Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling
- Author
- Kristof Kersse (UGent) , Mohamed Lamkanfi (UGent) , Mathieu Bertrand (UGent) , Tom Vanden Berghe (UGent) and Peter Vandenabeele (UGent)
- Organization
- Abstract
- Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction. Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation. Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.
- Keywords
- APOPTOSIS, INFLAMMATION, GENERATION, FORCE-FIELD, MICE DEFICIENT, CRYSTAL-STRUCTURE, CELL-DEATH, INTERLEUKIN-1-BETA CONVERTING-ENZYME, NMR STRUCTURE, DEATH DOMAIN
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Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1942020
- MLA
- Kersse, Kristof, et al. “Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-Interacting Protein 2 (RIP2)-Dependent Nuclear Factor ΚB Signaling.” JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 41, 2011, pp. 35874–82, doi:10.1074/jbc.M111.242321.
- APA
- Kersse, K., Lamkanfi, M., Bertrand, M., Vanden Berghe, T., & Vandenabeele, P. (2011). Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(41), 35874–35882. https://doi.org/10.1074/jbc.M111.242321
- Chicago author-date
- Kersse, Kristof, Mohamed Lamkanfi, Mathieu Bertrand, Tom Vanden Berghe, and Peter Vandenabeele. 2011. “Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-Interacting Protein 2 (RIP2)-Dependent Nuclear Factor ΚB Signaling.” JOURNAL OF BIOLOGICAL CHEMISTRY 286 (41): 35874–82. https://doi.org/10.1074/jbc.M111.242321.
- Chicago author-date (all authors)
- Kersse, Kristof, Mohamed Lamkanfi, Mathieu Bertrand, Tom Vanden Berghe, and Peter Vandenabeele. 2011. “Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-Interacting Protein 2 (RIP2)-Dependent Nuclear Factor ΚB Signaling.” JOURNAL OF BIOLOGICAL CHEMISTRY 286 (41): 35874–35882. doi:10.1074/jbc.M111.242321.
- Vancouver
- 1.Kersse K, Lamkanfi M, Bertrand M, Vanden Berghe T, Vandenabeele P. Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(41):35874–82.
- IEEE
- [1]K. Kersse, M. Lamkanfi, M. Bertrand, T. Vanden Berghe, and P. Vandenabeele, “Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling,” JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 41, pp. 35874–35882, 2011.
@article{1942020,
abstract = {{Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B.
Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction.
Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation.
Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.}},
author = {{Kersse, Kristof and Lamkanfi, Mohamed and Bertrand, Mathieu and Vanden Berghe, Tom and Vandenabeele, Peter}},
issn = {{0021-9258}},
journal = {{JOURNAL OF BIOLOGICAL CHEMISTRY}},
keywords = {{APOPTOSIS,INFLAMMATION,GENERATION,FORCE-FIELD,MICE DEFICIENT,CRYSTAL-STRUCTURE,CELL-DEATH,INTERLEUKIN-1-BETA CONVERTING-ENZYME,NMR STRUCTURE,DEATH DOMAIN}},
language = {{eng}},
number = {{41}},
pages = {{35874--35882}},
title = {{Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling}},
url = {{http://doi.org/10.1074/jbc.M111.242321}},
volume = {{286}},
year = {{2011}},
}
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