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Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage

Olivier Vanakker UGent, Kris De Coen, Laura Costrop, Paul Coucke UGent, Piet Vanhaesebrouck and Anne De Paepe UGent (2011) JOURNAL OF PEDIATRICS. 159(2). p.347-349
abstract
A neonate who received vitamin K (VK) supplementation then developed severe late-onset bleeding with abnormal prothrombin time and activated partial thromboplastine time. The bleeding was corrected after intravenous VK. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
GLUTAMYL CARBOXYLASE, DEFICIENCY, K EPOXIDE REDUCTASE
journal title
JOURNAL OF PEDIATRICS
J. Pediatr.
volume
159
issue
2
pages
347 - 349
Web of Science type
Article
Web of Science id
000292878400034
JCR category
PEDIATRICS
JCR impact factor
4.115 (2011)
JCR rank
4/113 (2011)
JCR quartile
1 (2011)
ISSN
0022-3476
DOI
10.1016/j.jpeds.2011.04.044
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1921223
handle
http://hdl.handle.net/1854/LU-1921223
date created
2011-10-05 15:38:49
date last changed
2016-12-19 15:46:41
@article{1921223,
  abstract     = {A neonate who received vitamin K (VK) supplementation then developed severe late-onset bleeding with abnormal prothrombin time and activated partial thromboplastine time. The bleeding was corrected after intravenous VK. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.},
  author       = {Vanakker, Olivier and De Coen, Kris and Costrop, Laura and Coucke, Paul and Vanhaesebrouck, Piet and De Paepe, Anne},
  issn         = {0022-3476},
  journal      = {JOURNAL OF PEDIATRICS},
  keyword      = {GLUTAMYL CARBOXYLASE,DEFICIENCY,K EPOXIDE REDUCTASE},
  language     = {eng},
  number       = {2},
  pages        = {347--349},
  title        = {Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage},
  url          = {http://dx.doi.org/10.1016/j.jpeds.2011.04.044},
  volume       = {159},
  year         = {2011},
}

Chicago
Vanakker, Olivier, KRIS DE COEN, Laura Costrop, Paul Coucke, Piet Vanhaesebrouck, and Anne De Paepe. 2011. “Functional Polymorphism in Gamma-glutamylcarboxylase Is a Risk Factor for Severe Neonatal Hemorrhage.” Journal of Pediatrics 159 (2): 347–349.
APA
Vanakker, O., DE COEN, K., Costrop, L., Coucke, P., Vanhaesebrouck, P., & De Paepe, A. (2011). Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage. JOURNAL OF PEDIATRICS, 159(2), 347–349.
Vancouver
1.
Vanakker O, DE COEN K, Costrop L, Coucke P, Vanhaesebrouck P, De Paepe A. Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage. JOURNAL OF PEDIATRICS. 2011;159(2):347–9.
MLA
Vanakker, Olivier, KRIS DE COEN, Laura Costrop, et al. “Functional Polymorphism in Gamma-glutamylcarboxylase Is a Risk Factor for Severe Neonatal Hemorrhage.” JOURNAL OF PEDIATRICS 159.2 (2011): 347–349. Print.