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Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography

Louke Delrue (UGent) , PETER BLANCKAERT (UGent) , Dokus Mertens, STEPHEN VAN MEERBEECK (UGent) , Wim Ceelen (UGent) and Philippe Duyck (UGent)
(2012) ABDOMINAL IMAGING. 37(4). p.595-601
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Abstract
Purpose: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population. Materials and methods: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated. Results: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed. Conclusion: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.
Keywords
Pancreatitis, permeability, Perfusion CT, Pancreas, Adenocarcinoma, CT, ADENOCARCINOMA, VASCULARIZATION, CANCER, TUMORS

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Chicago
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, STEPHEN VAN MEERBEECK, Wim Ceelen, and Philippe Duyck. 2012. “Tissue Perfusion in Pathologies of the Pancreas: Assessment Using 128-slice Computed Tomography.” Abdominal Imaging 37 (4): 595–601.
APA
Delrue, L., BLANCKAERT, P., Mertens, D., VAN MEERBEECK, S., Ceelen, W., & Duyck, P. (2012). Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography. ABDOMINAL IMAGING, 37(4), 595–601.
Vancouver
1.
Delrue L, BLANCKAERT P, Mertens D, VAN MEERBEECK S, Ceelen W, Duyck P. Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography. ABDOMINAL IMAGING. 2012;37(4):595–601.
MLA
Delrue, Louke, PETER BLANCKAERT, Dokus Mertens, et al. “Tissue Perfusion in Pathologies of the Pancreas: Assessment Using 128-slice Computed Tomography.” ABDOMINAL IMAGING 37.4 (2012): 595–601. Print.
@article{1898616,
  abstract     = {Purpose: Perfusion CT can provide information regarding blood perfusion and permeability in (tumor) tissues in a non-invasive manner. In this study, values of CT perfusion parameters in several pancreas pathologies were determined and compared to a control population.
Materials and methods: Dynamic 128-slice perfusion CT was performed in patients admitted to the radiology department between June 2010 and March 2011. Included pathologies were pancreatic adenocarcinoma, acute and chronic pancreatitis, neuroendocrine tumors, and (pseudo)cystic lesions. Parametric mappings of blood flow, blood volume, and permeability surface area product were generated.
Results: Blood flow and blood volume were significantly lower in acute and chronic pancreatitis compared to the control group. In the center of adenocarcinoma tumors, low blood flow and blood volume was observed, gradually increasing toward the tumor rim; perfusion values in pancreatic parenchyma adjacent to the tumor were not significantly different from the control population. In neuroendocrine tumors, significantly increased perfusion values were observed.
Conclusion: Compared to the control population, significant decreases in perfusion values were observed in all pancreatic pathologies under study, except in neuroendocrine tumors. Perfusion CT values can be used as an additional parameter to differentiate pancreatic pathologies.},
  author       = {Delrue, Louke and BLANCKAERT, PETER and Mertens, Dokus and VAN MEERBEECK, STEPHEN and Ceelen, Wim and Duyck, Philippe},
  issn         = {0942-8925},
  journal      = {ABDOMINAL IMAGING},
  language     = {eng},
  number       = {4},
  pages        = {595--601},
  title        = {Tissue perfusion in pathologies of the pancreas: assessment using 128-slice computed tomography},
  url          = {http://dx.doi.org/10.1007/s00261-011-9783-0},
  volume       = {37},
  year         = {2012},
}

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