31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients
- Author
- Harmen Reyngoudt (UGent) , Koen Paemeleire (UGent) , Benedicte Descamps (UGent) , Yves De Deene (UGent) and Eric Achten (UGent)
- Organization
- Abstract
- Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla. Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls. Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.
- Keywords
- MAGNETIC-RESONANCE-SPECTROSCOPY, phantom replacement technique, SKELETAL-MUSCLE BIOENERGETICS, FAMILIAL HEMIPLEGIC MIGRAINE, RANDOMIZED CONTROLLED-TRIAL, TENSION-TYPE HEADACHE, LOW BRAIN MAGNESIUM, MITOCHONDRIAL-DNA, CLUSTER HEADACHE, OXIDATIVE-METABOLISM, MR-SPECTROSCOPY, (31)P-MRS, creatine kinase reaction, migraine without aura, mitochondria
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1917798
- MLA
- Reyngoudt, Harmen, et al. “31P-MRS Demonstrates a Reduction in High-Energy Phosphates in the Occipital Lobe of Migraine without Aura Patients.” CEPHALALGIA, vol. 31, no. 12, 2011, pp. 1243–53, doi:10.1177/0333102410394675.
- APA
- Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y., & Achten, E. (2011). 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA, 31(12), 1243–1253. https://doi.org/10.1177/0333102410394675
- Chicago author-date
- Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2011. “31P-MRS Demonstrates a Reduction in High-Energy Phosphates in the Occipital Lobe of Migraine without Aura Patients.” CEPHALALGIA 31 (12): 1243–53. https://doi.org/10.1177/0333102410394675.
- Chicago author-date (all authors)
- Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2011. “31P-MRS Demonstrates a Reduction in High-Energy Phosphates in the Occipital Lobe of Migraine without Aura Patients.” CEPHALALGIA 31 (12): 1243–1253. doi:10.1177/0333102410394675.
- Vancouver
- 1.Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E. 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA. 2011;31(12):1243–53.
- IEEE
- [1]H. Reyngoudt, K. Paemeleire, B. Descamps, Y. De Deene, and E. Achten, “31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients,” CEPHALALGIA, vol. 31, no. 12, pp. 1243–1253, 2011.
@article{1917798,
abstract = {{Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla.
Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls.
Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls.
Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.}},
author = {{Reyngoudt, Harmen and Paemeleire, Koen and Descamps, Benedicte and De Deene, Yves and Achten, Eric}},
issn = {{0333-1024}},
journal = {{CEPHALALGIA}},
keywords = {{MAGNETIC-RESONANCE-SPECTROSCOPY,phantom replacement technique,SKELETAL-MUSCLE BIOENERGETICS,FAMILIAL HEMIPLEGIC MIGRAINE,RANDOMIZED CONTROLLED-TRIAL,TENSION-TYPE HEADACHE,LOW BRAIN MAGNESIUM,MITOCHONDRIAL-DNA,CLUSTER HEADACHE,OXIDATIVE-METABOLISM,MR-SPECTROSCOPY,(31)P-MRS,creatine kinase reaction,migraine without aura,mitochondria}},
language = {{eng}},
number = {{12}},
pages = {{1243--1253}},
title = {{31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients}},
url = {{http://doi.org/10.1177/0333102410394675}},
volume = {{31}},
year = {{2011}},
}
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