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Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients

Reinhart Speeckaert UGent, Bob Colebunders, Johan R Boelaert, Lieve Brochez UGent, Jos Van Acker, FILIP VAN WANZEELE UGent, Robert Hemmer, MARIJN SPEECKAERT UGent, Chris Verhofstede UGent and Marc De Buyzere UGent, et al. (2011) ARCHIVES OF DERMATOLOGICAL RESEARCH. 303(10). p.763-769
abstract
Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p < 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p < 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Haptoglobin, HIV, Genetic polymorphism, Kaposi's sarcoma, RENAL-TRANSPLANT RECIPIENTS, BODY IRON STORES, LANGERHANS CELLS, DENDRITIC CELLS, POLYMORPHISM, CANCER, RISK, HERPESVIRUS, INFECTION, INTERLEUKIN-6
journal title
ARCHIVES OF DERMATOLOGICAL RESEARCH
Arch. Dermatol. Res.
volume
303
issue
10
pages
763 - 769
Web of Science type
Article
Web of Science id
000297374000008
JCR category
DERMATOLOGY
JCR impact factor
2.279 (2011)
JCR rank
17/58 (2011)
JCR quartile
2 (2011)
ISSN
0340-3696
DOI
10.1007/s00403-011-1161-9
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1956518
handle
http://hdl.handle.net/1854/LU-1956518
date created
2011-11-30 10:45:30
date last changed
2012-05-08 10:48:55
@article{1956518,
  abstract     = {Kaposi's sarcoma (KS) is a rare cutaneous tumor caused by human herpes virus-8 (HHV-8) infection that preferentially develops in case of severe immunosuppression, such as in HIV/AIDS disease. Haptoglobin (Hp), a polymorphic multifunctional plasma protein, exerts several immunomodulatory effects and is characterized by a genetic polymorphism leading to three major phenotypes (Hp 1-1, Hp 2-1 and Hp 2-2). This study investigated the influence of Hp genetic polymorphism on the development of KS in HIV-positive patients. 661 HIV patients were enrolled in the study with a median age of 35 years and a median follow-up time of 57 months. Hp phenotyping was performed using hemoglobin-supplemented starch gel electrophoresis. In case of low Hp concentration high pressure gel permeation chromatography (HPGPC) was used. The Hp 1-1 phenotype was associated with a significant higher risk of KS compared to the combined group of Hp 2-1 and Hp 2-2 patients (p {\textlangle} 0.0005) which remained significant after adjustment for possible confounding variables (age, gender and AIDS status) (p {\textlangle} 0.001). In contrast, the Hp 2-1 phenotype carried the lowest risk. These findings point to the involvement of Hp phenotypes in the pathogenesis of KS, which may be due to a difference in skin immunosurveillance between the Hp phenotypes},
  author       = {Speeckaert, Reinhart and Colebunders, Bob and Boelaert, Johan R and Brochez, Lieve and Van Acker, Jos and VAN WANZEELE, FILIP and Hemmer, Robert and SPEECKAERT, MARIJN and Verhofstede, Chris and De Buyzere, Marc and Arendt, Vic and Plum, Jean and Delanghe, Joris},
  issn         = {0340-3696},
  journal      = {ARCHIVES OF DERMATOLOGICAL RESEARCH},
  keyword      = {Haptoglobin,HIV,Genetic polymorphism,Kaposi's sarcoma,RENAL-TRANSPLANT RECIPIENTS,BODY IRON STORES,LANGERHANS CELLS,DENDRITIC CELLS,POLYMORPHISM,CANCER,RISK,HERPESVIRUS,INFECTION,INTERLEUKIN-6},
  language     = {eng},
  number       = {10},
  pages        = {763--769},
  title        = {Association of haptoglobin phenotypes with the development of Kaposi's sarcoma in HIV patients},
  url          = {http://dx.doi.org/10.1007/s00403-011-1161-9},
  volume       = {303},
  year         = {2011},
}

Chicago
Speeckaert, Reinhart, Bob Colebunders, Johan R Boelaert, Lieve Brochez, Jos Van Acker, FILIP VAN WANZEELE, Robert Hemmer, et al. 2011. “Association of Haptoglobin Phenotypes with the Development of Kaposi’s Sarcoma in HIV Patients.” Archives of Dermatological Research 303 (10): 763–769.
APA
Speeckaert, R., Colebunders, B., Boelaert, J. R., Brochez, L., Van Acker, J., VAN WANZEELE, F., Hemmer, R., et al. (2011). Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients. ARCHIVES OF DERMATOLOGICAL RESEARCH, 303(10), 763–769.
Vancouver
1.
Speeckaert R, Colebunders B, Boelaert JR, Brochez L, Van Acker J, VAN WANZEELE F, et al. Association of haptoglobin phenotypes with the development of Kaposi’s sarcoma in HIV patients. ARCHIVES OF DERMATOLOGICAL RESEARCH. 2011;303(10):763–9.
MLA
Speeckaert, Reinhart, Bob Colebunders, Johan R Boelaert, et al. “Association of Haptoglobin Phenotypes with the Development of Kaposi’s Sarcoma in HIV Patients.” ARCHIVES OF DERMATOLOGICAL RESEARCH 303.10 (2011): 763–769. Print.