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Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes

Anne Vral (UGent) , Hubert Thierens (UGent) and Leo De Ridder
(1996) INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 70(2). p.171-176
Author
Organization
Abstract
Ataxia telangiectasia (AT) is an autosomal recessive disease characterized by a progressive neuronal degeneration, immunodeficiency, cancer proneness and an extreme sensitivity to ionizing radiation. In this work, micronucleus dose-response curves for lymphocytes of normal and AT individuals, exposed in G(0) to low LET gamma-rays and high LET fast neutrons, are compared. After gamma-irradiation, the micronucleus yields for AT lymphocytes are strongly increased compared with controls. The micronucleus dose-response curve for AT cells shows a linear dependence instead of a linear-quadratic one which is found for normal cells. After neutron irradiation, the increase in micronucleus yield above controls is less pronounced than with gamma-rays and the micronucleus dose-response curves are linear, as expected. The high increase in micronucleus yield compared with controls after gamma-irradiation further suggests the application of the micronucleus assay as a diagnostic tool for ataxia telangiectasia.
Keywords
IONIZING-RADIATION, HUMAN-FIBROBLASTS, DOSE-RATE, CHROMOSOMAL-ABERRATIONS, POTENTIALLY LETHAL DAMAGE, DOUBLE-STRAND BREAKS, PERIPHERAL-BLOOD LYMPHOCYTES, IRRADIATED CULTURES, DETAILED DESCRIPTION, BIOLOGICAL DOSIMETRY

Citation

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MLA
Vral, Anne, et al. “Micronucleus Induction by 60Co γ-Rays and Fast Neutrons in Ataxia Telangiectasia Lymphocytes.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 70, no. 2, 1996, pp. 171–76, doi:10.1080/095530096145166.
APA
Vral, A., Thierens, H., & De Ridder, L. (1996). Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 70(2), 171–176. https://doi.org/10.1080/095530096145166
Chicago author-date
Vral, Anne, Hubert Thierens, and Leo De Ridder. 1996. “Micronucleus Induction by 60Co γ-Rays and Fast Neutrons in Ataxia Telangiectasia Lymphocytes.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 70 (2): 171–76. https://doi.org/10.1080/095530096145166.
Chicago author-date (all authors)
Vral, Anne, Hubert Thierens, and Leo De Ridder. 1996. “Micronucleus Induction by 60Co γ-Rays and Fast Neutrons in Ataxia Telangiectasia Lymphocytes.” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY 70 (2): 171–176. doi:10.1080/095530096145166.
Vancouver
1.
Vral A, Thierens H, De Ridder L. Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes. INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 1996;70(2):171–6.
IEEE
[1]
A. Vral, H. Thierens, and L. De Ridder, “Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes,” INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 70, no. 2, pp. 171–176, 1996.
@article{189862,
  abstract     = {{Ataxia telangiectasia (AT) is an autosomal recessive disease characterized by a progressive neuronal degeneration, immunodeficiency, cancer proneness and an extreme sensitivity to ionizing radiation. In this work, micronucleus dose-response curves for lymphocytes of normal and AT individuals, exposed in G(0) to low LET gamma-rays and high LET fast neutrons, are compared. After gamma-irradiation, the micronucleus yields for AT lymphocytes are strongly increased compared with controls. The micronucleus dose-response curve for AT cells shows a linear dependence instead of a linear-quadratic one which is found for normal cells. After neutron irradiation, the increase in micronucleus yield above controls is less pronounced than with gamma-rays and the micronucleus dose-response curves are linear, as expected. The high increase in micronucleus yield compared with controls after gamma-irradiation further suggests the application of the micronucleus assay as a diagnostic tool for ataxia telangiectasia.}},
  author       = {{Vral, Anne and Thierens, Hubert and De Ridder, Leo}},
  issn         = {{0955-3002}},
  journal      = {{INTERNATIONAL JOURNAL OF RADIATION BIOLOGY}},
  keywords     = {{IONIZING-RADIATION,HUMAN-FIBROBLASTS,DOSE-RATE,CHROMOSOMAL-ABERRATIONS,POTENTIALLY LETHAL DAMAGE,DOUBLE-STRAND BREAKS,PERIPHERAL-BLOOD LYMPHOCYTES,IRRADIATED CULTURES,DETAILED DESCRIPTION,BIOLOGICAL DOSIMETRY}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{171--176}},
  title        = {{Micronucleus induction by 60Co γ-rays and fast neutrons in ataxia telangiectasia lymphocytes}},
  url          = {{http://doi.org/10.1080/095530096145166}},
  volume       = {{70}},
  year         = {{1996}},
}
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