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Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus

(1995) BRITISH JOURNAL OF PHARMACOLOGY. 114(3). p.640-647
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Abstract
1. The influence of aging on the relaxant response and the change in cyclic nucleotide content induced by vasoactive intestinal polypeptide (VIP), nitric oxide (NO), electrical field stimulation of the nonadrenergic non-cholinergic neurones and substances acting at different levels of the cyclic AMP and cyclic GMP transduction pathways was studied in longitudinal muscle strips of the rat gastric fundus. 2. The relaxant responses to VIP, sustained electrical stimulation, forskolin and 3-isobutyl-1-methylxanthine were reduced with age, while the responses to dibutyryl cyclic AMP were not. The increase in cyclic AMP content induced by sustained electrical stimulation and forskolin was lower in old rats. 3. The relaxant responses to NO and to short train electrical stimulation were similar in the three age groups. The inhibitory effect of N-G-nitro-L-arginine methyl ester on relaxations induced by short train electrical stimulation was more pronounced in old rats. The relaxant responses to sodium nitroprusside (SNP), 8-bromo-cyclic GMP and zaprinast were reduced with age. SNP induced a similar elevation of the cyclic GMP content in the three age groups. 4. These results suggest that aging differentially affects the cyclic AMP and cyclic GMP pathway for relaxation by VIP and NO in the rat gastric fundus, as the defect seems to occur at the level of the adenylate cyclase and cyclic GMP-dependent protein kinase respectively.
Keywords
SMOOTH-MUSCLE, PHOSPHODIESTERASE INHIBITORS, NITRIC-OXIDE, CYCLIC-GMP LEVELS, NONADRENERGIC NONCHOLINERGIC RELAXATION, VASOACTIVE INTESTINAL POLYPEPTIDE, CYCLIC GMP, CYCLIC AMP, NO, VIP, NANC, AGING, RAT GASTRIC FUNDUS, MEDIATED VASODILATION, PROTEIN-KINASE, AMP, STIMULATION

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Citation

Please use this url to cite or link to this publication:

Chicago
Smits, Geert JM, and Romain Lefebvre. 1995. “Influence of Age on the Signal Transduction Pathway of Non-adrenergic Non-cholinergic Neurotransmitters in the Rat Gastric Fundus.” British Journal of Pharmacology 114 (3): 640–647.
APA
Smits, G. J., & Lefebvre, R. (1995). Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus. BRITISH JOURNAL OF PHARMACOLOGY, 114(3), 640–647.
Vancouver
1.
Smits GJ, Lefebvre R. Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus. BRITISH JOURNAL OF PHARMACOLOGY. 1995;114(3):640–7.
MLA
Smits, Geert JM, and Romain Lefebvre. “Influence of Age on the Signal Transduction Pathway of Non-adrenergic Non-cholinergic Neurotransmitters in the Rat Gastric Fundus.” BRITISH JOURNAL OF PHARMACOLOGY 114.3 (1995): 640–647. Print.
@article{192185,
  abstract     = {1. The influence of aging on the relaxant response and the change in cyclic nucleotide content induced by vasoactive intestinal polypeptide (VIP), nitric oxide (NO), electrical field stimulation of the nonadrenergic non-cholinergic neurones and substances acting at different levels of the cyclic AMP and cyclic GMP transduction pathways was studied in longitudinal muscle strips of the rat gastric fundus. 
2. The relaxant responses to VIP, sustained electrical stimulation, forskolin and 3-isobutyl-1-methylxanthine were reduced with age, while the responses to dibutyryl cyclic AMP were not. The increase in cyclic AMP content induced by sustained electrical stimulation and forskolin was lower in old rats. 
3. The relaxant responses to NO and to short train electrical stimulation were similar in the three age groups. The inhibitory effect of N-G-nitro-L-arginine methyl ester on relaxations induced by short train electrical stimulation was more pronounced in old rats. The relaxant responses to sodium nitroprusside (SNP), 8-bromo-cyclic GMP and zaprinast were reduced with age. SNP induced a similar elevation of the cyclic GMP content in the three age groups. 
4. These results suggest that aging differentially affects the cyclic AMP and cyclic GMP pathway for relaxation by VIP and NO in the rat gastric fundus, as the defect seems to occur at the level of the adenylate cyclase and cyclic GMP-dependent protein kinase respectively.},
  author       = {Smits, Geert JM and Lefebvre, Romain},
  issn         = {0007-1188},
  journal      = {BRITISH JOURNAL OF PHARMACOLOGY},
  keyword      = {SMOOTH-MUSCLE,PHOSPHODIESTERASE INHIBITORS,NITRIC-OXIDE,CYCLIC-GMP LEVELS,NONADRENERGIC NONCHOLINERGIC RELAXATION,VASOACTIVE INTESTINAL POLYPEPTIDE,CYCLIC GMP,CYCLIC AMP,NO,VIP,NANC,AGING,RAT GASTRIC FUNDUS,MEDIATED VASODILATION,PROTEIN-KINASE,AMP,STIMULATION},
  language     = {eng},
  number       = {3},
  pages        = {640--647},
  title        = {Influence of age on the signal transduction pathway of non-adrenergic non-cholinergic neurotransmitters in the rat gastric fundus},
  url          = {http://dx.doi.org/10.1111/j.1476-5381.1995.tb17187.x},
  volume       = {114},
  year         = {1995},
}

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