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Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein

René Devos, Joël Vandekerckhove UGent, Antonius Rolink, Geert Plaetinck, José Van der Heyden, Walter Fiers UGent and Jan Tavernier UGent (1991) EUROPEAN JOURNAL OF IMMUNOLOGY. 21(5). p.1315-1317
abstract
A polypeptide chain for the mouse interleukin 5 receptor (IL5R) was purified from detergent-lysed B13 cells, a mouse IL5-dependent pre-B cell line. Purification was by a single immunoaffinity chromatographic step using an anti-mouse IL5R monoclonal antibody, R52. Internal amino acid sequence was obtained from four trypsin-generated peptides. All peptides were found to be present in the published amino acid sequence of a mouse IL3R and the mouse IL3R-like protein deduced from the cDNA. This indicates that the mouse IL5R and the mouse IL3R have a homologous polypeptide in common and suggests that the specificity of these lymphokine receptors is mainly generated by association with another ligand-specific polypeptide chain.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (letterNote)
publication status
published
subject
keyword
CELLS, MEMBER, CLONING, IDENTIFICATION, GENE FAMILY, EXPRESSION, IL-5
journal title
EUROPEAN JOURNAL OF IMMUNOLOGY
Eur. J. Immunol.
volume
21
issue
5
pages
1315 - 1317
Web of Science type
Note
ISSN
0014-2980
DOI
10.1002/eji.1830210533
language
English
UGent publication?
yes
classification
A1
id
1925360
handle
http://hdl.handle.net/1854/LU-1925360
date created
2011-10-13 11:16:04
date last changed
2011-11-17 16:21:15
@article{1925360,
  abstract     = {A polypeptide chain for the mouse interleukin 5 receptor (IL5R) was purified from detergent-lysed B13 cells, a mouse IL5-dependent pre-B cell line. Purification was by a single immunoaffinity chromatographic step using an anti-mouse IL5R monoclonal antibody, R52. Internal amino acid sequence was obtained from four trypsin-generated peptides. All peptides were found to be present in the published amino acid sequence of a mouse IL3R and the mouse IL3R-like protein deduced from the cDNA. This indicates that the mouse IL5R and the mouse IL3R have a homologous polypeptide in common and suggests that the specificity of these lymphokine receptors is mainly generated by association with another ligand-specific polypeptide chain.},
  author       = {Devos, Ren{\'e} and Vandekerckhove, Jo{\"e}l and Rolink, Antonius and Plaetinck, Geert and Van der Heyden, Jos{\'e} and Fiers, Walter and Tavernier, Jan},
  issn         = {0014-2980},
  journal      = {EUROPEAN JOURNAL OF IMMUNOLOGY},
  keyword      = {CELLS,MEMBER,CLONING,IDENTIFICATION,GENE FAMILY,EXPRESSION,IL-5},
  language     = {eng},
  number       = {5},
  pages        = {1315--1317},
  title        = {Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein},
  url          = {http://dx.doi.org/10.1002/eji.1830210533},
  volume       = {21},
  year         = {1991},
}

Chicago
Devos, René, Joël Vandekerckhove, Antonius Rolink, Geert Plaetinck, José Van der Heyden, Walter Fiers, and Jan Tavernier. 1991. “Amino Acid Sequence Analysis of a Mouse Interleukin 5 Receptor Protein Reveals Homology with a Mouse Interleukin 3 Receptor Protein.” European Journal of Immunology 21 (5): 1315–1317.
APA
Devos, René, Vandekerckhove, J., Rolink, A., Plaetinck, G., Van der Heyden, J., Fiers, W., & Tavernier, J. (1991). Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein. EUROPEAN JOURNAL OF IMMUNOLOGY, 21(5), 1315–1317.
Vancouver
1.
Devos R, Vandekerckhove J, Rolink A, Plaetinck G, Van der Heyden J, Fiers W, et al. Amino acid sequence analysis of a mouse interleukin 5 receptor protein reveals homology with a mouse interleukin 3 receptor protein. EUROPEAN JOURNAL OF IMMUNOLOGY. 1991;21(5):1315–7.
MLA
Devos, René, Joël Vandekerckhove, Antonius Rolink, et al. “Amino Acid Sequence Analysis of a Mouse Interleukin 5 Receptor Protein Reveals Homology with a Mouse Interleukin 3 Receptor Protein.” EUROPEAN JOURNAL OF IMMUNOLOGY 21.5 (1991): 1315–1317. Print.