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Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction

C Wu, JR De Jong, HA Gratama van Andel, F van der Have, B Vastenhouw, P Laverman, OC Boerman, Rudi Dierckx UGent and FJ Beekman (2011) PHYSICS IN MEDICINE AND BIOLOGY. 56(18). p.N183-N193
abstract
Attenuation of photon flux on trajectories between the source and pinhole apertures affects the quantitative accuracy of reconstructed single-photon emission computed tomography (SPECT) images. We propose a Chang-based non-uniform attenuation correction (NUA-CT) for small-animal SPECT/CT with focusing pinhole collimation, and compare the quantitative accuracy with uniform Chang correction based on (i) body outlines extracted from x-ray CT (UA-CT) and (ii) on hand drawn body contours on the images obtained with three integrated optical cameras (UA-BC). Measurements in phantoms and rats containing known activities of isotopes were conducted for evaluation. In (125)I, (201)Tl, (99m)Tc and (111)In phantom experiments, average relative errors comparing to the gold standards measured in a dose calibrator were reduced to 5.5%, 6.8%, 4.9% and 2.8%, respectively, with NUA-CT. In animal studies, these errors were 2.1%, 3.3%, 2.0% and 2.0%, respectively. Differences in accuracy on average between results of NUA-CT, UA-CT and UA-BC were less than 2.3% in phantom studies and 3.1% in animal studies except for (125)I (3.6% and 5.1%, respectively). All methods tested provide reasonable attenuation correction and result in high quantitative accuracy. NUA-CT shows superior accuracy except for (125)I, where other factors may have more impact on the quantitative accuracy than the selected attenuation correction.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
CT, PENETRATION, RECONSTRUCTION, SCATTER CORRECTION, HIGH-RESOLUTION, INFORMATION, SENSITIVITY, TOMOGRAPHY, IMAGES
journal title
PHYSICS IN MEDICINE AND BIOLOGY
Phys. Med. Biol.
volume
56
issue
18
pages
N183 - N193
Web of Science type
Article
Web of Science id
000294787300001
JCR category
ENGINEERING, BIOMEDICAL
JCR impact factor
2.829 (2011)
JCR rank
14/72 (2011)
JCR quartile
1 (2011)
ISSN
0031-9155
DOI
10.1088/0031-9155/56/18/N01
language
English
UGent publication?
no
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1922982
handle
http://hdl.handle.net/1854/LU-1922982
date created
2011-10-07 16:01:35
date last changed
2011-10-10 10:36:40
@article{1922982,
  abstract     = {Attenuation of photon flux on trajectories between the source and pinhole apertures affects the quantitative accuracy of reconstructed single-photon emission computed tomography (SPECT) images. We propose a Chang-based non-uniform attenuation correction (NUA-CT) for small-animal SPECT/CT with focusing pinhole collimation, and compare the quantitative accuracy with uniform Chang correction based on (i) body outlines extracted from x-ray CT (UA-CT) and (ii) on hand drawn body contours on the images obtained with three integrated optical cameras (UA-BC). Measurements in phantoms and rats containing known activities of isotopes were conducted for evaluation. In (125)I, (201)Tl, (99m)Tc and (111)In phantom experiments, average relative errors comparing to the gold standards measured in a dose calibrator were reduced to 5.5\%, 6.8\%, 4.9\% and 2.8\%, respectively, with NUA-CT. In animal studies, these errors were 2.1\%, 3.3\%, 2.0\% and 2.0\%, respectively. Differences in accuracy on average between results of NUA-CT, UA-CT and UA-BC were less than 2.3\% in phantom studies and 3.1\% in animal studies except for (125)I (3.6\% and 5.1\%, respectively). All methods tested provide reasonable attenuation correction and result in high quantitative accuracy. NUA-CT shows superior accuracy except for (125)I, where other factors may have more impact on the quantitative accuracy than the selected attenuation correction.},
  author       = {Wu, C and De Jong, JR and Gratama van Andel, HA and van der Have, F and Vastenhouw, B and Laverman, P and Boerman, OC and Dierckx, Rudi and Beekman, FJ},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  keyword      = {CT,PENETRATION,RECONSTRUCTION,SCATTER CORRECTION,HIGH-RESOLUTION,INFORMATION,SENSITIVITY,TOMOGRAPHY,IMAGES},
  language     = {eng},
  number       = {18},
  pages        = {N183--N193},
  title        = {Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction},
  url          = {http://dx.doi.org/10.1088/0031-9155/56/18/N01},
  volume       = {56},
  year         = {2011},
}

Chicago
Wu, C, JR De Jong, HA Gratama van Andel, F van der Have, B Vastenhouw, P Laverman, OC Boerman, Rudi Dierckx, and FJ Beekman. 2011. “Quantitative Multi-pinhole Small-animal SPECT: Uniform Versus Non-uniform Chang Attenuation Correction.” Physics in Medicine and Biology 56 (18): N183–N193.
APA
Wu, C., De Jong, J., Gratama van Andel, H., van der Have, F., Vastenhouw, B., Laverman, P., Boerman, O., et al. (2011). Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction. PHYSICS IN MEDICINE AND BIOLOGY, 56(18), N183–N193.
Vancouver
1.
Wu C, De Jong J, Gratama van Andel H, van der Have F, Vastenhouw B, Laverman P, et al. Quantitative multi-pinhole small-animal SPECT: uniform versus non-uniform Chang attenuation correction. PHYSICS IN MEDICINE AND BIOLOGY. 2011;56(18):N183–N193.
MLA
Wu, C, JR De Jong, HA Gratama van Andel, et al. “Quantitative Multi-pinhole Small-animal SPECT: Uniform Versus Non-uniform Chang Attenuation Correction.” PHYSICS IN MEDICINE AND BIOLOGY 56.18 (2011): N183–N193. Print.