Ghent University Academic Bibliography

Advanced

Caspase deficiency alters the murine gut microbiome

Brigitta Brinkman UGent, F Hildebrand, Malgorzata Kubica UGent, D Goosens, J Del Favero, Wim Declercq UGent, J Raes and Peter Vandenabeele UGent (2011) CELL DEATH & DISEASE. 2.
abstract
Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
MICE, IL-1-BETA-CONVERTING ENZYME, DEFENSE, HEALTH, CHAIN FATTY-ACIDS, gut microbiome, caspase-3, pyrosequencing, caspase-7, caspase-1, knockout
journal title
CELL DEATH & DISEASE
Cell Death Dis.
volume
2
article number
e220
pages
6 pages
Web of Science type
Article
Web of Science id
000296587500009
JCR category
CELL BIOLOGY
JCR impact factor
5.333 (2011)
JCR rank
45/178 (2011)
JCR quartile
2 (2011)
ISSN
2041-4889
DOI
10.1038/cddis.2011.101
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1955082
handle
http://hdl.handle.net/1854/LU-1955082
date created
2011-11-28 15:25:52
date last changed
2016-12-21 15:41:57
@article{1955082,
  abstract     = {Caspases are aspartate-specific cysteine proteases that have an essential role in apoptosis and inflammation, and contribute to the maintenance of homeostasis in the intestine. These facts, together with the knowledge that caspases are implicated in host-microbe crosstalk, prompted us to investigate the effect of caspase (Casp) 1, -3 and -7 deficiency on the composition of the murine gut microbiota. We observed significant changes in the abundance of the Firmicutes and Bacteroidetes phyla, in particular the Lachnospiraceae, Porphyromonodaceae and Prevotellacea families, when comparing Casp-1, -7 and -3 knockout mice with wild-type mice. Our data point toward an intricate relationship between these caspases and the composition of the murine gut microflora.},
  articleno    = {e220},
  author       = {Brinkman, Brigitta and Hildebrand, F and Kubica, Malgorzata and Goosens, D and Del Favero, J and Declercq, Wim and Raes, J and Vandenabeele, Peter},
  issn         = {2041-4889},
  journal      = {CELL DEATH \& DISEASE},
  keyword      = {MICE,IL-1-BETA-CONVERTING ENZYME,DEFENSE,HEALTH,CHAIN FATTY-ACIDS,gut microbiome,caspase-3,pyrosequencing,caspase-7,caspase-1,knockout},
  language     = {eng},
  pages        = {6},
  title        = {Caspase deficiency alters the murine gut microbiome},
  url          = {http://dx.doi.org/10.1038/cddis.2011.101},
  volume       = {2},
  year         = {2011},
}

Chicago
Brinkman, Brigitta, F Hildebrand, Malgorzata Kubica, D Goosens, J Del Favero, Wim Declercq, J Raes, and Peter Vandenabeele. 2011. “Caspase Deficiency Alters the Murine Gut Microbiome.” Cell Death & Disease 2.
APA
Brinkman, B., Hildebrand, F., Kubica, M., Goosens, D., Del Favero, J., Declercq, W., Raes, J., et al. (2011). Caspase deficiency alters the murine gut microbiome. CELL DEATH & DISEASE, 2.
Vancouver
1.
Brinkman B, Hildebrand F, Kubica M, Goosens D, Del Favero J, Declercq W, et al. Caspase deficiency alters the murine gut microbiome. CELL DEATH & DISEASE. 2011;2.
MLA
Brinkman, Brigitta, F Hildebrand, Malgorzata Kubica, et al. “Caspase Deficiency Alters the Murine Gut Microbiome.” CELL DEATH & DISEASE 2 (2011): n. pag. Print.