Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α
- Author
- Carl Grunfeld, Mounzer Soued, Saleh Adi, Arthur H Moser, Walter Fiers, Charles A Dinarello and Kenneth R Feingold
- Organization
- Abstract
- Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokines. Interleukin 4 by itself did not alter hepatic lipogenesis. However, interleukin 4 inhibited the characteristic stimulation of hepatic lipogenesis that is seen with tumor necrosis factor, interleukin 1, and interleukin 6. These 3 cytokines stimulate hepatic lipogenesis by the same mechanism, increasing hepatic levels of citrate, a key allosteric activator of acetyl CoA carboxylase, the rate-limiting enzyme of fatty acid synthesis. Interleukin 4 blocks the ability of tumornecrosis factor to increase hepatic citrate. In contrast, interleukin 4 does not block the stimulation of hepatic lipogenesis by interferon-alpha, a cytokine that increases hepatic lipogenesis by a mechanism other than increasing hepatic citrate levels. These results demonstrate that interleukin 4 can inhibit the metabolic action of selected cytokines, which provides strong support for our proposal that lipogenic cytokines operate through 2 distinct mechanisms of action and can therefore be divided into 2 separate classes based on their interactions. These results also emphasize the multiple relationships between the immune response and lipid metabolism.
- Keywords
- LIPID-SYNTHESIS, SYNTHESIS INVIVO, MESSENGER-RNA, DENSITY LIPOPROTEINS, KILLER CELLS, LIPOPROTEIN-LIPASE ACTIVITY, PHASE PLASMA-PROTEINS, CELL GROWTH-FACTOR, INTACT RAT, B-CELLS
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1925329
- MLA
- Grunfeld, Carl, et al. “Interleukin 4 Inhibits Stimulation of Hepatic Lipogenesis by Tumor Necrosis Factor, Interleukin 1, and Interleukin 6 but Not by Interferon-α.” CANCER RESEARCH, vol. 51, no. 11, 1991, pp. 2803–07.
- APA
- Grunfeld, C., Soued, M., Adi, S., Moser, A. H., Fiers, W., Dinarello, C. A., & Feingold, K. R. (1991). Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α. CANCER RESEARCH, 51(11), 2803–2807.
- Chicago author-date
- Grunfeld, Carl, Mounzer Soued, Saleh Adi, Arthur H Moser, Walter Fiers, Charles A Dinarello, and Kenneth R Feingold. 1991. “Interleukin 4 Inhibits Stimulation of Hepatic Lipogenesis by Tumor Necrosis Factor, Interleukin 1, and Interleukin 6 but Not by Interferon-α.” CANCER RESEARCH 51 (11): 2803–7.
- Chicago author-date (all authors)
- Grunfeld, Carl, Mounzer Soued, Saleh Adi, Arthur H Moser, Walter Fiers, Charles A Dinarello, and Kenneth R Feingold. 1991. “Interleukin 4 Inhibits Stimulation of Hepatic Lipogenesis by Tumor Necrosis Factor, Interleukin 1, and Interleukin 6 but Not by Interferon-α.” CANCER RESEARCH 51 (11): 2803–2807.
- Vancouver
- 1.Grunfeld C, Soued M, Adi S, Moser AH, Fiers W, Dinarello CA, et al. Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α. CANCER RESEARCH. 1991;51(11):2803–7.
- IEEE
- [1]C. Grunfeld et al., “Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α,” CANCER RESEARCH, vol. 51, no. 11, pp. 2803–2807, 1991.
@article{1925329,
abstract = {{Multiple cytokines stimulate hepatic lipogenesis in rodents. We have previously shown that lipogenic cytokines can be divided into 2 classes by their mechanism of action and their synergistic interactions. We now report the effects of interleukin 4, a cytokine known to inhibit the synthesis and action of other cytokines. Interleukin 4 by itself did not alter hepatic lipogenesis. However, interleukin 4 inhibited the characteristic stimulation of hepatic lipogenesis that is seen with tumor necrosis factor, interleukin 1, and interleukin 6. These 3 cytokines stimulate hepatic lipogenesis by the same mechanism, increasing hepatic levels of citrate, a key allosteric activator of acetyl CoA carboxylase, the rate-limiting enzyme of fatty acid synthesis. Interleukin 4 blocks the ability of tumornecrosis factor to increase hepatic citrate. In contrast, interleukin 4 does not block the stimulation of hepatic lipogenesis by interferon-alpha, a cytokine that increases hepatic lipogenesis by a mechanism other than increasing hepatic citrate levels. These results demonstrate that interleukin 4 can inhibit the metabolic action of selected cytokines, which provides strong support for our proposal that lipogenic cytokines operate through 2 distinct mechanisms of action and can therefore be divided into 2 separate classes based on their interactions. These results also emphasize the multiple relationships between the immune response and lipid metabolism.}},
author = {{Grunfeld, Carl and Soued, Mounzer and Adi, Saleh and Moser, Arthur H and Fiers, Walter and Dinarello, Charles A and Feingold, Kenneth R}},
issn = {{0008-5472}},
journal = {{CANCER RESEARCH}},
keywords = {{LIPID-SYNTHESIS,SYNTHESIS INVIVO,MESSENGER-RNA,DENSITY LIPOPROTEINS,KILLER CELLS,LIPOPROTEIN-LIPASE ACTIVITY,PHASE PLASMA-PROTEINS,CELL GROWTH-FACTOR,INTACT RAT,B-CELLS}},
language = {{eng}},
number = {{11}},
pages = {{2803--2807}},
title = {{Interleukin 4 inhibits stimulation of hepatic lipogenesis by tumor necrosis factor, interleukin 1, and interleukin 6 but not by interferon-α}},
url = {{http://cancerres.aacrjournals.org/content/51/11/2803.abstract}},
volume = {{51}},
year = {{1991}},
}