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Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study

(1997) DIABETOLOGIA. 40(6). p.698-705
Author
Organization
Abstract
The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 European countries: the EURODIAB IDDM Complications study. The anticipated significant relationships between both plasma fibrinogen and plasma von Willebrand factor concentrations and age and glycaemic control, and between fibrinogen and body mass index, were noted. Fibrinogen, adjusted for age and glycated haemoglobin concentration, was also related to smoking habits and was higher in the quartiles with highest systolic and diastolic blood pressures. There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. An inverse relationship between fibrinogen and high density lipoprotein cholesterol was also apparent in males. A prominent feature was a positive relationship between both fibrinogen and von Willebrand factor and albumin excretion rate (p < 0.001 and p < 0.003 respectively) in those with retinopathy but not in these without this complication. In view of previous observations on blood pressure and albuminuria in these subjects the findings are consistent with the hypothesis that microalbuminuria and increased plasma von Willebrand factor are due to endothelial cell perturbation in response to mildly raised blood pressure in subjects with retinopathy. Fibrinogen may also contribute to microvascular disease and its relationships to lipid vascular risk factors suggest a possible pathogenic role in arterial disease in diabetes.
Keywords
VONWILLEBRAND-FACTOR, DEPENDENT DIABETES-MELLITUS, CORONARY HEART-DISEASE, PLASMA-FIBRINOGEN, MICROALBUMINURIA, ENDOTHELIAL DYSFUNCTION, NEPHROPATHY, RETINOPATHY, fibrinogen, NEUROPATHY, VARIABLES, von Willebrand factor, albuminuria, vascular disease, insulin-dependent diabetes mellitus

