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Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis

Steffen Vanneste UGent, Frederik Coppens UGent, EunKyoung Lee, Tyler J Donner, Zidian Xie, Gert Van Isterdael UGent, Stijn Dhondt UGent, Freya De Winter UGent, Bert De Rybel UGent and Marnik Vuylsteke UGent, et al. (2011) EMBO JOURNAL. 30(16). p.3430-3441
abstract
In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2; 3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
STOMATAL DEVELOPMENT, MITOTIC CYCLINS, A-TYPE CYCLIN, CELL-CYCLE REGULATION, LATERAL ROOT INITIATION, transcriptional repression, proliferation, G2-to-M, differentiation, A2-type cyclins, DIVISION, THALIANA, DIFFERENTIATION, GENE-EXPRESSION, DEPENDENT KINASES
journal title
EMBO JOURNAL
Embo J.
volume
30
issue
16
pages
3430 - 3441
Web of Science type
Article
Web of Science id
000293971300018
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
9.205 (2011)
JCR rank
21/286 (2011)
JCR quartile
1 (2011)
ISSN
0261-4189
DOI
10.1038/emboj.2011.240
project
Biotechnology for a sustainable economy (Bio-Economy)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1896799
handle
http://hdl.handle.net/1854/LU-1896799
date created
2011-09-02 10:05:26
date last changed
2013-02-27 13:06:45
@article{1896799,
  abstract     = {In multicellular organisms, morphogenesis relies on a strict coordination in time and space of cell proliferation and differentiation. In contrast to animals, plant development displays continuous organ formation and adaptive growth responses during their lifespan relying on a tight coordination of cell proliferation. How developmental signals interact with the plant cell-cycle machinery is largely unknown. Here, we characterize plant A2-type cyclins, a small gene family of mitotic cyclins, and show how they contribute to the fine-tuning of local proliferation during plant development. Moreover, the timely repression of CYCA2; 3 expression in newly formed guard cells is shown to require the stomatal transcription factors FOUR LIPS/MYB124 and MYB88, providing a direct link between developmental programming and cell-cycle exit in plants. Thus, transcriptional downregulation of CYCA2s represents a critical mechanism to coordinate proliferation during plant development.},
  author       = {Vanneste, Steffen and Coppens, Frederik and Lee, EunKyoung and Donner, Tyler J and Xie, Zidian and Van Isterdael, Gert and Dhondt, Stijn and De Winter, Freya and De Rybel, Bert and Vuylsteke, Marnik and De Veylder, Lieven and Friml, Jiri and Inz{\'e}, Dirk and Grotewold, Erich and Scarpella, Enrico and Sack, Fred and Beemster, Gerrit and Beeckman, Tom},
  issn         = {0261-4189},
  journal      = {EMBO JOURNAL},
  keyword      = {STOMATAL DEVELOPMENT,MITOTIC CYCLINS,A-TYPE CYCLIN,CELL-CYCLE REGULATION,LATERAL ROOT INITIATION,transcriptional repression,proliferation,G2-to-M,differentiation,A2-type cyclins,DIVISION,THALIANA,DIFFERENTIATION,GENE-EXPRESSION,DEPENDENT KINASES},
  language     = {eng},
  number       = {16},
  pages        = {3430--3441},
  title        = {Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis},
  url          = {http://dx.doi.org/10.1038/emboj.2011.240},
  volume       = {30},
  year         = {2011},
}

Chicago
Vanneste, Steffen, Frederik Coppens, EunKyoung Lee, Tyler J Donner, Zidian Xie, Gert Van Isterdael, Stijn Dhondt, et al. 2011. “Developmental Regulation of CYCA2s Contributes to Tissue-specific Proliferation in Arabidopsis.” Embo Journal 30 (16): 3430–3441.
APA
Vanneste, Steffen, Coppens, F., Lee, E., Donner, T. J., Xie, Z., Van Isterdael, G., Dhondt, S., et al. (2011). Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis. EMBO JOURNAL, 30(16), 3430–3441.
Vancouver
1.
Vanneste S, Coppens F, Lee E, Donner TJ, Xie Z, Van Isterdael G, et al. Developmental regulation of CYCA2s contributes to tissue-specific proliferation in Arabidopsis. EMBO JOURNAL. 2011;30(16):3430–41.
MLA
Vanneste, Steffen, Frederik Coppens, EunKyoung Lee, et al. “Developmental Regulation of CYCA2s Contributes to Tissue-specific Proliferation in Arabidopsis.” EMBO JOURNAL 30.16 (2011): 3430–3441. Print.