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The neu-protein and breast cancer

Christian De Potter and Anne-Marie Schelfhout
(1995) VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY. 426(2). p.107-115
Author
Organization
Abstract
The neu-protein is overexpressed in about 20% of invasive duct cell carcinomas of the breast. The only reliable sign for neu-overexpression by immunohistochemistry is membrane staining. Its overexpression is correlated with decreased overall survival and disease free survival due to increased metastatic activity of neu-overexpressing tumour cells. This increased metastatic potential is a consequence of the motility enhancing activity of the neu-protein, which is exclusively expressed on pseudopodia, and to a lesser extent of its growth stimulating effect. From a clinical point of view, the assessment of neu-overexpression in breast cancer might become a useful tool in the future treatment of patients by chemotherapy, since patients whose tumour shows neu-overexpression benefit from higher doses of chemotherapy. The molecule plays a key role in the pathogenesis of Paget's disease of the breast. A chemotactic factor which is secreted by epidermal keratinocytes attracts the Paget cells to spread into the epidermis and acts via the neu-protein. In ductal carcinoma in situ, the combination of neu-overexpression and large cell type is highly correlated with extent of disease and therefore neu-overexpression might be a predictive marker for recurrence of disease after tumour resection.
Keywords
NEU, C-ERBB2, ONCOGENE, BREAST CANCER, PAGETS DISEASE, GROWTH-FACTOR-RECEPTOR, DUCTAL CARCINOMA INSITU, C-ERBB-2 ONCOPROTEIN EXPRESSION, EXTRAMAMMARY PAGETS-DISEASE, ERBB-RELATED GENE, ONCOGENE PRODUCT, EGF RECEPTOR, ESTROGEN-RECEPTOR, IMMUNOHISTOCHEMICAL DEMONSTRATION, TYROSINE PHOSPHORYLATION

Citation

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MLA
De Potter, Christian, and Anne-Marie Schelfhout. “The Neu-Protein and Breast Cancer.” VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, vol. 426, no. 2, 1995, pp. 107–15, doi:10.1007/BF00192631.
APA
De Potter, C., & Schelfhout, A.-M. (1995). The neu-protein and breast cancer. VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, 426(2), 107–115. https://doi.org/10.1007/BF00192631
Chicago author-date
De Potter, Christian, and Anne-Marie Schelfhout. 1995. “The Neu-Protein and Breast Cancer.” VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 426 (2): 107–15. https://doi.org/10.1007/BF00192631.
Chicago author-date (all authors)
De Potter, Christian, and Anne-Marie Schelfhout. 1995. “The Neu-Protein and Breast Cancer.” VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY 426 (2): 107–115. doi:10.1007/BF00192631.
Vancouver
1.
De Potter C, Schelfhout A-M. The neu-protein and breast cancer. VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY. 1995;426(2):107–15.
IEEE
[1]
C. De Potter and A.-M. Schelfhout, “The neu-protein and breast cancer,” VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY, vol. 426, no. 2, pp. 107–115, 1995.
@article{193720,
  abstract     = {{The neu-protein is overexpressed in about 20% of invasive duct cell carcinomas of the breast. The only reliable sign for neu-overexpression by immunohistochemistry is membrane staining. Its overexpression is correlated with decreased overall survival and disease free survival due to increased metastatic activity of neu-overexpressing tumour cells. This increased metastatic potential is a consequence of the motility enhancing activity of the neu-protein, which is exclusively expressed on pseudopodia, and to a lesser extent of its growth stimulating effect. From a clinical point of view, the assessment of neu-overexpression in breast cancer might become a useful tool in the future treatment of patients by chemotherapy, since patients whose tumour shows neu-overexpression benefit from higher doses of chemotherapy. The molecule plays a key role in the pathogenesis of Paget's disease of the breast. A chemotactic factor which is secreted by epidermal keratinocytes attracts the Paget cells to spread into the epidermis and acts via the neu-protein. In ductal carcinoma in situ, the combination of neu-overexpression and large cell type is highly correlated with extent of disease and therefore neu-overexpression might be a predictive marker for recurrence of disease after tumour resection.}},
  author       = {{De Potter, Christian and Schelfhout, Anne-Marie}},
  issn         = {{0945-6317}},
  journal      = {{VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY}},
  keywords     = {{NEU,C-ERBB2,ONCOGENE,BREAST CANCER,PAGETS DISEASE,GROWTH-FACTOR-RECEPTOR,DUCTAL CARCINOMA INSITU,C-ERBB-2 ONCOPROTEIN EXPRESSION,EXTRAMAMMARY PAGETS-DISEASE,ERBB-RELATED GENE,ONCOGENE PRODUCT,EGF RECEPTOR,ESTROGEN-RECEPTOR,IMMUNOHISTOCHEMICAL DEMONSTRATION,TYROSINE PHOSPHORYLATION}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{107--115}},
  title        = {{The neu-protein and breast cancer}},
  url          = {{http://dx.doi.org/10.1007/BF00192631}},
  volume       = {{426}},
  year         = {{1995}},
}
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