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Chicago
Greaves, M, RG Malia, K Goodfellow, M Mattock, LK Stevens, JM Stephenson, JH Fuller, et al. 1997. “Fibrinogen and Von Willebrand Factor in IDDM: Relationships to Lipid Vascular Risk Factors, Blood Pressure, Glycaemic Control and Urinary Albumin Excretion Rate: The EURODIAB IDDM Complications Study.” Diabetologia 40 (6): 698–705.
APA
Greaves, M., Malia, R., Goodfellow, K., Mattock, M., Stevens, L., Stephenson, J., Fuller, J., et al. (1997). Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study. DIABETOLOGIA, 40(6), 698–705.
Vancouver
1.
Greaves M, Malia R, Goodfellow K, Mattock M, Stevens L, Stephenson J, et al. Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study. DIABETOLOGIA. 1997;40(6):698–705.
MLA
Greaves, M, RG Malia, K Goodfellow, et al. “Fibrinogen and Von Willebrand Factor in IDDM: Relationships to Lipid Vascular Risk Factors, Blood Pressure, Glycaemic Control and Urinary Albumin Excretion Rate: The EURODIAB IDDM Complications Study.” DIABETOLOGIA 40.6 (1997): 698–705. Print.
@article{1918105,
  abstract     = {The interrelationships between fibrinogen, von Willebrand factor, a marker of vascular endothelial cell damage, and serum lipids were explored in well-characterised subjects with insulin-dependent diabetes mellitus. The 2091 subjects were enrolled into a cross-sectional, clinic-based study of complications, from 16 European countries: the EURODIAB IDDM Complications study. The anticipated significant relationships between both plasma fibrinogen and plasma von Willebrand factor concentrations and age and glycaemic control, and between fibrinogen and body mass index, were noted. Fibrinogen, adjusted for age and glycated haemoglobin concentration, was also related to smoking habits and was higher in the quartiles with highest systolic and diastolic blood pressures. There was a clustering of vascular risk factors, with a positive relationship between plasma fibrinogen and serum triglyceride concentrations in both genders and between fibrinogen and total cholesterol in males. An inverse relationship between fibrinogen and high density lipoprotein cholesterol was also apparent in males. A prominent feature was a positive relationship between both fibrinogen and von Willebrand factor and albumin excretion rate (p {\textlangle} 0.001 and p {\textlangle} 0.003 respectively) in those with retinopathy but not in these without this complication. In view of previous observations on blood pressure and albuminuria in these subjects the findings are consistent with the hypothesis that microalbuminuria and increased plasma von Willebrand factor are due to endothelial cell perturbation in response to mildly raised blood pressure in subjects with retinopathy. Fibrinogen may also contribute to microvascular disease and its relationships to lipid vascular risk factors suggest a possible pathogenic role in arterial disease in diabetes.},
  author       = {Greaves, M and Malia, RG and Goodfellow, K and Mattock, M and Stevens, LK and Stephenson, JM and Fuller, JH and Karamanos, B and Tountas, C and Kofinis, A and Petrou, K and Katsilambros, N and Giorgino, R and Cignarelli, M and DeCicco, ML and Ramunni, I and IonescuTirgoviste, C and Iosif, CM and Pitei, D and Buligescu, S and Tamas, G and Kerenyi, Z and Ahmed, AM and Toth, J and Kempler, P and Muntoni, S and Songini, M and Stabilini, M and Fossarello, M and Pintus, S and Ferriss, JB and Cronin, CC and Whyte, AE and Cleary, PE and Toeller, M and Klischan, A and Forst, T and Gries, FA and Rottiers, Raoul and Priem, H and Ebeling, P and Sinisalo, M and Koivisto, VA and IdziorWalus, B and Solnica, B and SzopinskaCiba, L and Solnica, K and Krans, HMJ and Lemkes, HHPJ and Jansen, JJ and Brachter, J and NunesCorrea, J and Boavida, J and Michel, G and Wirion, R and Boulton, AJM and Ashe, H and Fernando, DJS and Pozza, G and Slaviero, G and Comi, G and Fattor, B and Bandello, F and Janka, HU and Nuber, A and Mehnert, H and BenSoussan, D and Fallas, MC and Fallas, P and Jepson, E and McHardyYoung, S and Betteridge, DJ and Milne, M and Crepaldi, G and Nosadini, R and Segato, T and Midena, E and Cipollina, MR and Fedele, D and Cathelineau, G and Cathelineau, BV and Jellal, M and Grodner, N and Feiss, PG and Santeusanio, F and Rosi, G and Ventura, MRM and Cagini, C and Marino, C and Navalesi, R and Penno, G and Miccoli, R and Nannipieri, M and Manfredi, S and Ghirlanda, G and Cotroneo, P and Manto, A and Teodonio, C and Minnella, A and Ward, JD and Tesfaye, S and Mody, C and Rudd, C and Molinatti, GM and Vitelli, F and Porta, M and Pagano, GF and Perin, PC and Estivi, P and Sivieri, R and Carta, Q and Petraroli, G and Papazoglou, N and Manes, G and Triantaphyllou, G and Ioannides, A and Skazagar, G and Kontogiannis, I and Muggeo, M and Cacciatori, V and Bellavere, F and Galante, P and Gemma, ML and Irsigler, K and Abrahamian, H and Gurdet, C and Hornlein, B and Willinger, C and Walford, S and Wardle, EV and Hughes, S and Roglic, G and Resman, Z and Metelko, Z and Skrabalo, Z and Keen, H and Navelesi, R and Sjolie, AK and Viberti, GC and Ward, J and Partridge, T and John, WG and Collins, A and Dredge, A and Sharp, R and Kohner, E and Aldington, S and Cockley, S},
  issn         = {0012-186X},
  journal      = {DIABETOLOGIA},
  keyword      = {VONWILLEBRAND-FACTOR,DEPENDENT DIABETES-MELLITUS,CORONARY HEART-DISEASE,PLASMA-FIBRINOGEN,MICROALBUMINURIA,ENDOTHELIAL DYSFUNCTION,NEPHROPATHY,RETINOPATHY,fibrinogen,NEUROPATHY,VARIABLES,von Willebrand factor,albuminuria,vascular disease,insulin-dependent diabetes mellitus},
  language     = {eng},
  number       = {6},
  pages        = {698--705},
  title        = {Fibrinogen and von Willebrand factor in IDDM: relationships to lipid vascular risk factors, blood pressure, glycaemic control and urinary albumin excretion rate: the EURODIAB IDDM complications study},
  url          = {http://dx.doi.org/10.1007/s001250050736},
  volume       = {40},
  year         = {1997},
}

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