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Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage

Olivier Vanakker (UGent) , Kris De Coen (UGent) , Laura Costrop (UGent) , Paul Coucke (UGent) , Piet Vanhaesebrouck (UGent) and Anne De Paepe (UGent)
(2011) JOURNAL OF PEDIATRICS. 159(2). p.347-349
Author
Organization
Abstract
A neonate who received vitamin K (VK) supplementation then developed severe late-onset bleeding with abnormal prothrombin time and activated partial thromboplastine time. The bleeding was corrected after intravenous VK. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.
Keywords
GLUTAMYL CARBOXYLASE, DEFICIENCY, K EPOXIDE REDUCTASE

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Citation

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Chicago
Vanakker, Olivier, Kris De Coen, Laura Costrop, Paul Coucke, Piet Vanhaesebrouck, and Anne De Paepe. 2011. “Functional Polymorphism in Gamma-glutamylcarboxylase Is a Risk Factor for Severe Neonatal Hemorrhage.” Journal of Pediatrics 159 (2): 347–349.
APA
Vanakker, O., De Coen, K., Costrop, L., Coucke, P., Vanhaesebrouck, P., & De Paepe, A. (2011). Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage. JOURNAL OF PEDIATRICS, 159(2), 347–349.
Vancouver
1.
Vanakker O, De Coen K, Costrop L, Coucke P, Vanhaesebrouck P, De Paepe A. Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage. JOURNAL OF PEDIATRICS. 2011;159(2):347–9.
MLA
Vanakker, Olivier, Kris De Coen, Laura Costrop, et al. “Functional Polymorphism in Gamma-glutamylcarboxylase Is a Risk Factor for Severe Neonatal Hemorrhage.” JOURNAL OF PEDIATRICS 159.2 (2011): 347–349. Print.
@article{1921223,
  abstract     = {A neonate who received vitamin K (VK) supplementation then developed severe late-onset bleeding with abnormal prothrombin time and activated partial thromboplastine time. The bleeding was corrected after intravenous VK. Molecular analysis of the gamma-glutamylcarboxylase gene revealed a heterozygous single nucleotide polymorphism, which decreases carboxylase activity and induces VK-dependent coagulation deficiency.},
  author       = {Vanakker, Olivier and De Coen, Kris and Costrop, Laura and Coucke, Paul and Vanhaesebrouck, Piet and De Paepe, Anne},
  issn         = {0022-3476},
  journal      = {JOURNAL OF PEDIATRICS},
  keyword      = {GLUTAMYL CARBOXYLASE,DEFICIENCY,K EPOXIDE REDUCTASE},
  language     = {eng},
  number       = {2},
  pages        = {347--349},
  title        = {Functional polymorphism in gamma-glutamylcarboxylase is a risk factor for severe neonatal hemorrhage},
  url          = {http://dx.doi.org/10.1016/j.jpeds.2011.04.044},
  volume       = {159},
  year         = {2011},
}

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