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Caspase deficiency alters the murine gut microbiome

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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.
Keywords
MICE, IL-1-BETA-CONVERTING ENZYME, DEFENSE, HEALTH, CHAIN FATTY-ACIDS, gut microbiome, caspase-3, pyrosequencing, caspase-7, caspase-1, knockout

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Citation

Please use this url to cite or link to this publication:

Chicago
Brinkman, Brigitta, F Hildebrand, Malgorzata Kubica, D Goosens, J Del Favero, Wim Declercq, J Raes, and Peter Vandenabeele. 2011. “Caspase Deficiency Alters the Murine Gut Microbiome.” Cell Death & Disease 2.
APA
Brinkman, B., Hildebrand, F., Kubica, M., Goosens, D., Del Favero, J., Declercq, W., Raes, J., et al. (2011). Caspase deficiency alters the murine gut microbiome. CELL DEATH & DISEASE, 2.
Vancouver
1.
Brinkman B, Hildebrand F, Kubica M, Goosens D, Del Favero J, Declercq W, et al. Caspase deficiency alters the murine gut microbiome. CELL DEATH & DISEASE. 2011;2.
MLA
Brinkman, Brigitta, F Hildebrand, Malgorzata Kubica, et al. “Caspase Deficiency Alters the Murine Gut Microbiome.” CELL DEATH & DISEASE 2 (2011): n. pag. Print.
@article{1955082,
  abstract     = {Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.},
  articleno    = {e220},
  author       = {Brinkman, Brigitta and Hildebrand, F and Kubica, Malgorzata and Goosens, D and Del Favero, J and Declercq, Wim and Raes, J and Vandenabeele, Peter},
  issn         = {2041-4889},
  journal      = {CELL DEATH \& DISEASE},
  keyword      = {MICE,IL-1-BETA-CONVERTING ENZYME,DEFENSE,HEALTH,CHAIN FATTY-ACIDS,gut microbiome,caspase-3,pyrosequencing,caspase-7,caspase-1,knockout},
  language     = {eng},
  pages        = {6},
  title        = {Caspase deficiency alters the murine gut microbiome},
  url          = {http://dx.doi.org/10.1038/cddis.2011.101},
  volume       = {2},
  year         = {2011},
}

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