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31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients

Harmen Reyngoudt (UGent) , Koen Paemeleire (UGent) , Benedicte Descamps (UGent) , Yves De Deene (UGent) and Eric Achten (UGent)
(2011) CEPHALALGIA. 31(12). p.1243-1253
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Organization
Abstract
Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla. Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls. Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls. Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.
Keywords
MAGNETIC-RESONANCE-SPECTROSCOPY, phantom replacement technique, SKELETAL-MUSCLE BIOENERGETICS, FAMILIAL HEMIPLEGIC MIGRAINE, RANDOMIZED CONTROLLED-TRIAL, TENSION-TYPE HEADACHE, LOW BRAIN MAGNESIUM, MITOCHONDRIAL-DNA, CLUSTER HEADACHE, OXIDATIVE-METABOLISM, MR-SPECTROSCOPY, (31)P-MRS, creatine kinase reaction, migraine without aura, mitochondria

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Chicago
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, Yves De Deene, and Eric Achten. 2011. “31P-MRS Demonstrates a Reduction in High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients.” Cephalalgia 31 (12): 1243–1253.
APA
Reyngoudt, H., Paemeleire, K., Descamps, B., De Deene, Y., & Achten, E. (2011). 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA, 31(12), 1243–1253.
Vancouver
1.
Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E. 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. CEPHALALGIA. 2011;31(12):1243–53.
MLA
Reyngoudt, Harmen, Koen Paemeleire, Benedicte Descamps, et al. “31P-MRS Demonstrates a Reduction in High-energy Phosphates in the Occipital Lobe of Migraine Without Aura Patients.” CEPHALALGIA 31.12 (2011): 1243–1253. Print.
@article{1917798,
  abstract     = {Background: Differences in brain energy metabolism have been found between migraine patients and controls in previous phosphorus magnetic resonance spectroscopy ((31)P-MRS) studies, most of them emphasizing migraine with aura (MwA). The aim of this study was to verify potential changes in resting-state brain energy metabolism in patients with migraine without aura (MwoA) compared to control subjects by (31)P-MRS at 3 tesla.
Methods: Quantification was performed using the phantom replacement technique. MRS measurements were performed interictally and in the medial occipital lobe of 19 MwoA patients and 26 age-matched controls.
Results: A significantly decreased phosphocreatine concentration ([PCr]) was found as in previous studies. While adenosine triphosphate concentration ([ATP]) was considered to be constant in previously published work, this study found a significant decrease in the measured [ATP] in MwoA patients. The inorganic phosphate ([P(i)]) and magnesium ([Mg(2+)]) concentrations were not significantly different between MwoA patients and controls.
Conclusions: The altered metabolic concentrations indicate that the energy metabolism in MwoA patients is impaired, certainly in a subgroup of patients. The actual decrease in [ATP] adds further strength to the theory of the presence of a mitochondrial component in the pathophysiology of migraine.},
  author       = {Reyngoudt, Harmen and Paemeleire, Koen and Descamps, Benedicte and De Deene, Yves and Achten, Eric},
  issn         = {0333-1024},
  journal      = {CEPHALALGIA},
  keyword      = {MAGNETIC-RESONANCE-SPECTROSCOPY,phantom replacement technique,SKELETAL-MUSCLE BIOENERGETICS,FAMILIAL HEMIPLEGIC MIGRAINE,RANDOMIZED CONTROLLED-TRIAL,TENSION-TYPE HEADACHE,LOW BRAIN MAGNESIUM,MITOCHONDRIAL-DNA,CLUSTER HEADACHE,OXIDATIVE-METABOLISM,MR-SPECTROSCOPY,(31)P-MRS,creatine kinase reaction,migraine without aura,mitochondria},
  language     = {eng},
  number       = {12},
  pages        = {1243--1253},
  title        = {31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients},
  url          = {http://dx.doi.org/10.1177/0333102410394675},
  volume       = {31},
  year         = {2011},
}

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