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Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis

Peter Marhavy UGent, Agnieszka Bielach UGent, Lindy Abas, Anas Abuzeineh UGent, Jérôme Duclercq UGent, Hirokazu Tanaka UGent, Markéta Parezová, Jan Petrásek, Jiri Friml UGent and Jürgen Kleine-Vehn UGent, et al. (2011) DEVELOPMENTAL CELL. 21(4). p.796-804
abstract
Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
ARABIDOPSIS-THALIANA, SIGNAL-TRANSDUCTION, HORMONAL-CONTROL, ROOT GRAVITROPISM, TRANSPORT, ETHYLENE, LOCALIZATION, DEGRADATION, GROWTH, INITIATION
journal title
DEVELOPMENTAL CELL
Dev. Cell
volume
21
issue
4
pages
796 - 804
Web of Science type
Article
Web of Science id
000296366000021
JCR category
DEVELOPMENTAL BIOLOGY
JCR impact factor
14.03 (2011)
JCR rank
2/40 (2011)
JCR quartile
1 (2011)
ISSN
1534-5807
DOI
10.1016/j.devcel.2011.08.014
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1954359
handle
http://hdl.handle.net/1854/LU-1954359
date created
2011-11-25 16:52:00
date last changed
2011-11-30 09:37:21
@article{1954359,
  abstract     = {Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes.},
  author       = {Marhavy, Peter and Bielach, Agnieszka and Abas, Lindy and Abuzeineh, Anas and Duclercq, J{\'e}r{\^o}me and Tanaka, Hirokazu and Parezov{\'a}, Mark{\'e}ta and Petr{\'a}sek, Jan and Friml, Jiri and Kleine-Vehn, J{\"u}rgen and Benkova, Eva},
  issn         = {1534-5807},
  journal      = {DEVELOPMENTAL CELL},
  keyword      = {ARABIDOPSIS-THALIANA,SIGNAL-TRANSDUCTION,HORMONAL-CONTROL,ROOT GRAVITROPISM,TRANSPORT,ETHYLENE,LOCALIZATION,DEGRADATION,GROWTH,INITIATION},
  language     = {eng},
  number       = {4},
  pages        = {796--804},
  title        = {Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis},
  url          = {http://dx.doi.org/10.1016/j.devcel.2011.08.014},
  volume       = {21},
  year         = {2011},
}

Chicago
Marhavy, Peter, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jérôme Duclercq, Hirokazu Tanaka, Markéta Parezová, et al. 2011. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” Developmental Cell 21 (4): 796–804.
APA
Marhavy, P., Bielach, A., Abas, L., Abuzeineh, A., Duclercq, J., Tanaka, H., Parezová, M., et al. (2011). Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. DEVELOPMENTAL CELL, 21(4), 796–804.
Vancouver
1.
Marhavy P, Bielach A, Abas L, Abuzeineh A, Duclercq J, Tanaka H, et al. Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. DEVELOPMENTAL CELL. 2011;21(4):796–804.
MLA
Marhavy, Peter, Agnieszka Bielach, Lindy Abas, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” DEVELOPMENTAL CELL 21.4 (2011): 796–804. Print.