Advanced search
1 file | 335.54 KB Add to list

Increased medial temporal lobe and striatal grey matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study

Author
Organization
Abstract
Major questions remain about how sex hormones influence human brain development and cognition. Studies in humans and animals suggest a strong impact of androgen on the structure and function of the medial temporal lobe (MTL) and striatum. Using voxel-based morphometry (DARTEL), we compared MTL and striatal structures in 13 [ mean age (+/- S.D.) 12.7 +/- 3.2 yr, mean bone age 14.8 +/- 3.2 yr] boys with familial male precocious puberty (FMPP), characterized by early excess androgen secretion, and 39 healthy age-matched boys (mean age 14.3 +/- 2.5 yr). The FMPP group showed significantly larger grey-matter volume (GMV) in parahippocampal and fusiform gyri as well as putamen relative to controls. By comparison, larger GMV for controls relative to patients was only apparent in the precentral gyrus. Exploratory regression analyses that examined the impact of age on the current findings revealed a significant increase of GMV in the putamen with age in patients suffering from excess androgen but not in controls. Finally, current levels of free testosterone were obtained in the patient group. Analyses revealed a significant negative association indicating that FMPP boys with low levels of bioavailable testosterone exhibited high GMV in the bilateral striatum. The findings suggest a critical influence of androgen on human brain development and are discussed in relation to male-dominant psychiatric childhood disorders.
Keywords
CONGENITAL ADRENAL-HYPERPLASIA, ATTENTION-DEFICIT/HYPERACTIVITY DISORDER, MALE PRECOCIOUS PUBERTY, LUTEINIZING-HORMONE RECEPTOR, LONG-TERM TREATMENT, FUSIFORM FACE AREA, STEROID-HORMONES, SEX-DIFFERENCES, MALE-RATS, DEVELOPMENTAL TRAJECTORIES, ADHD, brain development, FMPP, precocious puberty, sex steroid

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 335.54 KB

Citation

Please use this url to cite or link to this publication:

MLA
Müller, Sven, Deborah Merke, Ellen Leschek, et al. “Increased Medial Temporal Lobe and Striatal Grey Matter Volume in a Rare Disorder of Androgen Excess: a Voxel-based Morphometry (VBM) Study.” INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY 14.4 (2011): 445–457. Print.
APA
Müller, Sven, Merke, D., Leschek, E., VanRyzin, C., Fromm, S., & Ernst, M. (2011). Increased medial temporal lobe and striatal grey matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 14(4), 445–457.
Chicago author-date
Müller, Sven, Deborah Merke, Ellen Leschek, Carol VanRyzin, Stephen Fromm, and Monique Ernst. 2011. “Increased Medial Temporal Lobe and Striatal Grey Matter Volume in a Rare Disorder of Androgen Excess: a Voxel-based Morphometry (VBM) Study.” International Journal of Neuropsychopharmacology 14 (4): 445–457.
Chicago author-date (all authors)
Müller, Sven, Deborah Merke, Ellen Leschek, Carol VanRyzin, Stephen Fromm, and Monique Ernst. 2011. “Increased Medial Temporal Lobe and Striatal Grey Matter Volume in a Rare Disorder of Androgen Excess: a Voxel-based Morphometry (VBM) Study.” International Journal of Neuropsychopharmacology 14 (4): 445–457.
Vancouver
1.
Müller S, Merke D, Leschek E, VanRyzin C, Fromm S, Ernst M. Increased medial temporal lobe and striatal grey matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2011;14(4):445–57.
IEEE
[1]
S. Müller, D. Merke, E. Leschek, C. VanRyzin, S. Fromm, and M. Ernst, “Increased medial temporal lobe and striatal grey matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study,” INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, vol. 14, no. 4, pp. 445–457, 2011.
@article{1929271,
  abstract     = {{Major questions remain about how sex hormones influence human brain development and cognition. Studies in humans and animals suggest a strong impact of androgen on the structure and function of the medial temporal lobe (MTL) and striatum. Using voxel-based morphometry (DARTEL), we compared MTL and striatal structures in 13 [ mean age (+/- S.D.) 12.7 +/- 3.2 yr, mean bone age 14.8 +/- 3.2 yr] boys with familial male precocious puberty (FMPP), characterized by early excess androgen secretion, and 39 healthy age-matched boys (mean age 14.3 +/- 2.5 yr). The FMPP group showed significantly larger grey-matter volume (GMV) in parahippocampal and fusiform gyri as well as putamen relative to controls. By comparison, larger GMV for controls relative to patients was only apparent in the precentral gyrus. Exploratory regression analyses that examined the impact of age on the current findings revealed a significant increase of GMV in the putamen with age in patients suffering from excess androgen but not in controls. Finally, current levels of free testosterone were obtained in the patient group. Analyses revealed a significant negative association indicating that FMPP boys with low levels of bioavailable testosterone exhibited high GMV in the bilateral striatum. The findings suggest a critical influence of androgen on human brain development and are discussed in relation to male-dominant psychiatric childhood disorders.}},
  author       = {{Müller, Sven and Merke, Deborah and Leschek, Ellen and VanRyzin, Carol and Fromm, Stephen and Ernst, Monique}},
  issn         = {{1461-1457}},
  journal      = {{INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY}},
  keywords     = {{CONGENITAL ADRENAL-HYPERPLASIA,ATTENTION-DEFICIT/HYPERACTIVITY DISORDER,MALE PRECOCIOUS PUBERTY,LUTEINIZING-HORMONE RECEPTOR,LONG-TERM TREATMENT,FUSIFORM FACE AREA,STEROID-HORMONES,SEX-DIFFERENCES,MALE-RATS,DEVELOPMENTAL TRAJECTORIES,ADHD,brain development,FMPP,precocious puberty,sex steroid}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{445--457}},
  title        = {{Increased medial temporal lobe and striatal grey matter volume in a rare disorder of androgen excess: a voxel-based morphometry (VBM) study}},
  url          = {{http://dx.doi.org/10.1017/S1461145710001136}},
  volume       = {{14}},
  year         = {{2011}},
}

Altmetric
View in Altmetric
Web of Science
Times cited: