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Grey matter volume correlates with virtual water maze task performance in boys with androgen excess

Sven Müller (UGent) , Deborah P Merke, Ellen W Leschek, Stephen Fromm, C Grillon, BR Cornwell, C Vanryzin and M Ernst
(2011) NEUROSCIENCE. 197. p.225-232
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Abstract
Major questions remain about the specific role of testosterone in human spatial navigation. We tested 10 boys (mean age 11.65 years) with an extremely rare disorder of androgen excess (Familial Male Precocious Puberty, FMPP) and 40 healthy boys (mean age 12.81 years) on a virtual version of the Morris Water Maze task. In addition, anatomical magnetic resonance images were collected for all patients and a subsample of the controls (n=21) after task completion. Behaviourally, no significant differences were found between both groups. However, in the MRI analyses, grey matter volume (GMV) was correlated with performance using voxel-based morphometry (VBM). Group differences in correlations of performance with GMV were apparent in medial regions of the prefrontal cortex as well as the middle occipital gyrus and the cuneus. By comparison, similar correlations for both groups were found in the inferior parietal lobule. These data provide novel insight into the relation between testosterone and brain development and suggest that morphological differences in a spatial navigation network covary with performance in spatial ability. Published by Elsevier Ltd on behalf of IBRO.
Keywords
spatial navigation, testosterone, development, familial male precocious puberty, VBM, virtual water maze, CONGENITAL ADRENAL-HYPERPLASIA, VOXEL-BASED MORPHOMETRY, MEDIAL TEMPORAL-LOBE, SPATIAL NAVIGATION, HIPPOCAMPAL FUNCTION, PRECOCIOUS PUBERTY, STEROID-HORMONES, PARIETAL CORTEX, SEX-DIFFERENCES, BRAIN

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MLA
Müller, Sven, et al. “Grey Matter Volume Correlates with Virtual Water Maze Task Performance in Boys with Androgen Excess.” NEUROSCIENCE, vol. 197, 2011, pp. 225–32, doi:10.1016/j.neuroscience.2011.09.022.
APA
Müller, S., Merke, D. P., Leschek, E. W., Fromm, S., Grillon, C., Cornwell, B., … Ernst, M. (2011). Grey matter volume correlates with virtual water maze task performance in boys with androgen excess. NEUROSCIENCE, 197, 225–232. https://doi.org/10.1016/j.neuroscience.2011.09.022
Chicago author-date
Müller, Sven, Deborah P Merke, Ellen W Leschek, Stephen Fromm, C Grillon, BR Cornwell, C Vanryzin, and M Ernst. 2011. “Grey Matter Volume Correlates with Virtual Water Maze Task Performance in Boys with Androgen Excess.” NEUROSCIENCE 197: 225–32. https://doi.org/10.1016/j.neuroscience.2011.09.022.
Chicago author-date (all authors)
Müller, Sven, Deborah P Merke, Ellen W Leschek, Stephen Fromm, C Grillon, BR Cornwell, C Vanryzin, and M Ernst. 2011. “Grey Matter Volume Correlates with Virtual Water Maze Task Performance in Boys with Androgen Excess.” NEUROSCIENCE 197: 225–232. doi:10.1016/j.neuroscience.2011.09.022.
Vancouver
1.
Müller S, Merke DP, Leschek EW, Fromm S, Grillon C, Cornwell B, et al. Grey matter volume correlates with virtual water maze task performance in boys with androgen excess. NEUROSCIENCE. 2011;197:225–32.
IEEE
[1]
S. Müller et al., “Grey matter volume correlates with virtual water maze task performance in boys with androgen excess,” NEUROSCIENCE, vol. 197, pp. 225–232, 2011.
@article{1932533,
  abstract     = {{Major questions remain about the specific role of testosterone in human spatial navigation. We tested 10 boys (mean age 11.65 years) with an extremely rare disorder of androgen excess (Familial Male Precocious Puberty, FMPP) and 40 healthy boys (mean age 12.81 years) on a virtual version of the Morris Water Maze task. In addition, anatomical magnetic resonance images were collected for all patients and a subsample of the controls (n=21) after task completion. Behaviourally, no significant differences were found between both groups. However, in the MRI analyses, grey matter volume (GMV) was correlated with performance using voxel-based morphometry (VBM). Group differences in correlations of performance with GMV were apparent in medial regions of the prefrontal cortex as well as the middle occipital gyrus and the cuneus. By comparison, similar correlations for both groups were found in the inferior parietal lobule. These data provide novel insight into the relation between testosterone and brain development and suggest that morphological differences in a spatial navigation network covary with performance in spatial ability. Published by Elsevier Ltd on behalf of IBRO.}},
  author       = {{Müller, Sven and Merke, Deborah P and Leschek, Ellen W and Fromm, Stephen and Grillon, C and Cornwell, BR and Vanryzin, C and Ernst, M}},
  issn         = {{0306-4522}},
  journal      = {{NEUROSCIENCE}},
  keywords     = {{spatial navigation,testosterone,development,familial male precocious puberty,VBM,virtual water maze,CONGENITAL ADRENAL-HYPERPLASIA,VOXEL-BASED MORPHOMETRY,MEDIAL TEMPORAL-LOBE,SPATIAL NAVIGATION,HIPPOCAMPAL FUNCTION,PRECOCIOUS PUBERTY,STEROID-HORMONES,PARIETAL CORTEX,SEX-DIFFERENCES,BRAIN}},
  language     = {{eng}},
  pages        = {{225--232}},
  title        = {{Grey matter volume correlates with virtual water maze task performance in boys with androgen excess}},
  url          = {{http://doi.org/10.1016/j.neuroscience.2011.09.022}},
  volume       = {{197}},
  year         = {{2011}},
}
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