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Abdominal aortic calcification detected by dual X-ray absorptiometry: a strong predictor for cardiovascular events

(2010) ANNALS OF MEDICINE. 42(7). p.539-545
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Abstract
Background. Vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry can visualize abdominal aortic calcification (AAC). AAC correlates with total atherosclerosis burden. We questioned whether VFA-detected AAC could be used for cardiovascular risk assessment. Methods. VFA images of 2,500 subjects were evaluated to detect and score AAC (n = 164). A random age- and gender-matched set of subjects (n = 325) without AAC served as control group. Patients with prior cardiovascular disease or procedures were excluded. Base-line cardiovascular risk factors and further cardiovascular events were checked. Design-based Cox regression analysis was used to examine the prognostic value of AAC for cardiovascular outcomes. Results. AAC-positive subjects were divided into two groups: low-AAC (score 1-3), and high-AAC group (score > 3). Mean age in the groups was 68, 68, and 71 years, percentage of females was 64.4%, 61%, and 66.1%, and the proportion of cardiovascular events within groups was 1.5%, 6.7%, and 11.9% in control, low-AAC, and high-AAC groups, respectively. Age- and gender-adjusted as well as multivariable analysis showed a significant, higher risk for cardiovascular events incidence in AAC-positive, low-AAC, and high-AAC when compared to the control group. Interpretation. AAC assessed with routine VFA was shown to be a strong predictor for cardiovascular events.
Keywords
ROTTERDAM, DEPOSITS, ANTHROPOMETRY, ATHEROSCLEROSIS, DISEASE, COMPUTED-TOMOGRAPHY, POSTMENOPAUSAL WOMEN, RISK-FACTORS, INCIDENT MYOCARDIAL-INFARCTION, VFA, DEXA, cardiovascular event, abdominal aortic calcification, AAC, FAT

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Chicago
Golestani, Reza, René A Tio, Clark J Zeebregts, Aafke Zeilstra, Rudi Dierckx, Hendrikus H Boersma, Hans L Hillege, and Riemer HJA Slart. 2010. “Abdominal Aortic Calcification Detected by Dual X-ray Absorptiometry: a Strong Predictor for Cardiovascular Events.” Annals of Medicine 42 (7): 539–545.
APA
Golestani, Reza, Tio, R. A., Zeebregts, C. J., Zeilstra, A., Dierckx, R., Boersma, H. H., Hillege, H. L., et al. (2010). Abdominal aortic calcification detected by dual X-ray absorptiometry: a strong predictor for cardiovascular events. ANNALS OF MEDICINE, 42(7), 539–545.
Vancouver
1.
Golestani R, Tio RA, Zeebregts CJ, Zeilstra A, Dierckx R, Boersma HH, et al. Abdominal aortic calcification detected by dual X-ray absorptiometry: a strong predictor for cardiovascular events. ANNALS OF MEDICINE. 2010;42(7):539–45.
MLA
Golestani, Reza, René A Tio, Clark J Zeebregts, et al. “Abdominal Aortic Calcification Detected by Dual X-ray Absorptiometry: a Strong Predictor for Cardiovascular Events.” ANNALS OF MEDICINE 42.7 (2010): 539–545. Print.
@article{1931326,
  abstract     = {Background. Vertebral fracture assessment (VFA) using dual-energy X-ray absorptiometry can visualize abdominal aortic calcification (AAC). AAC correlates with total atherosclerosis burden. We questioned whether VFA-detected AAC could be used for cardiovascular risk assessment. 
Methods. VFA images of 2,500 subjects were evaluated to detect and score AAC (n = 164). A random age- and gender-matched set of subjects (n = 325) without AAC served as control group. Patients with prior cardiovascular disease or procedures were excluded. Base-line cardiovascular risk factors and further cardiovascular events were checked. Design-based Cox regression analysis was used to examine the prognostic value of AAC for cardiovascular outcomes. 
Results. AAC-positive subjects were divided into two groups: low-AAC (score 1-3), and high-AAC group (score > 3). Mean age in the groups was 68, 68, and 71 years, percentage of females was 64.4%, 61%, and 66.1%, and the proportion of cardiovascular events within groups was 1.5%, 6.7%, and 11.9% in control, low-AAC, and high-AAC groups, respectively. Age- and gender-adjusted as well as multivariable analysis showed a significant, higher risk for cardiovascular events incidence in AAC-positive, low-AAC, and high-AAC when compared to the control group. 
Interpretation. AAC assessed with routine VFA was shown to be a strong predictor for cardiovascular events.},
  author       = {Golestani, Reza and Tio, René A and Zeebregts, Clark J and Zeilstra, Aafke and Dierckx, Rudi and Boersma, Hendrikus H and Hillege, Hans L and Slart, Riemer HJA},
  issn         = {0785-3890},
  journal      = {ANNALS OF MEDICINE},
  keywords     = {ROTTERDAM,DEPOSITS,ANTHROPOMETRY,ATHEROSCLEROSIS,DISEASE,COMPUTED-TOMOGRAPHY,POSTMENOPAUSAL WOMEN,RISK-FACTORS,INCIDENT MYOCARDIAL-INFARCTION,VFA,DEXA,cardiovascular event,abdominal aortic calcification,AAC,FAT},
  language     = {eng},
  number       = {7},
  pages        = {539--545},
  title        = {Abdominal aortic calcification detected by dual X-ray absorptiometry: a strong predictor for cardiovascular events},
  url          = {http://dx.doi.org/10.3109/07853890.2010.515604},
  volume       = {42},
  year         = {2010},
}

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