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Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis

(2011) DEVELOPMENTAL CELL. 21(4). p.796-804
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Abstract
Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes.
Keywords
ARABIDOPSIS-THALIANA, SIGNAL-TRANSDUCTION, HORMONAL-CONTROL, ROOT GRAVITROPISM, TRANSPORT, ETHYLENE, LOCALIZATION, DEGRADATION, GROWTH, INITIATION

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Citation

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Chicago
Marhavy, Peter, Agnieszka Bielach, Lindy Abas, Anas Abuzeineh, Jérôme Duclercq, Hirokazu Tanaka, Markéta Parezová, et al. 2011. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” Developmental Cell 21 (4): 796–804.
APA
Marhavy, P., Bielach, A., Abas, L., Abuzeineh, A., Duclercq, J., Tanaka, H., Parezová, M., et al. (2011). Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. DEVELOPMENTAL CELL, 21(4), 796–804.
Vancouver
1.
Marhavy P, Bielach A, Abas L, Abuzeineh A, Duclercq J, Tanaka H, et al. Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis. DEVELOPMENTAL CELL. 2011;21(4):796–804.
MLA
Marhavy, Peter, Agnieszka Bielach, Lindy Abas, et al. “Cytokinin Modulates Endocytic Trafficking of PIN1 Auxin Efflux Carrier to Control Plant Organogenesis.” DEVELOPMENTAL CELL 21.4 (2011): 796–804. Print.
@article{1954359,
  abstract     = {Cytokinin is an important regulator of plant growth and development. In Arabidopsis thaliana, the two-component phosphorelay mediated through a family of histidine kinases and response regulators is recognized as the principal cytokinin signal transduction mechanism activating the complex transcriptional response to control various developmental processes. Here, we identified an alternative mode of cytokinin action that uses endocytic trafficking as a means to direct plant organogenesis. This activity occurs downstream of known cytokinin receptors but through a branch of the cytokinin signaling pathway that does not involve transcriptional regulation. We show that cytokinin regulates endocytic recycling of the auxin efflux carrier PINFORMED1 (PIN1) by redirecting it for lytic degradation in vacuoles. Stimulation of the lytic PIN1 degradation is not a default effect for general downregulation of proteins from plasma membranes, but a specific mechanism to rapidly modulate the auxin distribution in cytokinin-mediated developmental processes.},
  author       = {Marhavy, Peter and Bielach, Agnieszka and Abas, Lindy and Abuzeineh, Anas and Duclercq, J{\'e}r{\^o}me and Tanaka, Hirokazu and Parezov{\'a}, Mark{\'e}ta and Petr{\'a}sek, Jan and Friml, Jiri and Kleine-Vehn, J{\"u}rgen and Benkova, Eva},
  issn         = {1534-5807},
  journal      = {DEVELOPMENTAL CELL},
  keyword      = {ARABIDOPSIS-THALIANA,SIGNAL-TRANSDUCTION,HORMONAL-CONTROL,ROOT GRAVITROPISM,TRANSPORT,ETHYLENE,LOCALIZATION,DEGRADATION,GROWTH,INITIATION},
  language     = {eng},
  number       = {4},
  pages        = {796--804},
  title        = {Cytokinin modulates endocytic trafficking of PIN1 auxin efflux carrier to control plant organogenesis},
  url          = {http://dx.doi.org/10.1016/j.devcel.2011.08.014},
  volume       = {21},
  year         = {2011},
}

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