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Studies directed towards the total synthesis of (±)-himbacine

(1995) TETRAHEDRON LETTERS. 36(41). p.7515-7518
Author
Organization
Abstract
The synthesis of aldehyde 11a is reported based upon the intramolecular Diels-Alder reaction of triene 10, the butenolide-diene part of which was obtained in one step via the condensation of the enolate derived from the (Z)-enoate ester 5 with 2-acetoxypropanal. Aldehyde 11a possesses the correct stereochemistry of the tricyclic part of himbacine, an important muscarine receptor antagonist.
Keywords
DIELS-ALDER REACTION, MUSCARINIC RECEPTORS, HIMBACINE, BINDING

Citation

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Chicago
De Baecke, Govert, and Pierre De Clercq. 1995. “Studies Directed Towards the Total Synthesis of (±)-himbacine.” Tetrahedron Letters 36 (41): 7515–7518.
APA
De Baecke, G., & De Clercq, P. (1995). Studies directed towards the total synthesis of (±)-himbacine. TETRAHEDRON LETTERS, 36(41), 7515–7518.
Vancouver
1.
De Baecke G, De Clercq P. Studies directed towards the total synthesis of (±)-himbacine. TETRAHEDRON LETTERS. 1995;36(41):7515–8.
MLA
De Baecke, Govert, and Pierre De Clercq. “Studies Directed Towards the Total Synthesis of (±)-himbacine.” TETRAHEDRON LETTERS 36.41 (1995): 7515–7518. Print.
@article{195613,
  abstract     = {The synthesis of aldehyde 11a is reported based upon the intramolecular Diels-Alder reaction of triene 10, the butenolide-diene part of which was obtained in one step via the condensation of the enolate derived from the (Z)-enoate ester 5 with 2-acetoxypropanal. Aldehyde 11a possesses the correct stereochemistry of the tricyclic part of himbacine, an important muscarine receptor antagonist.},
  author       = {De Baecke, Govert and De Clercq, Pierre},
  issn         = {0040-4039},
  journal      = {TETRAHEDRON LETTERS},
  keyword      = {DIELS-ALDER REACTION,MUSCARINIC RECEPTORS,HIMBACINE,BINDING},
  language     = {eng},
  number       = {41},
  pages        = {7515--7518},
  title        = {Studies directed towards the total synthesis of ({\textpm})-himbacine},
  url          = {http://dx.doi.org/10.1016/0040-4039(95)01520-5},
  volume       = {36},
  year         = {1995},
}

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