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Flexible PCL tube scaffolds by winding of micro-extruded filaments

Kim Ragaert (UGent) , Ludwig Cardon (UGent) and Joris Degrieck (UGent)
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Abstract
An important requirement for tissue engineering scaffolds is matching of the functional me-chanical properties to their natural tissue counterpart. Specifically for arteries this comprises the elastic re-sponse of the vessel wall to blood pressure. Human aorta has a low elastic modulus when compared to some FDA-approved synthetic polymer materials frequently used in tissue engineering. The current research en-deavours to expand the existing production technology of 3D plotting to winding of micro-extruded filaments in order to obtain flexible polymer tubes with continuous fibre. Tube scaffolds are manufactured by conven-tional 3D plotting and by winding. Their structure and quasi-static mechanical properties are evaluated and compared to human aorta. Winded tubes are found to be far more suitable for application as a blood vessel scaffold than their 3D plotted counterparts.
Keywords
FABRICATION, DESIGN, IN-VITRO, VASCULAR GRAFTS, ABDOMINAL AORTAS, MECHANICAL-PROPERTIES, TISSUE ENGINEERING SCAFFOLDS, BLOOD-VESSEL

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Citation

Please use this url to cite or link to this publication:

Chicago
Ragaert, Kim, Ludwig Cardon, and Joris Degrieck. 2012. “Flexible PCL Tube Scaffolds by Winding of Micro-extruded Filaments.” In Innovative Developments in Virtual and Physical Prototyping, ed. PJ Bartolo, ACS DeLemos, APO Tojeira, AMH Pereira, AJ Mateus, ALA Mendes, C DosSantos, et al., 99–103. Boca Raton, FL, USA: CRC Press.
APA
Ragaert, K., Cardon, L., & Degrieck, J. (2012). Flexible PCL tube scaffolds by winding of micro-extruded filaments. In PJ Bartolo, A. DeLemos, A. Tojeira, A. Pereira, A. Mateus, A. Mendes, C. DosSantos, et al. (Eds.), Innovative developments in virtual and physical prototyping (pp. 99–103). Presented at the 5th International conference on Advanced Research in Virtual and Rapid Prototyping (VRAP 2011), Boca Raton, FL, USA: CRC Press.
Vancouver
1.
Ragaert K, Cardon L, Degrieck J. Flexible PCL tube scaffolds by winding of micro-extruded filaments. In: Bartolo P, DeLemos A, Tojeira A, Pereira A, Mateus A, Mendes A, et al., editors. Innovative developments in virtual and physical prototyping. Boca Raton, FL, USA: CRC Press; 2012. p. 99–103.
MLA
Ragaert, Kim, Ludwig Cardon, and Joris Degrieck. “Flexible PCL Tube Scaffolds by Winding of Micro-extruded Filaments.” Innovative Developments in Virtual and Physical Prototyping. Ed. PJ Bartolo et al. Boca Raton, FL, USA: CRC Press, 2012. 99–103. Print.
@inproceedings{1906395,
  abstract     = {An important requirement for tissue engineering scaffolds is matching of the functional me-chanical properties to their natural tissue counterpart. Specifically for arteries this comprises the elastic re-sponse of the vessel wall to blood pressure. Human aorta has a low elastic modulus when compared to some FDA-approved synthetic polymer materials frequently used in tissue engineering. The current research en-deavours to expand the existing production technology of 3D plotting to winding of micro-extruded filaments in order to obtain flexible polymer tubes with continuous fibre. Tube scaffolds are manufactured by conven-tional 3D plotting and by winding. Their structure and quasi-static mechanical properties are evaluated and compared to human aorta. Winded tubes are found to be far more suitable for application as a blood vessel scaffold than their 3D plotted counterparts.},
  author       = {Ragaert, Kim and Cardon, Ludwig and Degrieck, Joris},
  booktitle    = {Innovative developments in virtual and physical prototyping},
  editor       = {Bartolo, PJ and DeLemos, ACS and Tojeira, APO and Pereira, AMH and Mateus, AJ and Mendes, ALA and DosSantos, C and Freitas, DMF and Bartolo, HM and Almeida, HD and DosReis, IM and Dias, JR and Domingos, MAN and Alves, NMF and Pereira, RFB and Patricio, TMF and Dias Ferreira, Telma Margarida},
  isbn         = {9780415684187},
  keyword      = {FABRICATION,DESIGN,IN-VITRO,VASCULAR GRAFTS,ABDOMINAL AORTAS,MECHANICAL-PROPERTIES,TISSUE ENGINEERING SCAFFOLDS,BLOOD-VESSEL},
  language     = {eng},
  location     = {Leiria , Portugal},
  pages        = {99--103},
  publisher    = {CRC Press},
  title        = {Flexible PCL tube scaffolds by winding of micro-extruded filaments},
  url          = {http://dx.doi.org/10.1201/b11341-18},
  year         = {2012},
}

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