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Breastfeeding in infancy is not associated with inflammatory status in healthy adolescents

(2011) JOURNAL OF NUTRITION. 141(3). p.411-417
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Abstract
It has been suggested that breast-feeding (BF) may be associated with a decreased risk of cardiovascular disease in adulthood. A low-grade inflammation is associated with an increased risk of cardiovascular disease, even in apparently healthy children. The objective of this study was to assess the potential modulating effect of BF on the inflammatory status of healthy adolescents. Information on BE (duration) was obtained from parental records in 484 of 1040 healthy European urban adolescents (56.4% females) that had a blood sample obtained as part of the Healthy Lifestyle in Europe by Nutrition and Adolescence study. Blood serum inflammatory markers were measured, including high sensitivity C-reactive protein, complement factors 3 and 4, ceruloplasmin, adhesion molecules (L-selectin and soluble endothelial selectin, soluble vascular cell adhesion molecule 1, and intercellular adhesion molecule 1), cytokines, TGF beta 1, and white blood cells. After univariate analysis, a propensity score, including the potential confounding factors, was computed and used to assess the association between BF and selected inflammatory markers. BE was not significantly associated with any of the selected inflammatory markers after adjustment for gender and propensity score. In our study, BE was not associated with low-grade inflammatory status in healthy adolescents, suggesting that the potential cardiovascular benefits of BF are related to other mechanisms than modulation of inflammation or might become relevant at a later age. Groups at high risk for cardiovascular disease should be a target for further research concerning the effects of BF.
Keywords
BLOOD-PRESSURE, LIFE-STYLE, PHYSICAL-ACTIVITY, CORONARY-ARTERY-DISEASE, CARDIOVASCULAR RISK-FACTORS, LOW-GRADE INFLAMMATION, C-REACTIVE PROTEIN, INTIMA-MEDIA THICKNESS, PRETERM BIRTH, YOUNG ADULTHOOD

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Chicago
Vérier, Caroline MP, Alain Duhamel, Laurent Béghin, Ligia-Esperanza Diaz, Julia Warnberg, Ascensión Marcos, Sonia Gómez-Martínez, et al. 2011. “Breastfeeding in Infancy Is Not Associated with Inflammatory Status in Healthy Adolescents.” Journal of Nutrition 141 (3): 411–417.
APA
Vérier, C. M., Duhamel, A., Béghin, L., Diaz, L.-E., Warnberg, J., Marcos, A., Gómez-Martínez, S., et al. (2011). Breastfeeding in infancy is not associated with inflammatory status in healthy adolescents. JOURNAL OF NUTRITION, 141(3), 411–417.
Vancouver
1.
Vérier CM, Duhamel A, Béghin L, Diaz L-E, Warnberg J, Marcos A, et al. Breastfeeding in infancy is not associated with inflammatory status in healthy adolescents. JOURNAL OF NUTRITION. 2011;141(3):411–7.
MLA
Vérier, Caroline MP, Alain Duhamel, Laurent Béghin, et al. “Breastfeeding in Infancy Is Not Associated with Inflammatory Status in Healthy Adolescents.” JOURNAL OF NUTRITION 141.3 (2011): 411–417. Print.
@article{1907530,
  abstract     = {It has been suggested that breast-feeding (BF) may be associated with a decreased risk of cardiovascular disease in adulthood. A low-grade inflammation is associated with an increased risk of cardiovascular disease, even in apparently healthy children. The objective of this study was to assess the potential modulating effect of BF on the inflammatory status of healthy adolescents. Information on BE (duration) was obtained from parental records in 484 of 1040 healthy European urban adolescents (56.4\% females) that had a blood sample obtained as part of the Healthy Lifestyle in Europe by Nutrition and Adolescence study. Blood serum inflammatory markers were measured, including high sensitivity C-reactive protein, complement factors 3 and 4, ceruloplasmin, adhesion molecules (L-selectin and soluble endothelial selectin, soluble vascular cell adhesion molecule 1, and intercellular adhesion molecule 1), cytokines, TGF beta 1, and white blood cells. After univariate analysis, a propensity score, including the potential confounding factors, was computed and used to assess the association between BF and selected inflammatory markers. BE was not significantly associated with any of the selected inflammatory markers after adjustment for gender and propensity score. In our study, BE was not associated with low-grade inflammatory status in healthy adolescents, suggesting that the potential cardiovascular benefits of BF are related to other mechanisms than modulation of inflammation or might become relevant at a later age. Groups at high risk for cardiovascular disease should be a target for further research concerning the effects of BF.},
  author       = {V{\'e}rier, Caroline MP and Duhamel, Alain and B{\'e}ghin, Laurent and Diaz, Ligia-Esperanza and Warnberg, Julia and Marcos, Ascensi{\'o}n and G{\'o}mez-Mart{\'i}nez, Sonia and Manios, Yannis and De Henauw, Stefaan and Sj{\"o}str{\"o}m, Michael and Moreno, Luis A and Kersting, Mathilde and Breidenassel, Christina and Moln{\'a}r, D{\'e}nes and Artero, Enrique G and Ferrari, Marika and Widhalm, Kurt and Turck, Dominique and Gottrand, Fr{\'e}d{\'e}ric},
  issn         = {0022-3166},
  journal      = {JOURNAL OF NUTRITION},
  language     = {eng},
  number       = {3},
  pages        = {411--417},
  title        = {Breastfeeding in infancy is not associated with inflammatory status in healthy adolescents},
  url          = {http://dx.doi.org/10.3945/jn.110.128249},
  volume       = {141},
  year         = {2011},
}

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