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Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic cardiomyopathy?

Laure Ernande, Cyril Bergerot, Ernst Rietzschel UGent, Marc De Buyzere, Hélène Thibault, Pierre Gautier Pignonblanc, Pierre Croisille, Michel Ovize, Laure Groisne, Philippe Moulin, et al. (2011) JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. 24(11). p.1268-1275
abstract
BACKGROUND: Diastolic dysfunction is considered the first marker of diabetic cardiomyopathy. However, preclinical systolic alteration was also recently described by strain, but its association with diastolic dysfunction has never been investigated. METHODS: One hundred fourteen patients with type 2 diabetes mellitus (DM) with controlled blood pressure and without overt heart disease were prospectively enrolled and compared with 88 age-matched controls. All subjects underwent comprehensive echocardiography, including diastolic evaluation according to current recommendations and speckle-tracking imaging. The prevalence of diastolic dysfunction, the determinants of diastolic parameters, and the association between preclinical systolic and diastolic dysfunctions were studied. RESULTS: Diastolic parameters were altered in patients compared with controls, with lower E/A ratios, longer mitral deceleration and isovolumic relaxation times, and higher E/e' ratio. Diastolic dysfunction occurred in 47% of patients with DM (33% and 14% with grade I and II diastolic dysfunction, respectively) and systolic alteration (longitudinal strain ≥ -18%) in 32% of patients. Whereas longitudinal systolic strain was independently associated with DM and gender, diastolic parameters were influenced by many factors, including age, rate-pressure product, history of hypertension, and body mass index. Systolic alteration occurred in 28% of patients with DM with normal diastolic function and in 35% with diastolic dysfunction. CONCLUSIONS: Diastolic dysfunction diagnosed according to current recommendations is frequent in patients with DM but is also influenced by other factors. Systolic strain alteration may exist despite normal diastolic function, indicating that diastolic dysfunction should not be considered the first marker of a preclinical form of diabetic cardiomyopathy
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Diastolic function, Speckle-tracking imaging, Diabetes mellitus, Diabetic cardiomyopathy, LEFT-VENTRICULAR RELAXATION, SPECKLE TRACKING ECHOCARDIOGRAPHY, DOPPLER-ECHOCARDIOGRAPHY, ASYMPTOMATIC PATIENTS, NORMOTENSIVE PATIENTS, FILLING PRESSURES, HEART-FAILURE, ASSOCIATION, PREVALENCE, MASS
journal title
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
J. Am. Soc. Echocardiogr.
volume
24
issue
11
pages
1268 - 1275
Web of Science type
Article
Web of Science id
000296561800015
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
3.707 (2011)
JCR rank
30/117 (2011)
JCR quartile
2 (2011)
ISSN
0894-7317
DOI
10.1016/j.echo.2011.07.017
project
The Asklepios study
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1901960
handle
http://hdl.handle.net/1854/LU-1901960
date created
2011-09-15 21:03:56
date last changed
2016-12-19 15:41:56
@article{1901960,
  abstract     = {BACKGROUND: Diastolic dysfunction is considered the first marker of diabetic cardiomyopathy. However, preclinical systolic alteration was also recently described by strain, but its association with diastolic dysfunction has never been investigated.
METHODS: One hundred fourteen patients with type 2 diabetes mellitus (DM) with controlled blood pressure and without overt heart disease were prospectively enrolled and compared with 88 age-matched controls. All subjects underwent comprehensive echocardiography, including diastolic evaluation according to current recommendations and speckle-tracking imaging. The prevalence of diastolic dysfunction, the determinants of diastolic parameters, and the association between preclinical systolic and diastolic dysfunctions were studied.
RESULTS: Diastolic parameters were altered in patients compared with controls, with lower E/A ratios, longer mitral deceleration and isovolumic relaxation times, and higher E/e' ratio. Diastolic dysfunction occurred in 47\% of patients with DM (33\% and 14\% with grade I and II diastolic dysfunction, respectively) and systolic alteration (longitudinal strain \ensuremath{\geq} -18\%) in 32\% of patients. Whereas longitudinal systolic strain was independently associated with DM and gender, diastolic parameters were influenced by many factors, including age, rate-pressure product, history of hypertension, and body mass index. Systolic alteration occurred in 28\% of patients with DM with normal diastolic function and in 35\% with diastolic dysfunction.
CONCLUSIONS: Diastolic dysfunction diagnosed according to current recommendations is frequent in patients with DM but is also influenced by other factors. Systolic strain alteration may exist despite normal diastolic function, indicating that diastolic dysfunction should not be considered the first marker of a preclinical form of diabetic cardiomyopathy},
  author       = {Ernande, Laure and Bergerot, Cyril and Rietzschel, Ernst and De Buyzere, Marc and Thibault, H{\'e}l{\`e}ne and Pignonblanc, Pierre Gautier and Croisille, Pierre and Ovize, Michel and Groisne, Laure and Moulin, Philippe and Gillebert, Thierry and Derumeaux, Genevi{\`e}ve},
  issn         = {0894-7317},
  journal      = {JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY},
  keyword      = {Diastolic function,Speckle-tracking imaging,Diabetes mellitus,Diabetic cardiomyopathy,LEFT-VENTRICULAR RELAXATION,SPECKLE TRACKING ECHOCARDIOGRAPHY,DOPPLER-ECHOCARDIOGRAPHY,ASYMPTOMATIC PATIENTS,NORMOTENSIVE PATIENTS,FILLING PRESSURES,HEART-FAILURE,ASSOCIATION,PREVALENCE,MASS},
  language     = {eng},
  number       = {11},
  pages        = {1268--1275},
  title        = {Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic cardiomyopathy?},
  url          = {http://dx.doi.org/10.1016/j.echo.2011.07.017},
  volume       = {24},
  year         = {2011},
}

Chicago
Ernande, Laure, Cyril Bergerot, Ernst Rietzschel, MARC DE BUYZERE, Hélène Thibault, Pierre Gautier Pignonblanc, Pierre Croisille, et al. 2011. “Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus: Is It Really the First Marker of Diabetic Cardiomyopathy?” Journal of the American Society of Echocardiography 24 (11): 1268–1275.
APA
Ernande, Laure, Bergerot, C., Rietzschel, E., DE BUYZERE, M., Thibault, H., Pignonblanc, P. G., Croisille, P., et al. (2011). Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic cardiomyopathy? JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 24(11), 1268–1275.
Vancouver
1.
Ernande L, Bergerot C, Rietzschel E, DE BUYZERE M, Thibault H, Pignonblanc PG, et al. Diastolic dysfunction in patients with type 2 diabetes mellitus: is it really the first marker of diabetic cardiomyopathy? JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY. 2011;24(11):1268–75.
MLA
Ernande, Laure, Cyril Bergerot, Ernst Rietzschel, et al. “Diastolic Dysfunction in Patients with Type 2 Diabetes Mellitus: Is It Really the First Marker of Diabetic Cardiomyopathy?” JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY 24.11 (2011): 1268–1275. Print.