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Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography

Louke Delrue UGent, PETER BLANCKAERT UGent, Dokus Mertens, STEPHEN VAN MEERBEECK UGent, Wim Ceelen UGent and Philippe Duyck UGent (2012) ABDOMINAL IMAGING. 37(4). p.595-601
abstract
Purpose: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population. Materials and methods: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated. Results: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed. Conclusion: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Pancreatitis, permeability, Perfusion CT, Pancreas, Adenocarcinoma, CT, ADENOCARCINOMA, VASCULARIZATION, CANCER, TUMORS
journal title
ABDOMINAL IMAGING
Abdom. Imaging
volume
37
issue
4
pages
595 - 601
Web of Science type
Article
Web of Science id
000305911100014
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
1.905 (2012)
JCR rank
52/119 (2012)
JCR quartile
2 (2012)
ISSN
0942-8925
DOI
10.1007/s00261-011-9783-0
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1898616
handle
http://hdl.handle.net/1854/LU-1898616
date created
2011-09-07 16:06:51
date last changed
2012-09-21 14:59:18
@article{1898616,
  abstract     = {Purpose: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population.
Materials and methods: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated.
Results: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed.
Conclusion: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.},
  author       = {Delrue, Louke and BLANCKAERT, PETER and Mertens, Dokus and VAN MEERBEECK, STEPHEN and Ceelen, Wim and Duyck, Philippe},
  issn         = {0942-8925},
  journal      = {ABDOMINAL IMAGING},
  keyword      = {Pancreatitis,permeability,Perfusion CT,Pancreas,Adenocarcinoma,CT,ADENOCARCINOMA,VASCULARIZATION,CANCER,TUMORS},
  language     = {eng},
  number       = {4},
  pages        = {595--601},
  title        = {Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography},
  url          = {http://dx.doi.org/10.1007/s00261-011-9783-0},
  volume       = {37},
  year         = {2012},
}

Chicago
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, STEPHEN VAN MEERBEECK, Wim Ceelen, and Philippe Duyck. 2012. “Tissue Perfusion in Pathologies of the Pancreas: Assessment Using 128-slice Computed Tomography.” Abdominal Imaging 37 (4): 595–601.
APA
Delrue, L., BLANCKAERT, P., Mertens, D., VAN MEERBEECK, S., Ceelen, W., & Duyck, P. (2012). Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography. ABDOMINAL IMAGING, 37(4), 595–601.
Vancouver
1.
Delrue L, BLANCKAERT P, Mertens D, VAN MEERBEECK S, Ceelen W, Duyck P. Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography. ABDOMINAL IMAGING. 2012;37(4):595–601.
MLA
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, et al. “Tissue Perfusion in Pathologies of the Pancreas: Assessment Using 128-slice Computed Tomography.” ABDOMINAL IMAGING 37.4 (2012): 595–601. Print.