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The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands

Ruth Krebs UGent, Nico Böhler UGent, Kenneth C Roberts, Allen W Song and Marty G Woldorff (2012) CEREBRAL CORTEX. 22(3). p.607-615
abstract
Reward has been shown to promote human performance in multiple task domains. However, an important debate has developed about the uniqueness of reward-related neural signatures associated with such facilitation, as similar neural patterns can be triggered by increased attentional focus independent of reward. Here, we used functional magnetic resonance imaging to directly investigate the neural commonalities and interactions between the anticipation of both reward and task difficulty, by independently manipulating these factors in a cued-attention paradigm. In preparation for the target stimulus, both factors increased activity within the midbrain, dorsal striatum, and fronto-parietal areas, while inducing deactivations in default-mode regions. Additionally, reward engaged the ventral striatum, posterior cingulate, and occipital cortex, while difficulty engaged medial and dorsolateral frontal regions. Importantly, a network comprising the midbrain, caudate nucleus, thalamus, and anterior midcingulate cortex exhibited an interaction between reward and difficulty, presumably reflecting additional resource recruitment for demanding tasks with profitable outcome. This notion was consistent with a negative correlation between cue-related midbrain activity and difficulty-induced performance detriments in reward-predictive trials. Together, the data demonstrate that expected value and attentional demands are integrated in cortico-striatal-thalamic circuits in coordination with the dopaminergic midbrain to flexibly modulate resource allocation for an effective pursuit of behavioral goals.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
attention, fMRI, midbrain, reward, task demands, NUCLEUS-ACCUMBENS DOPAMINE, HUMAN VISUAL-CORTEX, EVENT-RELATED FMRI, COGNITIVE CONTROL, HUMAN BRAIN, DECISION-MAKING, MONETARY REWARD, BASAL GANGLIA, ACTIVATION, NETWORK
journal title
CEREBRAL CORTEX
Cereb. Cortex
volume
22
issue
3
pages
607 - 615
Web of Science type
Article
Web of Science id
000300495800010
JCR category
NEUROSCIENCES
JCR impact factor
6.828 (2012)
JCR rank
24/251 (2012)
JCR quartile
1 (2012)
ISSN
1047-3211
DOI
10.1093/cercor/bhr134
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1896006
handle
http://hdl.handle.net/1854/LU-1896006
date created
2011-08-31 16:37:36
date last changed
2015-06-17 09:50:01
@article{1896006,
  abstract     = {Reward has been shown to promote human performance in multiple task domains. However, an important debate has developed about the uniqueness of reward-related neural signatures associated with such facilitation, as similar neural patterns can be triggered by increased attentional focus independent of reward. Here, we used functional magnetic resonance imaging to directly investigate the neural commonalities and interactions between the anticipation of both reward and task difficulty, by independently manipulating these factors in a cued-attention paradigm. In preparation for the target stimulus, both factors increased activity within the midbrain, dorsal striatum, and fronto-parietal areas, while inducing deactivations in default-mode regions. Additionally, reward engaged the ventral striatum, posterior cingulate, and occipital cortex, while difficulty engaged medial and dorsolateral frontal regions. Importantly, a network comprising the midbrain, caudate nucleus, thalamus, and anterior midcingulate cortex exhibited an interaction between reward and difficulty, presumably reflecting additional resource recruitment for demanding tasks with profitable outcome. This notion was consistent with a negative correlation between cue-related midbrain activity and difficulty-induced performance detriments in reward-predictive trials. Together, the data demonstrate that expected value and attentional demands are integrated in cortico-striatal-thalamic circuits in coordination with the dopaminergic midbrain to flexibly modulate resource allocation for an effective pursuit of behavioral goals.},
  author       = {Krebs, Ruth and B{\"o}hler, Nico and Roberts, Kenneth C and Song, Allen W and Woldorff, Marty G},
  issn         = {1047-3211},
  journal      = {CEREBRAL CORTEX},
  keyword      = {attention,fMRI,midbrain,reward,task demands,NUCLEUS-ACCUMBENS DOPAMINE,HUMAN VISUAL-CORTEX,EVENT-RELATED FMRI,COGNITIVE CONTROL,HUMAN BRAIN,DECISION-MAKING,MONETARY REWARD,BASAL GANGLIA,ACTIVATION,NETWORK},
  language     = {eng},
  number       = {3},
  pages        = {607--615},
  title        = {The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands},
  url          = {http://dx.doi.org/10.1093/cercor/bhr134},
  volume       = {22},
  year         = {2012},
}

Chicago
Krebs, Ruth, Nico Böhler, Kenneth C Roberts, Allen W Song, and Marty G Woldorff. 2012. “The Involvement of the Dopaminergic Midbrain and Cortico-striatal-thalamic Circuits in the Integration of Reward Prospect and Attentional Task Demands.” Cerebral Cortex 22 (3): 607–615.
APA
Krebs, R., Böhler, N., Roberts, K. C., Song, A. W., & Woldorff, M. G. (2012). The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands. CEREBRAL CORTEX, 22(3), 607–615.
Vancouver
1.
Krebs R, Böhler N, Roberts KC, Song AW, Woldorff MG. The involvement of the dopaminergic midbrain and cortico-striatal-thalamic circuits in the integration of reward prospect and attentional task demands. CEREBRAL CORTEX. 2012;22(3):607–15.
MLA
Krebs, Ruth, Nico Böhler, Kenneth C Roberts, et al. “The Involvement of the Dopaminergic Midbrain and Cortico-striatal-thalamic Circuits in the Integration of Reward Prospect and Attentional Task Demands.” CEREBRAL CORTEX 22.3 (2012): 607–615. Print.