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31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients

Harmen Reyngoudt UGent, Koen Paemeleire UGent, Benedicte Descamps UGent, Yves De Deene UGent and Eric Achten UGent (2011) CEPHALALGIA. 31(12). p.1243-1253
abstract
Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla. Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls. Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.
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author
organization
alternative title
(31)P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients
year
type
journalArticle (original)
publication status
published
subject
keyword
MAGNETIC-RESONANCE-SPECTROSCOPY, phantom replacement technique, SKELETAL-MUSCLE BIOENERGETICS, FAMILIAL HEMIPLEGIC MIGRAINE, RANDOMIZED CONTROLLED-TRIAL, TENSION-TYPE HEADACHE, LOW BRAIN MAGNESIUM, MITOCHONDRIAL-DNA, CLUSTER HEADACHE, OXIDATIVE-METABOLISM, MR-SPECTROSCOPY, (31)P-MRS, creatine kinase reaction, migraine without aura, mitochondria
journal title
CEPHALALGIA
Cephalalgia
volume
31
issue
12
pages
1243 - 1253
Web of Science type
Article
Web of Science id
000294907600001
JCR category
CLINICAL NEUROLOGY
JCR impact factor
3.43 (2011)
JCR rank
44/190 (2011)
JCR quartile
1 (2011)
ISSN
0333-1024
DOI
10.1177/0333102410394675
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1917798
handle
http://hdl.handle.net/1854/LU-1917798
date created
2011-09-29 14:39:19
date last changed
2012-10-01 00:30:02
@article{1917798,
  abstract     = {Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla.
Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls.
Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls.
Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.},
  author       = {Reyngoudt, Harmen and Paemeleire, Koen and Descamps, Benedicte and De Deene, Yves and Achten, Eric},
  issn         = {0333-1024},
  journal      = {CEPHALALGIA},
  keyword      = {MAGNETIC-RESONANCE-SPECTROSCOPY,phantom replacement technique,SKELETAL-MUSCLE BIOENERGETICS,FAMILIAL HEMIPLEGIC MIGRAINE,RANDOMIZED CONTROLLED-TRIAL,TENSION-TYPE HEADACHE,LOW BRAIN MAGNESIUM,MITOCHONDRIAL-DNA,CLUSTER HEADACHE,OXIDATIVE-METABOLISM,MR-SPECTROSCOPY,(31)P-MRS,creatine kinase reaction,migraine without aura,mitochondria},
  language     = {eng},
  number       = {12},
  pages        = {1243--1253},
  title        = {31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients},
  url          = {http://dx.doi.org/10.1177/0333102410394675},
  volume       = {31},
  year         = {2011},
}

Chicago
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2011. “31P-MRS Demonstrates a Reduction in High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients.” Cephalalgia 31 (12): 1243–1253.
APA
Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y., & Achten, E. (2011). 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA, 31(12), 1243–1253.
Vancouver
1.
Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E. 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA. 2011;31(12):1243–53.
MLA
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, et al. “31P-MRS Demonstrates a Reduction in High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients.” CEPHALALGIA 31.12 (2011): 1243–1253. Print.