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Enterocyte death and intestinal barrier maintenance in homeostasis and disease

Lars Vereecke (UGent) , Rudi Beyaert (UGent) and Geert van Loo (UGent)
(2011) TRENDS IN MOLECULAR MEDICINE. 17(10). p.584-593
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
The intestinal epithelium is the largest surface area of the body in contact with the external environment. This specialized single cell layer is constantly renewed and is a physical barrier that separates intestinal microbiota from underlying tissues, preventing bacterial infiltration and subsequent inflammation. Specialized secretory epithelial cell types such as Paneth cells and goblet cells limit bacterial adhesion and infiltration by secreting antibacterial peptides and mucins, respectively. Rapid cell renewal coincides with apical exfoliation of 'old' enterocytes without compromising epithelial barrier integrity. When the intestinal epithelium is inflamed barrier integrity can be compromised, due to uncontrolled death of enterocytes allowing bacterial infiltration. This review discusses the different mechanisms which regulate or affect intestinal barrier integrity under homeostatic and inflammatory conditions.
Keywords
ENDOPLASMIC-RETICULUM STRESS, TUMOR-NECROSIS-FACTOR, NF-KAPPA-B, INFLAMMATORY-BOWEL-DISEASE, GENOME-WIDE ASSOCIATION, BINDING DOMAIN PEPTIDE, TOLL-LIKE RECEPTORS, CROHNS-DISEASE, PANETH CELLS, EXPERIMENTAL COLITIS

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Citation

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Chicago
Vereecke, Lars, Rudi Beyaert, and Geert van Loo. 2011. “Enterocyte Death and Intestinal Barrier Maintenance in Homeostasis and Disease.” Trends in Molecular Medicine 17 (10): 584–593.
APA
Vereecke, L., Beyaert, R., & van Loo, G. (2011). Enterocyte death and intestinal barrier maintenance in homeostasis and disease. TRENDS IN MOLECULAR MEDICINE, 17(10), 584–593.
Vancouver
1.
Vereecke L, Beyaert R, van Loo G. Enterocyte death and intestinal barrier maintenance in homeostasis and disease. TRENDS IN MOLECULAR MEDICINE. 2011;17(10):584–93.
MLA
Vereecke, Lars, Rudi Beyaert, and Geert van Loo. “Enterocyte Death and Intestinal Barrier Maintenance in Homeostasis and Disease.” TRENDS IN MOLECULAR MEDICINE 17.10 (2011): 584–593. Print.
@article{1960369,
  abstract     = {The intestinal epithelium is the largest surface area of the body in contact with the external environment. This specialized single cell layer is constantly renewed and is a physical barrier that separates intestinal microbiota from underlying tissues, preventing bacterial infiltration and subsequent inflammation. Specialized secretory epithelial cell types such as Paneth cells and goblet cells limit bacterial adhesion and infiltration by secreting antibacterial peptides and mucins, respectively. Rapid cell renewal coincides with apical exfoliation of 'old' enterocytes without compromising epithelial barrier integrity. When the intestinal epithelium is inflamed barrier integrity can be compromised, due to uncontrolled death of enterocytes allowing bacterial infiltration. This review discusses the different mechanisms which regulate or affect intestinal barrier integrity under homeostatic and inflammatory conditions.},
  author       = {Vereecke, Lars and Beyaert, Rudi and van Loo, Geert},
  issn         = {1471-4914},
  journal      = {TRENDS IN MOLECULAR MEDICINE},
  language     = {eng},
  number       = {10},
  pages        = {584--593},
  title        = {Enterocyte death and intestinal barrier maintenance in homeostasis and disease},
  url          = {http://dx.doi.org/10.1016/j.molmed.2011.05.011},
  volume       = {17},
  year         = {2011},
}

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