnetic field.},
  author       = {Huang, Chaobo},
  language     = {eng},
  pages        = {163},
  publisher    = {Ghent University. Faculty of Pharmaceutical Sciences},
  school       = {Ghent University},
  title        = {Exploring electrospun fibers for pharmaceutical use},
  year         = {2011},
}

Chicago
Huang, Chaobo. 2011. “Exploring Electrospun Fibers for Pharmaceutical Use”. Ghent, Belgium: Ghent University. Faculty of Pharmaceutical Sciences.
APA
Huang, Chaobo. (2011). Exploring electrospun fibers for pharmaceutical use. Ghent University. Faculty of Pharmaceutical Sciences, Ghent, Belgium.
Vancouver
1.
Huang C. Exploring electrospun fibers for pharmaceutical use. [Ghent, Belgium]: Ghent University. Faculty of Pharmaceutical Sciences; 2011.
MLA
Huang, Chaobo. “Exploring Electrospun Fibers for Pharmaceutical Use.” 2011 : n. pag. Print.