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Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling

(2011) JOURNAL OF BIOLOGICAL CHEMISTRY. 286(41). p.35874-35882
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Abstract
Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B. Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction. Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation. Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.
Keywords
APOPTOSIS, INFLAMMATION, GENERATION, FORCE-FIELD, MICE DEFICIENT, CRYSTAL-STRUCTURE, CELL-DEATH, INTERLEUKIN-1-BETA CONVERTING-ENZYME, NMR STRUCTURE, DEATH DOMAIN

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Citation

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Chicago
Kersse, Kristof, Mohamed Lamkanfi, Mathieu Bertrand, Tom Vanden Berghe, and Peter Vandenabeele. 2011. “Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent Nuclear Factor κB Signaling.” Journal of Biological Chemistry 286 (41): 35874–35882.
APA
Kersse, K., Lamkanfi, M., Bertrand, M., Vanden Berghe, T., & Vandenabeele, P. (2011). Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling. JOURNAL OF BIOLOGICAL CHEMISTRY, 286(41), 35874–35882.
Vancouver
1.
Kersse K, Lamkanfi M, Bertrand M, Vanden Berghe T, Vandenabeele P. Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor κB signaling. JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(41):35874–82.
MLA
Kersse, Kristof, Mohamed Lamkanfi, Mathieu Bertrand, et al. “Interaction Patches of Procaspase-1 Caspase Recruitment Domains (CARDs) Are Differently Involved in Procaspase-1 Activation and Receptor-interacting Protein 2 (RIP2)-dependent Nuclear Factor κB Signaling.” JOURNAL OF BIOLOGICAL CHEMISTRY 286.41 (2011): 35874–35882. Print.
@article{1942020,
  abstract     = {Background: The CARD of procaspase-1 regulates activation of procaspase-1 and NF-kappa B.
Results: We show that the CARD procaspase-1 interacts with ASC through a type I interaction, whereas RIP2-mediated NF-kappa B activation involves a type III interaction.
Conclusion: These findings indicate that the CARD of procaspase-1 is differently involved in inflammasome formation and NF-kappa B activation.
Significance: These findings may allow development of therapeutics that specifically target a procaspase-1 function.},
  author       = {Kersse, Kristof and Lamkanfi, Mohamed and Bertrand, Mathieu and Vanden Berghe, Tom and Vandenabeele, Peter},
  issn         = {0021-9258},
  journal      = {JOURNAL OF BIOLOGICAL CHEMISTRY},
  keyword      = {APOPTOSIS,INFLAMMATION,GENERATION,FORCE-FIELD,MICE DEFICIENT,CRYSTAL-STRUCTURE,CELL-DEATH,INTERLEUKIN-1-BETA CONVERTING-ENZYME,NMR STRUCTURE,DEATH DOMAIN},
  language     = {eng},
  number       = {41},
  pages        = {35874--35882},
  title        = {Interaction patches of procaspase-1 caspase recruitment domains (CARDs) are differently involved in procaspase-1 activation and receptor-interacting protein 2 (RIP2)-dependent nuclear factor \ensuremath{\kappa}B signaling},
  url          = {http://dx.doi.org/10.1074/jbc.M111.242321},
  volume       = {286},
  year         = {2011},
}

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