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Absorption, distribution and elimination of Carnosic acid: a natural Antioxidant from Rosmarinus officinalis, in Rats

Evelyne Doolaege UGent, Katleen Raes UGent, Filip De Vos UGent, Roland Verhé UGent and Stefaan De Smet UGent (2011) PLANT FOODS FOR HUMAN NUTRITION. 66(2). p.196-202
abstract
The absorption, distribution and elimination of carnosic acid, the main antioxidant found in rosemary was studied, in vivo, in rats. Therefore, carnosic acid was administrated in a single dose, intravenously (20.5 +/- 4.2 mg/kg) and orally (64.3 +/- 5.8 mg/kg), to four and nine rats, respectively. Blood samples were collected at different time points, and plasma concentrations of carnosic acid were determined using LC-MS. Furthermore, total collection of urine and feces was done during 4 h and 24 h for the intravenous and oral administrations, respectively. After euthanizing the rats, intestinal content, liver and muscle tissue were sampled to determine carnosic acid concentrations. The bioavailability of carnosic acid, after 360 min, was 40.1%. Traces of carnosic acid were found in the rats intestinal content, liver and muscle tissue of abdomen and legs. The recovery of carnosic acid in the feces, 24 h after oral administration, was 15.6 +/- 8.2%. Carnosic acid is absorbed into the bloodstream after oral administration in rats and is therefore bioavailable. It was found that carnosic acid in vivo is present in its free form and that its main elimination route is the fecal route.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Distribution, Elimination, Bioavailability, Absorption, Rats, Carnosic acid, LIVER, PLASMA, SAGE, BEEF, BROILER MEAT, ROSEMARY EXTRACT, DIETARY SUPPLEMENTATION, LIPID OXIDATION, PERFORMANCE LIQUID-CHROMATOGRAPHY, PLANT-EXTRACTS RICH
journal title
PLANT FOODS FOR HUMAN NUTRITION
Plant Food Hum. Nutr.
volume
66
issue
2
pages
196 - 202
Web of Science type
Article
Web of Science id
000293978000016
JCR category
FOOD SCIENCE & TECHNOLOGY
JCR impact factor
2.505 (2011)
JCR rank
19/128 (2011)
JCR quartile
1 (2011)
ISSN
0921-9668
DOI
10.1007/s11130-011-0233-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1895744
handle
http://hdl.handle.net/1854/LU-1895744
date created
2011-08-31 15:32:55
date last changed
2015-06-17 09:50:01
@article{1895744,
  abstract     = {The absorption, distribution and elimination of carnosic acid, the main antioxidant found in rosemary was studied, in vivo, in rats. Therefore, carnosic acid was administrated in a single dose, intravenously (20.5 +/- 4.2 mg/kg) and orally (64.3 +/- 5.8 mg/kg), to four and nine rats, respectively. Blood samples were collected at different time points, and plasma concentrations of carnosic acid were determined using LC-MS. Furthermore, total collection of urine and feces was done during 4 h and 24 h for the intravenous and oral administrations, respectively. After euthanizing the rats, intestinal content, liver and muscle tissue were sampled to determine carnosic acid concentrations. The bioavailability of carnosic acid, after 360 min, was 40.1\%. Traces of carnosic acid were found in the rats intestinal content, liver and muscle tissue of abdomen and legs. The recovery of carnosic acid in the feces, 24 h after oral administration, was 15.6 +/- 8.2\%. Carnosic acid is absorbed into the bloodstream after oral administration in rats and is therefore bioavailable. It was found that carnosic acid in vivo is present in its free form and that its main elimination route is the fecal route.},
  author       = {Doolaege, Evelyne and Raes, Katleen and De Vos, Filip and Verh{\'e}, Roland and De Smet, Stefaan},
  issn         = {0921-9668},
  journal      = {PLANT FOODS FOR HUMAN NUTRITION},
  keyword      = {Distribution,Elimination,Bioavailability,Absorption,Rats,Carnosic acid,LIVER,PLASMA,SAGE,BEEF,BROILER MEAT,ROSEMARY EXTRACT,DIETARY SUPPLEMENTATION,LIPID OXIDATION,PERFORMANCE LIQUID-CHROMATOGRAPHY,PLANT-EXTRACTS RICH},
  language     = {eng},
  number       = {2},
  pages        = {196--202},
  title        = {Absorption, distribution and elimination of Carnosic acid: a natural Antioxidant from Rosmarinus officinalis, in Rats},
  url          = {http://dx.doi.org/10.1007/s11130-011-0233-5},
  volume       = {66},
  year         = {2011},
}

Chicago
Doolaege, Evelyne, Katleen Raes, Filip De Vos, Roland Verhé, and Stefaan De Smet. 2011. “Absorption, Distribution and Elimination of Carnosic Acid: a Natural Antioxidant from Rosmarinus Officinalis, in Rats.” Plant Foods for Human Nutrition 66 (2): 196–202.
APA
Doolaege, E., Raes, K., De Vos, F., Verhé, R., & De Smet, S. (2011). Absorption, distribution and elimination of Carnosic acid: a natural Antioxidant from Rosmarinus officinalis, in Rats. PLANT FOODS FOR HUMAN NUTRITION, 66(2), 196–202.
Vancouver
1.
Doolaege E, Raes K, De Vos F, Verhé R, De Smet S. Absorption, distribution and elimination of Carnosic acid: a natural Antioxidant from Rosmarinus officinalis, in Rats. PLANT FOODS FOR HUMAN NUTRITION. 2011;66(2):196–202.
MLA
Doolaege, Evelyne, Katleen Raes, Filip De Vos, et al. “Absorption, Distribution and Elimination of Carnosic Acid: a Natural Antioxidant from Rosmarinus Officinalis, in Rats.” PLANT FOODS FOR HUMAN NUTRITION 66.2 (2011): 196–202. Print.