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Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations

Mireille Van Gele UGent, Barbara Geusens UGent, Lieve Brochez UGent, Reinhart Speeckaert UGent and Jo Lambert UGent (2011) EXPERT OPINION ON DRUG DELIVERY. 8(6). p.705-720
abstract
ntroduction: Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used on humans. In this regard, in vitro permeation methods are highly important to predict in vivo permeation of drugs. Areas covered: This review illustrates how different types of reconstructed skin models are being used as alternatives to human and pig skin for in vitro permeation testing of drugs. Insights into how various factors (including the physicochemical nature of molecules and formulations) or skin properties might affect the permeability of drugs in reconstructed skin models are provided. Also, opportunities and pitfalls of reconstructed skin models are highlighted. Expert opinion: Many studies have revealed that the permeability of reconstructed skin models is much higher compared with human excised skin. This is in accordance with the incomplete barrier found in these models. Nevertheless, the reconstructed skin models available today are useful tools for estimating the rank order of percutaneous absorption of a series of compounds with different physicochemical properties. A major challenge in the further development of reconstructed skin models for drug delivery studies is to obtain a barrier function similar to in vivo skin. Whether this goal will be achieved in the near future is uncertain and will be, in the authors' opinion, a very difficult task.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
skin permeability, reconstructed human skin model, stratum corneum, transdermal drug delivery, RECONSTRUCTED HUMAN EPIDERMIS, CUTANEOUS PERMEABILITY BARRIER, VITRO PERCUTANEOUS-ABSORPTION, X-RAY-DIFFRACTION, IN-VITRO, STRATUM-CORNEUM, ESTRADIOL PERMEATION, EX-VIVO, SUPERSATURATED SOLUTIONS, SILICONE MEMBRANES, partition coefficient
journal title
EXPERT OPINION ON DRUG DELIVERY
Expert Opin. Drug Deliv.
volume
8
issue
6
pages
705 - 720
Web of Science type
Review
Web of Science id
000290728900001
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
4.896 (2011)
JCR rank
21/259 (2011)
JCR quartile
1 (2011)
ISSN
1742-5247
DOI
10.1517/17425247.2011.568937
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1956205
handle
http://hdl.handle.net/1854/LU-1956205
date created
2011-11-29 16:02:43
date last changed
2011-11-30 12:03:20
@article{1956205,
  abstract     = {ntroduction: Transdermal drug delivery has several known advantages over the oral route and hypodermic injections. The number of drugs that can be taken up transdermally is, however, limited owing to the innate barrier function of the skin. New transdermal drug candidates need to be tested extensively before being used on humans. In this regard, in vitro permeation methods are highly important to predict in vivo permeation of drugs.
Areas covered: This review illustrates how different types of reconstructed skin models are being used as alternatives to human and pig skin for in vitro permeation testing of drugs. Insights into how various factors (including the physicochemical nature of molecules and formulations) or skin properties might affect the permeability of drugs in reconstructed skin models are provided. Also, opportunities and pitfalls of reconstructed skin models are highlighted.
Expert opinion: Many studies have revealed that the permeability of reconstructed skin models is much higher compared with human excised skin. This is in accordance with the incomplete barrier found in these models. Nevertheless, the reconstructed skin models available today are useful tools for estimating the rank order of percutaneous absorption of a series of compounds with different physicochemical properties. A major challenge in the further development of reconstructed skin models for drug delivery studies is to obtain a barrier function similar to in vivo skin. Whether this goal will be achieved in the near future is uncertain and will be, in the authors' opinion, a very difficult task.},
  author       = {Van Gele, Mireille and Geusens, Barbara and Brochez, Lieve and Speeckaert, Reinhart and Lambert, Jo},
  issn         = {1742-5247},
  journal      = {EXPERT OPINION ON DRUG DELIVERY},
  keyword      = {skin permeability,reconstructed human skin model,stratum corneum,transdermal drug delivery,RECONSTRUCTED HUMAN EPIDERMIS,CUTANEOUS PERMEABILITY BARRIER,VITRO PERCUTANEOUS-ABSORPTION,X-RAY-DIFFRACTION,IN-VITRO,STRATUM-CORNEUM,ESTRADIOL PERMEATION,EX-VIVO,SUPERSATURATED SOLUTIONS,SILICONE MEMBRANES,partition coefficient},
  language     = {eng},
  number       = {6},
  pages        = {705--720},
  title        = {Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations},
  url          = {http://dx.doi.org/10.1517/17425247.2011.568937},
  volume       = {8},
  year         = {2011},
}

Chicago
Van Gele, Mireille, Barbara Geusens, Lieve Brochez, Reinhart Speeckaert, and Jo Lambert. 2011. “Three-dimensional Skin Models as Tools for Transdermal Drug Delivery: Challenges and Limitations.” Expert Opinion on Drug Delivery 8 (6): 705–720.
APA
Van Gele, M., Geusens, B., Brochez, L., Speeckaert, R., & Lambert, J. (2011). Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations. EXPERT OPINION ON DRUG DELIVERY, 8(6), 705–720.
Vancouver
1.
Van Gele M, Geusens B, Brochez L, Speeckaert R, Lambert J. Three-dimensional skin models as tools for transdermal drug delivery: challenges and limitations. EXPERT OPINION ON DRUG DELIVERY. 2011;8(6):705–20.
MLA
Van Gele, Mireille, Barbara Geusens, Lieve Brochez, et al. “Three-dimensional Skin Models as Tools for Transdermal Drug Delivery: Challenges and Limitations.” EXPERT OPINION ON DRUG DELIVERY 8.6 (2011): 705–720. Print.