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Necrosis: molecular mechanisms and physiological roles

Linde Duprez UGent, Nele Vanlangenakker UGent, Nele Festjens UGent, Franky Van Herreweghe UGent, Tom Vanden Berghe UGent and Peter Vandenabeele UGent (2009) Essentials of apoptosis : a guide for basic and clinical research. p.599-633
abstract
For a long time, necrosis has been considered an accidental and uncontrolled form of cell death, lacking underlying signaling events. However, accumulating evidence supports the existence of a caspase-independent cell death pathway that is also regulated and controlled. This regulated form of necrosis seems to be of relevance in both physiological and pathological conditions. For example, necrosis occurs during excitotoxicity, ischemia-reperfusion injury, neurodegenerative diseases, and infections. Research over the past decade indicates that necrosis results from an extensive interplay between several signaling events and a wide range of mediators. However, it is still not clear whether these many mediators represent various subroutines in different cell lines and what the precise relationship is between the signaling events and the activation of the mediators. The serine/threonine kinase receptor-interacting protein 1 (RIP1) apparently is a central initiator of necrotic cell death. Reactive oxygen species (ROS) and calcium are important mediators of necrosis, but several other mediators have also been described, such as phospholipases, calpains, cathepsins, ceramide, and methylglyoxal, all of which contribute to the disruption of organelles and the plasma membrane. Necrotically dying cells initiate a proinflammatory response by actively releasing immunomodulatory factors and passively releasing their contents when they lyse. Knowledge of the molecular mechanisms involved in necrosis has contributed to the development of therapeutic strategies for the treatment of pathologies associated with necrosis. This chapter focuses on the molecular events during regulated necrotic cell death and the link with several necrosisassociated pathologies.
Please use this url to cite or link to this publication:
author
organization
year
type
bookChapter
publication status
published
subject
book title
Essentials of apoptosis : a guide for basic and clinical research
editor
Xiao-Ming Yin and Zheng Dong
edition
2nd ed.
pages
599 - 633
publisher
Humana Press
place of publication
New York, NY, USA
ISBN
9781603273800
9781603273817
DOI
10.1007/978-1-60327-381-7_27
language
English
UGent publication?
yes
classification
B2
copyright statement
I have transferred the copyright for this publication to the publisher
id
1955420
handle
http://hdl.handle.net/1854/LU-1955420
date created
2011-11-29 10:33:09
date last changed
2012-06-26 14:31:56
@incollection{1955420,
  abstract     = {For a long time, necrosis has been considered an accidental and uncontrolled form of cell death, lacking underlying signaling events. However, accumulating evidence supports the existence of a caspase-independent cell death pathway that is also regulated and controlled. This regulated form of necrosis seems to be of relevance in both physiological and pathological conditions. For example, necrosis occurs during excitotoxicity, ischemia-reperfusion injury, neurodegenerative diseases, and infections. Research over the past decade indicates that necrosis results from an extensive interplay between several signaling events and a wide range of mediators. However, it is still not clear whether these many mediators represent various subroutines in different cell lines and what the precise relationship is between the signaling events and the activation of the mediators. The serine/threonine kinase receptor-interacting protein 1 (RIP1) apparently is a central initiator of necrotic cell death. Reactive oxygen species (ROS) and calcium are important mediators of necrosis, but several other mediators have also been described, such as phospholipases, calpains, cathepsins, ceramide, and methylglyoxal, all of which contribute to the disruption of organelles and the plasma membrane. Necrotically dying cells initiate a proinflammatory response by actively releasing immunomodulatory factors and passively releasing their contents when they lyse. Knowledge of the molecular mechanisms involved in necrosis has contributed to the development of therapeutic strategies for the treatment of pathologies associated with necrosis. This chapter focuses on the molecular events during regulated necrotic cell death and the link with several necrosisassociated pathologies.},
  author       = {Duprez, Linde and Vanlangenakker, Nele and Festjens, Nele and Van Herreweghe, Franky and Vanden Berghe, Tom and Vandenabeele, Peter},
  booktitle    = {Essentials of apoptosis : a guide for basic and clinical research},
  editor       = {Yin, Xiao-Ming and Dong, Zheng},
  isbn         = {9781603273800},
  language     = {eng},
  pages        = {599--633},
  publisher    = {Humana Press},
  title        = {Necrosis: molecular mechanisms and physiological roles},
  url          = {http://dx.doi.org/10.1007/978-1-60327-381-7\_27},
  year         = {2009},
}

Chicago
Duprez, Linde, Nele Vanlangenakker, Nele Festjens, Franky Van Herreweghe, Tom Vanden Berghe, and Peter Vandenabeele. 2009. “Necrosis: Molecular Mechanisms and Physiological Roles.” In Essentials of Apoptosis : a Guide for Basic and Clinical Research, ed. Xiao-Ming Yin and Zheng Dong, 599–633. 2nd ed. New York, NY, USA: Humana Press.
APA
Duprez, Linde, Vanlangenakker, N., Festjens, N., Van Herreweghe, F., Vanden Berghe, T., & Vandenabeele, P. (2009). Necrosis: molecular mechanisms and physiological roles. In X.-M. Yin & Z. Dong (Eds.), Essentials of apoptosis : a guide for basic and clinical research (2nd ed., pp. 599–633). New York, NY, USA: Humana Press.
Vancouver
1.
Duprez L, Vanlangenakker N, Festjens N, Van Herreweghe F, Vanden Berghe T, Vandenabeele P. Necrosis: molecular mechanisms and physiological roles. In: Yin X-M, Dong Z, editors. Essentials of apoptosis : a guide for basic and clinical research. 2nd ed. New York, NY, USA: Humana Press; 2009. p. 599–633.
MLA
Duprez, Linde, Nele Vanlangenakker, Nele Festjens, et al. “Necrosis: Molecular Mechanisms and Physiological Roles.” Essentials of Apoptosis : a Guide for Basic and Clinical Research. 2nd ed. Ed. Xiao-Ming Yin & Zheng Dong. New York, NY, USA: Humana Press, 2009. 599–633. Print.