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Perturbed reward processing in pediatric bipolar disorder: an antisaccade study

Sven Müller (UGent) , Pamela Ng, Veronika Temple, Michael Hardin, Daniel Pine, Ellen Leibenluft and Monique Ernst
(2010) JOURNAL OF PSYCHOPHARMACOLOGY. 24(12). p.1779-1784
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Abstract
Pediatric bipolar disorder is a severe and impairing illness. Characterizing the impact of pediatric bipolar disorder on cognitive function might aid in understanding the phenomenology of the disorder. While previous studies of pediatric bipolar disorder have reported deficits in cognitive control and reward behavior, little is understood about how affective processes influence behavioral control. Relative to prior studies using manual-response paradigms, eye movement tasks provide a more precise assessment of reward sensitivity and cognitive and motor control. The current study compares 20 youths with bipolar disorder (mean age = 13.9 years +/- 2.22) and 23 healthy subjects (mean age = 13.8 years +/- 2.49) on a mixed pro-antisaccade task with monetary incentives. On both types of saccades, participants were presented with three types of incentives: those where subjects can win money, lose money, or neither win nor lose money. Impaired reward processing was found in youths with bipolar disorder relative to controls, particularly on antisaccades. This difference was reflected in lower error rates during incentive trials in the control but not in the bipolar disorder group. By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder.
Keywords
DEFICIT HYPERACTIVITY DISORDER, SACCADIC EYE-MOVEMENTS, SEVERE MOOD DYSREGULATION, COGNITIVE CONTROL, DEPRESSED ADOLESCENTS, VOLUNTARY CONTROL, SCHIZOPHRENIA, TASK, PSYCHOPATHOLOGY, CONTINGENCIES, bipolar disorder, reward, antisaccade, cognitive control, emotion, ADHD

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MLA
Müller, Sven, et al. “Perturbed Reward Processing in Pediatric Bipolar Disorder: An Antisaccade Study.” JOURNAL OF PSYCHOPHARMACOLOGY, vol. 24, no. 12, 2010, pp. 1779–84, doi:10.1177/0269881109353462.
APA
Müller, S., Ng, P., Temple, V., Hardin, M., Pine, D., Leibenluft, E., & Ernst, M. (2010). Perturbed reward processing in pediatric bipolar disorder: an antisaccade study. JOURNAL OF PSYCHOPHARMACOLOGY, 24(12), 1779–1784. https://doi.org/10.1177/0269881109353462
Chicago author-date
Müller, Sven, Pamela Ng, Veronika Temple, Michael Hardin, Daniel Pine, Ellen Leibenluft, and Monique Ernst. 2010. “Perturbed Reward Processing in Pediatric Bipolar Disorder: An Antisaccade Study.” JOURNAL OF PSYCHOPHARMACOLOGY 24 (12): 1779–84. https://doi.org/10.1177/0269881109353462.
Chicago author-date (all authors)
Müller, Sven, Pamela Ng, Veronika Temple, Michael Hardin, Daniel Pine, Ellen Leibenluft, and Monique Ernst. 2010. “Perturbed Reward Processing in Pediatric Bipolar Disorder: An Antisaccade Study.” JOURNAL OF PSYCHOPHARMACOLOGY 24 (12): 1779–1784. doi:10.1177/0269881109353462.
Vancouver
1.
Müller S, Ng P, Temple V, Hardin M, Pine D, Leibenluft E, et al. Perturbed reward processing in pediatric bipolar disorder: an antisaccade study. JOURNAL OF PSYCHOPHARMACOLOGY. 2010;24(12):1779–84.
IEEE
[1]
S. Müller et al., “Perturbed reward processing in pediatric bipolar disorder: an antisaccade study,” JOURNAL OF PSYCHOPHARMACOLOGY, vol. 24, no. 12, pp. 1779–1784, 2010.
@article{1929247,
  abstract     = {{Pediatric bipolar disorder is a severe and impairing illness. Characterizing the impact of pediatric bipolar disorder on cognitive function might aid in understanding the phenomenology of the disorder. While previous studies of pediatric bipolar disorder have reported deficits in cognitive control and reward behavior, little is understood about how affective processes influence behavioral control. Relative to prior studies using manual-response paradigms, eye movement tasks provide a more precise assessment of reward sensitivity and cognitive and motor control. The current study compares 20 youths with bipolar disorder (mean age = 13.9 years +/- 2.22) and 23 healthy subjects (mean age = 13.8 years +/- 2.49) on a mixed pro-antisaccade task with monetary incentives. On both types of saccades, participants were presented with three types of incentives: those where subjects can win money, lose money, or neither win nor lose money. Impaired reward processing was found in youths with bipolar disorder relative to controls, particularly on antisaccades. This difference was reflected in lower error rates during incentive trials in the control but not in the bipolar disorder group. By comparison, no group differences were found on prosaccade trials. The results provide further evidence for deficits in cognitive and reward processing in bipolar disorder.}},
  author       = {{Müller, Sven and Ng, Pamela and Temple, Veronika and Hardin, Michael and Pine, Daniel and Leibenluft, Ellen and Ernst, Monique}},
  issn         = {{0269-8811}},
  journal      = {{JOURNAL OF PSYCHOPHARMACOLOGY}},
  keywords     = {{DEFICIT HYPERACTIVITY DISORDER,SACCADIC EYE-MOVEMENTS,SEVERE MOOD DYSREGULATION,COGNITIVE CONTROL,DEPRESSED ADOLESCENTS,VOLUNTARY CONTROL,SCHIZOPHRENIA,TASK,PSYCHOPATHOLOGY,CONTINGENCIES,bipolar disorder,reward,antisaccade,cognitive control,emotion,ADHD}},
  language     = {{eng}},
  number       = {{12}},
  pages        = {{1779--1784}},
  title        = {{Perturbed reward processing in pediatric bipolar disorder: an antisaccade study}},
  url          = {{http://doi.org/10.1177/0269881109353462}},
  volume       = {{24}},
  year         = {{2010}},
}
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