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Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses

Stijn Schauvliege UGent, Miguel Gozalo Marcilla UGent, Kirsten Verryken UGent, Luc Duchateau UGent, Lindsey Devisscher UGent and Frank Gasthuys UGent (2011) VETERINARY ANAESTHESIA AND ANALGESIA. 38(6). p.544-554
abstract
Objective To examine the influence of a detomidine constant rate infusion (CRI) on cardiovascular function, isoflurane requirements and recovery quality in horses undergoing elective surgery. Study design Prospective, randomized, blinded, clinical trial. Animals Twenty adult healthy horses. Methods After sedation (detomidine, 10 mu g kg(-1) intravenously [IV]) and induction of anaesthesia (midazolam 0.06 mg kg(-1), ketamine 2.2 mg kg(-1) IV), anaesthesia was maintained with isoflurane in oxygen/air (inspiratory oxygen fraction 55%). When indicated, the lungs were mechanically ventilated. Dobutamine was administered when MAP < 70 mmHg. The horses were randomly allocated to one of two groups and throughout anaesthesia, received either a detomidine (5 mu g kg(-1) hour(-1)) (D) or saline (S) CRI, with the anaesthetist unaware of the treatment. Monitoring included end-tidal isoflurane concentration, arterial pH, PaCO(2), PaO(2), dobutamine administration rate, heart rate (HR), arterial pressure, cardiac index (CI), systemic vascular resistance (SVR), stroke index and oxygen delivery index ((D) over dotO(2)I). For recovery from anaesthesia, all horses received 2.5 mu g kg(-1) detomidine IV. Recovery quality and duration were recorded in each horse. For statistical analysis, ANOVA, Pearson chi-square and Wilcoxon rank sum tests were used as relevant. Results Heart rate (p = 0.0176) and (D) over dotO(2)I (p = 0.0084) were lower and SVR higher (p = 0.0126) in group D, compared to group S. Heart rate (p = 0.0011) and pH (p = 0.0187) increased over time. Significant differences in isoflurane requirements were not detected. Recovery quality and duration were comparable between treatments. Conclusions and clinical relevance A detomidine CRI produced cardiovascular effects typical for alpha(2)-agonists, without affecting isoflurane requirements, recovery duration or recovery quality.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cardiovascular, detomidine constant rate infusion, horses, isoflurane, recovery, ANESTHETIZED HORSES, XYLAZINE HYDROCHLORIDE, INHALANT ANESTHESIA, GENERAL-ANESTHESIA, MEDETOMIDINE, ROMIFIDINE, HALOTHANE, DOBUTAMINE, LIDOCAINE, KETAMINE
journal title
VETERINARY ANAESTHESIA AND ANALGESIA
Vet. Anaesth. Analg.
volume
38
issue
6
pages
544 - 554
Web of Science type
Article
Web of Science id
000295834300004
JCR category
VETERINARY SCIENCES
JCR impact factor
0.944 (2011)
JCR rank
58/141 (2011)
JCR quartile
2 (2011)
ISSN
1467-2987
DOI
10.1111/j.1467-2995.2011.00659.x
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1946660
handle
http://hdl.handle.net/1854/LU-1946660
date created
2011-11-22 14:30:28
date last changed
2011-11-24 16:32:46
@article{1946660,
  abstract     = {Objective To examine the influence of a detomidine constant rate infusion (CRI) on cardiovascular function, isoflurane requirements and recovery quality in horses undergoing elective surgery. 
Study design Prospective, randomized, blinded, clinical trial. 
Animals Twenty adult healthy horses. 
Methods After sedation (detomidine, 10 mu g kg(-1) intravenously [IV]) and induction of anaesthesia (midazolam 0.06 mg kg(-1), ketamine 2.2 mg kg(-1) IV), anaesthesia was maintained with isoflurane in oxygen/air (inspiratory oxygen fraction 55\%). When indicated, the lungs were mechanically ventilated. Dobutamine was administered when MAP {\textlangle} 70 mmHg. The horses were randomly allocated to one of two groups and throughout anaesthesia, received either a detomidine (5 mu g kg(-1) hour(-1)) (D) or saline (S) CRI, with the anaesthetist unaware of the treatment. Monitoring included end-tidal isoflurane concentration, arterial pH, PaCO(2), PaO(2), dobutamine administration rate, heart rate (HR), arterial pressure, cardiac index (CI), systemic vascular resistance (SVR), stroke index and oxygen delivery index ((D) over dotO(2)I). For recovery from anaesthesia, all horses received 2.5 mu g kg(-1) detomidine IV. Recovery quality and duration were recorded in each horse. For statistical analysis, ANOVA, Pearson chi-square and Wilcoxon rank sum tests were used as relevant. 
Results Heart rate (p = 0.0176) and (D) over dotO(2)I (p = 0.0084) were lower and SVR higher (p = 0.0126) in group D, compared to group S. Heart rate (p = 0.0011) and pH (p = 0.0187) increased over time. Significant differences in isoflurane requirements were not detected. Recovery quality and duration were comparable between treatments. 
Conclusions and clinical relevance A detomidine CRI produced cardiovascular effects typical for alpha(2)-agonists, without affecting isoflurane requirements, recovery duration or recovery quality.},
  author       = {Schauvliege, Stijn and Gozalo Marcilla, Miguel and Verryken, Kirsten and Duchateau, Luc and Devisscher, Lindsey and Gasthuys, Frank},
  issn         = {1467-2987},
  journal      = {VETERINARY ANAESTHESIA AND ANALGESIA},
  keyword      = {cardiovascular,detomidine constant rate infusion,horses,isoflurane,recovery,ANESTHETIZED HORSES,XYLAZINE HYDROCHLORIDE,INHALANT ANESTHESIA,GENERAL-ANESTHESIA,MEDETOMIDINE,ROMIFIDINE,HALOTHANE,DOBUTAMINE,LIDOCAINE,KETAMINE},
  language     = {eng},
  number       = {6},
  pages        = {544--554},
  title        = {Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses},
  url          = {http://dx.doi.org/10.1111/j.1467-2995.2011.00659.x},
  volume       = {38},
  year         = {2011},
}

Chicago
Schauvliege, Stijn, Miguel Gozalo Marcilla, Kirsten Verryken, Luc Duchateau, Lindsey Devisscher, and Frank Gasthuys. 2011. “Effects of a Constant Rate Infusion of Detomidine on Cardiovascular Function, Isoflurane Requirements and Recovery Quality in Horses.” Veterinary Anaesthesia and Analgesia 38 (6): 544–554.
APA
Schauvliege, S., Gozalo Marcilla, M., Verryken, K., Duchateau, L., Devisscher, L., & Gasthuys, F. (2011). Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses. VETERINARY ANAESTHESIA AND ANALGESIA, 38(6), 544–554.
Vancouver
1.
Schauvliege S, Gozalo Marcilla M, Verryken K, Duchateau L, Devisscher L, Gasthuys F. Effects of a constant rate infusion of detomidine on cardiovascular function, isoflurane requirements and recovery quality in horses. VETERINARY ANAESTHESIA AND ANALGESIA. 2011;38(6):544–54.
MLA
Schauvliege, Stijn, Miguel Gozalo Marcilla, Kirsten Verryken, et al. “Effects of a Constant Rate Infusion of Detomidine on Cardiovascular Function, Isoflurane Requirements and Recovery Quality in Horses.” VETERINARY ANAESTHESIA AND ANALGESIA 38.6 (2011): 544–554. Print.