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Assessment of tumor vascularization in pancreatic adenocarcinoma using 128-slice perfusion computed tomography imaging

LOUKE DELRUE UGent, PETER BLANCKAERT UGent, Dokus Mertens, Ercan Cesmeli UGent, Wim Ceelen UGent and Philippe Duyck UGent (2011) JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY. 35(4). p.434-438
abstract
Objective: Computed tomography (CT) perfusion studies can provide valuable information regarding tumor vascularization. We report on a study assessing CT perfusion characteristics in the normal pancreas and in patients with pancreatic adenocarcinoma. Methods: Twenty healthy subjects and 20 patients with histologically confirmed pancreatic adenocarcinoma were included in the study after written informed consent and approval by our institutional review board. All subjects underwent perfusion CT imaging of the pancreas using 128-slice dual-source CT. The scanning sequence included 18 scans. Parametric maps of blood volume (BV), blood flow (BF), and permeability surface area product (PS) were generated and compared with density measurements. Results: In normal pancreas, no significant difference in perfusion values was observed between head, body, and tail of the pancreas. Mean organ values were 76.76 (SD, 15.6) mL/100 g/min, 15.80 (SD, 2.40) mL/100 g, and 27.74 (SD, 16.8) mL/100 g/min for BF, BV, and PS, respectively. Compared with the normal pancreas, a 60% reduction in BF and BV was observed in the tumor tissue. Perfusion values gradually increased toward the tumor rim. Necrotic tumor areas were identified in 25% of patients. No significant differences were observed when comparing normal pancreas and healthy pancreatic tissue in adenocarcinoma patients. Conclusions: The feasibility of whole-tumor perfusion imaging using 128-slice CT was demonstrated in patients with pancreatic adenocarcinoma. Perfusion CT provides additional information compared with image assessment based on density measurements (Hounsfield units) and allows noninvasive assessment of vascularization in the tumor tissue.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
adenocarcinoma, SOFTWARE QUANTITATIVE-ANALYSIS, pancreas, perfusion CT, abdominal CT, ACUTE STROKE PATIENTS, CT REFLECTS ANGIOGENESIS, IDENTICAL SOURCE DATA, BLOOD-FLOW, PROGNOSTIC-FACTORS, ENDOCRINE TUMORS, CANCER, MAPS, CARCINOMA
journal title
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
J. Comput. Assist. Tomogr.
volume
35
issue
4
pages
434 - 438
Web of Science type
Article
Web of Science id
000292773800003
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.221 (2011)
JCR rank
84/116 (2011)
JCR quartile
3 (2011)
ISSN
0363-8715
DOI
10.1097/RCT.0b013e318223f0c5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1898628
handle
http://hdl.handle.net/1854/LU-1898628
date created
2011-09-07 16:14:38
date last changed
2011-09-08 10:10:22
@article{1898628,
  abstract     = {Objective: Computed tomography (CT) perfusion studies can provide valuable information regarding tumor vascularization. We report on a study assessing CT perfusion characteristics in the normal pancreas and in patients with pancreatic adenocarcinoma. 
Methods: Twenty healthy subjects and 20 patients with histologically confirmed pancreatic adenocarcinoma were included in the study after written informed consent and approval by our institutional review board. All subjects underwent perfusion CT imaging of the pancreas using 128-slice dual-source CT. The scanning sequence included 18 scans. Parametric maps of blood volume (BV), blood flow (BF), and permeability surface area product (PS) were generated and compared with density measurements. 
Results: In normal pancreas, no significant difference in perfusion values was observed between head, body, and tail of the pancreas. Mean organ values were 76.76 (SD, 15.6) mL/100 g/min, 15.80 (SD, 2.40) mL/100 g, and 27.74 (SD, 16.8) mL/100 g/min for BF, BV, and PS, respectively. Compared with the normal pancreas, a 60\% reduction in BF and BV was observed in the tumor tissue. Perfusion values gradually increased toward the tumor rim. Necrotic tumor areas were identified in 25\% of patients. No significant differences were observed when comparing normal pancreas and healthy pancreatic tissue in adenocarcinoma patients. 
Conclusions: The feasibility of whole-tumor perfusion imaging using 128-slice CT was demonstrated in patients with pancreatic adenocarcinoma. Perfusion CT provides additional information compared with image assessment based on density measurements (Hounsfield units) and allows noninvasive assessment of vascularization in the tumor tissue.},
  author       = {DELRUE, LOUKE and BLANCKAERT, PETER and Mertens, Dokus and Cesmeli, Ercan and Ceelen, Wim and Duyck, Philippe},
  issn         = {0363-8715},
  journal      = {JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY},
  keyword      = {adenocarcinoma,SOFTWARE QUANTITATIVE-ANALYSIS,pancreas,perfusion CT,abdominal CT,ACUTE STROKE PATIENTS,CT REFLECTS ANGIOGENESIS,IDENTICAL SOURCE DATA,BLOOD-FLOW,PROGNOSTIC-FACTORS,ENDOCRINE TUMORS,CANCER,MAPS,CARCINOMA},
  language     = {eng},
  number       = {4},
  pages        = {434--438},
  title        = {Assessment of tumor vascularization in pancreatic adenocarcinoma using 128-slice perfusion computed tomography imaging},
  url          = {http://dx.doi.org/10.1097/RCT.0b013e318223f0c5},
  volume       = {35},
  year         = {2011},
}

Chicago
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, Ercan Cesmeli, Wim Ceelen, and Philippe Duyck. 2011. “Assessment of Tumor Vascularization in Pancreatic Adenocarcinoma Using 128-slice Perfusion Computed Tomography Imaging.” Journal of Computer Assisted Tomography 35 (4): 434–438.
APA
Delrue, L., BLANCKAERT, P., Mertens, D., Cesmeli, E., Ceelen, W., & Duyck, P. (2011). Assessment of tumor vascularization in pancreatic adenocarcinoma using 128-slice perfusion computed tomography imaging. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 35(4), 434–438.
Vancouver
1.
Delrue L, BLANCKAERT P, Mertens D, Cesmeli E, Ceelen W, Duyck P. Assessment of tumor vascularization in pancreatic adenocarcinoma using 128-slice perfusion computed tomography imaging. JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY. 2011;35(4):434–8.
MLA
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, et al. “Assessment of Tumor Vascularization in Pancreatic Adenocarcinoma Using 128-slice Perfusion Computed Tomography Imaging.” JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY 35.4 (2011): 434–438. Print.