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Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and Tryptophan challenge

C Rob Markus and Rudi De Raedt UGent (2011) NEUROPSYCHOPHARMACOLOGY. 36(4). p.819-826
abstract
Previous data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-HT dysfunction and stress exposure. Although attentional bias for emotional information has been reliably observed in depression, the interaction between 5-HT transporter-linked promoter region (5-HTTLPR), brain 5-HT vulnerability, and acute stress on affective information processing has not yet been investigated. This study examines the effects of tryptophan (TRP) augmentation (indicating 5-HT manipulation) on inhibition of negative emotional information under stress in mainly female S'/S'-vs L'/L'-allele carriers. A total of 15 female homozygotic short-allele 5-HTTLPR (S'/S' S/S, S/L(G), L(G)/L(G)) and 13 female homozygotic long-allele 5-HTTLPR (L'/L' L(A)/L(A)) subjects were tested for mood and inhibition of emotional information in a double-blind, placebo-controlled design before and after stress exposure following TRP manipulation. Stress exposure significantly impaired inhibition of negative affective information only in S'/S' carriers, whereas L'/L' carriers even showed increased inhibition of negative information. The S'/S' allele 5-HTTLPR genotype increases cognitive-attentional bias for negative emotional information under acute stress. As this bias is an important component of depression, this may be a mediating mechanism making S'/S'-allele carriers more vulnerability for stress-induced depression symptoms. Moreover, current data suggest that L'/L'-allele genotypes are more resilient, even increasing cognitive emotional (inhibitory) control after stress. Neuropsychopharmacology (2011) 36, 819-826; doi:10.1038/npp.2010.221; published online 8 December 2010
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PROMOTER POLYMORPHISM 5-HTTLPR, SEROTONIN TRANSPORTER GENE, MAJOR DEPRESSION, 5-HYDROXYINDOLEACETIC ACID, UNIPOLAR DEPRESSION, LIFE EVENTS, ANTIDEPRESSANT ACTION, CEREBROSPINAL-FLUID, HEALTHY-VOLUNTEERS, BRAIN TRYPTOPHAN, 5-HTTLPR, emotion processing, serotonin, stress, tryptophan
journal title
NEUROPSYCHOPHARMACOLOGY
Neuropsychopharmacology
volume
36
issue
4
pages
819 - 826
Web of Science type
Article
Web of Science id
000287188200010
JCR category
PHARMACOLOGY & PHARMACY
JCR impact factor
7.991 (2011)
JCR rank
9/259 (2011)
JCR quartile
1 (2011)
ISSN
0893-133X
DOI
10.1038/npp.2010.221
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1940901
handle
http://hdl.handle.net/1854/LU-1940901
date created
2011-11-09 15:58:48
date last changed
2016-12-19 15:46:40
@article{1940901,
  abstract     = {Previous data suggest that a polymorphism at the serotonin (5-HT) transporter gene (5-HTTLPR) may influence stress resilience and stress-related depression symptoms due to interactions between brain 5-HT dysfunction and stress exposure. Although attentional bias for emotional information has been reliably observed in depression, the interaction between 5-HT transporter-linked promoter region (5-HTTLPR), brain 5-HT vulnerability, and acute stress on affective information processing has not yet been investigated. This study examines the effects of tryptophan (TRP) augmentation (indicating 5-HT manipulation) on inhibition of negative emotional information under stress in mainly female S'/S'-vs L'/L'-allele carriers. A total of 15 female homozygotic short-allele 5-HTTLPR (S'/S' S/S, S/L(G), L(G)/L(G)) and 13 female homozygotic long-allele 5-HTTLPR (L'/L' L(A)/L(A)) subjects were tested for mood and inhibition of emotional information in a double-blind, placebo-controlled design before and after stress exposure following TRP manipulation. Stress exposure significantly impaired inhibition of negative affective information only in S'/S' carriers, whereas L'/L' carriers even showed increased inhibition of negative information. The S'/S' allele 5-HTTLPR genotype increases cognitive-attentional bias for negative emotional information under acute stress. As this bias is an important component of depression, this may be a mediating mechanism making S'/S'-allele carriers more vulnerability for stress-induced depression symptoms. Moreover, current data suggest that L'/L'-allele genotypes are more resilient, even increasing cognitive emotional (inhibitory) control after stress. Neuropsychopharmacology (2011) 36, 819-826; doi:10.1038/npp.2010.221; published online 8 December 2010},
  author       = {Markus, C Rob and De Raedt, Rudi},
  issn         = {0893-133X},
  journal      = {NEUROPSYCHOPHARMACOLOGY},
  keyword      = {PROMOTER POLYMORPHISM 5-HTTLPR,SEROTONIN TRANSPORTER GENE,MAJOR DEPRESSION,5-HYDROXYINDOLEACETIC ACID,UNIPOLAR DEPRESSION,LIFE EVENTS,ANTIDEPRESSANT ACTION,CEREBROSPINAL-FLUID,HEALTHY-VOLUNTEERS,BRAIN TRYPTOPHAN,5-HTTLPR,emotion processing,serotonin,stress,tryptophan},
  language     = {eng},
  number       = {4},
  pages        = {819--826},
  title        = {Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and Tryptophan challenge},
  url          = {http://dx.doi.org/10.1038/npp.2010.221},
  volume       = {36},
  year         = {2011},
}

Chicago
Markus, C Rob, and Rudi De Raedt. 2011. “Differential Effects of 5-HTTLPR Genotypes on Inhibition of Negative Emotional Information Following Acute Stress Exposure and Tryptophan Challenge.” Neuropsychopharmacology 36 (4): 819–826.
APA
Markus, C. R., & De Raedt, R. (2011). Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and Tryptophan challenge. NEUROPSYCHOPHARMACOLOGY, 36(4), 819–826.
Vancouver
1.
Markus CR, De Raedt R. Differential effects of 5-HTTLPR genotypes on inhibition of negative emotional information following acute stress exposure and Tryptophan challenge. NEUROPSYCHOPHARMACOLOGY. 2011;36(4):819–26.
MLA
Markus, C Rob, and Rudi De Raedt. “Differential Effects of 5-HTTLPR Genotypes on Inhibition of Negative Emotional Information Following Acute Stress Exposure and Tryptophan Challenge.” NEUROPSYCHOPHARMACOLOGY 36.4 (2011): 819–826. Print.