- Author
- Riccardo Surmont (UGent) , Guido Verniest (UGent) , Mathias De Schrijver (UGent) , Jan Willem Thuring, Peter ten Holte, Frederik Deroose and Norbert De Kimpe (UGent)
- Organization
- Abstract
- Fluorinated pyrazoles bearing additional functional groups that allow further functionalization are of considerable interest as building blocks in medicinal chemistry. The developed synthetic strategy for new 3-amino-4-fluoropyrazoles consists of a monofluorination of β-methylthio- β-enaminoketones using 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2] octane bis(tetrafluoroborate) (Selectfluor) toward the corresponding monofluorinated enaminoketones, followed by condensation with different hydrazines.
- Keywords
- PYRAZOLE FORMATION, FLUORINATED TEBUFENPYRAD ANALOGS, ALPHA, HETEROCYCLES, CHEMISTRY, DITHIOACETALS, S, N-ACETALS, INHIBITORS, REAGENTS, KETONES
Downloads
-
(...).pdf
- full text
- |
- UGent only
- |
- |
- 979.25 KB
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-1904050
- MLA
- Surmont, Riccardo, et al. “Synthesis of 3-Amino-4-Fluoropyrazoles.” JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 10, 2011, pp. 4105–11, doi:10.1021/jo2000989.
- APA
- Surmont, R., Verniest, G., De Schrijver, M., Thuring, J. W., ten Holte, P., Deroose, F., & De Kimpe, N. (2011). Synthesis of 3-amino-4-fluoropyrazoles. JOURNAL OF ORGANIC CHEMISTRY, 76(10), 4105–4111. https://doi.org/10.1021/jo2000989
- Chicago author-date
- Surmont, Riccardo, Guido Verniest, Mathias De Schrijver, Jan Willem Thuring, Peter ten Holte, Frederik Deroose, and Norbert De Kimpe. 2011. “Synthesis of 3-Amino-4-Fluoropyrazoles.” JOURNAL OF ORGANIC CHEMISTRY 76 (10): 4105–11. https://doi.org/10.1021/jo2000989.
- Chicago author-date (all authors)
- Surmont, Riccardo, Guido Verniest, Mathias De Schrijver, Jan Willem Thuring, Peter ten Holte, Frederik Deroose, and Norbert De Kimpe. 2011. “Synthesis of 3-Amino-4-Fluoropyrazoles.” JOURNAL OF ORGANIC CHEMISTRY 76 (10): 4105–4111. doi:10.1021/jo2000989.
- Vancouver
- 1.Surmont R, Verniest G, De Schrijver M, Thuring JW, ten Holte P, Deroose F, et al. Synthesis of 3-amino-4-fluoropyrazoles. JOURNAL OF ORGANIC CHEMISTRY. 2011;76(10):4105–11.
- IEEE
- [1]R. Surmont et al., “Synthesis of 3-amino-4-fluoropyrazoles,” JOURNAL OF ORGANIC CHEMISTRY, vol. 76, no. 10, pp. 4105–4111, 2011.
@article{1904050,
abstract = {{Fluorinated pyrazoles bearing additional functional groups that allow further functionalization are of considerable interest as building blocks in medicinal chemistry. The developed synthetic strategy for new 3-amino-4-fluoropyrazoles consists of a monofluorination of β-methylthio- β-enaminoketones using 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2] octane bis(tetrafluoroborate) (Selectfluor) toward the corresponding monofluorinated enaminoketones, followed by condensation with different hydrazines.}},
author = {{Surmont, Riccardo and Verniest, Guido and De Schrijver, Mathias and Thuring, Jan Willem and ten Holte, Peter and Deroose, Frederik and De Kimpe, Norbert}},
issn = {{0022-3263}},
journal = {{JOURNAL OF ORGANIC CHEMISTRY}},
keywords = {{PYRAZOLE FORMATION,FLUORINATED TEBUFENPYRAD ANALOGS,ALPHA,HETEROCYCLES,CHEMISTRY,DITHIOACETALS,S,N-ACETALS,INHIBITORS,REAGENTS,KETONES}},
language = {{eng}},
number = {{10}},
pages = {{4105--4111}},
title = {{Synthesis of 3-amino-4-fluoropyrazoles}},
url = {{http://dx.doi.org/10.1021/jo2000989}},
volume = {{76}},
year = {{2011}},
}
- Altmetric
- View in Altmetric
- Web of Science
- Times cited: