Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 4.72 MB
Add to list
  1. Search results
  2. The auxin signalling network translat...

The auxin signalling network translates dynamic input into robust patterning at the shoot apex

Teva Vernoux, Géraldine Brunoud, Etienne Farcot, Valérie Morin, Hilde Van Den Daele (UGent) , Jonathan Legrand, Marina Oliva, Pradeep Das, Antoine Larrieu, Darren Wells, et al.
(2011) MOLECULAR SYSTEMS BIOLOGY. 7.
Author
Organization
Abstract
The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex network of over 50 potentially interacting transcriptional activators and repressors, the auxin response factors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the shoot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive expression map and full interactome uncovered an unexpectedly simple distribution and structure of this pathway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity. We then tested and confirmed these predictions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunction with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex.
Keywords
TRANSPORT, APICAL MERISTEM, AUX/IAA GENES, GENE-EXPRESSION, PLANT DEVELOPMENT, RESPONSE FACTORS, ARABIDOPSIS-THALIANA, TIME RT-PCR, BOX PROTEIN TIR1, PHYLLOTAXIS, auxin, biosensor, live imaging, ODE, signalling

Downloads

  • Download
    (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 4.72 MB

Citation

Please use this url to cite or link to this publication:

MLA
Vernoux, Teva, et al. “The Auxin Signalling Network Translates Dynamic Input into Robust Patterning at the Shoot Apex.” MOLECULAR SYSTEMS BIOLOGY, vol. 7, 2011, doi:10.1038/msb.2011.39.
APA
Vernoux, T., Brunoud, G., Farcot, E., Morin, V., Van Den Daele, H., Legrand, J., … Traas, J. (2011). The auxin signalling network translates dynamic input into robust patterning at the shoot apex. MOLECULAR SYSTEMS BIOLOGY, 7. https://doi.org/10.1038/msb.2011.39
Chicago author-date
Vernoux, Teva, Géraldine Brunoud, Etienne Farcot, Valérie Morin, Hilde Van Den Daele, Jonathan Legrand, Marina Oliva, et al. 2011. “The Auxin Signalling Network Translates Dynamic Input into Robust Patterning at the Shoot Apex.” MOLECULAR SYSTEMS BIOLOGY 7. https://doi.org/10.1038/msb.2011.39.
Chicago author-date (all authors)
Vernoux, Teva, Géraldine Brunoud, Etienne Farcot, Valérie Morin, Hilde Van Den Daele, Jonathan Legrand, Marina Oliva, Pradeep Das, Antoine Larrieu, Darren Wells, Yann Guédon, Lynne Armitage, Franck Picard, Soazig Guyomarc’h, Coralie Cellier, Geraint Parry, Rachil Koumproglou, John H Doonan, Mark Estelle, Christophe Godin, Stefan Kepinski, Malcolm Bennett, Lieven De Veylder, and Jan Traas. 2011. “The Auxin Signalling Network Translates Dynamic Input into Robust Patterning at the Shoot Apex.” MOLECULAR SYSTEMS BIOLOGY 7. doi:10.1038/msb.2011.39.
Vancouver
1.
Vernoux T, Brunoud G, Farcot E, Morin V, Van Den Daele H, Legrand J, et al. The auxin signalling network translates dynamic input into robust patterning at the shoot apex. MOLECULAR SYSTEMS BIOLOGY. 2011;7.
IEEE
[1]
T. Vernoux et al., “The auxin signalling network translates dynamic input into robust patterning at the shoot apex,” MOLECULAR SYSTEMS BIOLOGY, vol. 7, 2011.
@article{1893722,
  abstract     = {{The plant hormone auxin is thought to provide positional information for patterning during development. It is still unclear, however, precisely how auxin is distributed across tissues and how the hormone is sensed in space and time. The control of gene expression in response to auxin involves a complex network of over 50 potentially interacting transcriptional activators and repressors, the auxin response factors (ARFs) and Aux/IAAs. Here, we perform a large-scale analysis of the Aux/IAA-ARF pathway in the shoot apex of Arabidopsis, where dynamic auxin-based patterning controls organogenesis. A comprehensive expression map and full interactome uncovered an unexpectedly simple distribution and structure of this pathway in the shoot apex. A mathematical model of the Aux/IAA-ARF network predicted a strong buffering capacity along with spatial differences in auxin sensitivity. We then tested and confirmed these predictions using a novel auxin signalling sensor that reports input into the signalling pathway, in conjunction with the published DR5 transcriptional output reporter. Our results provide evidence that the auxin signalling network is essential to create robust patterns at the shoot apex.}},
  articleno    = {{508}},
  author       = {{Vernoux, Teva and Brunoud, Géraldine and Farcot, Etienne and Morin, Valérie and Van Den Daele, Hilde and Legrand, Jonathan and Oliva, Marina and Das, Pradeep and Larrieu, Antoine and Wells, Darren and Guédon, Yann and Armitage, Lynne and Picard, Franck and Guyomarc'h, Soazig and Cellier, Coralie and Parry, Geraint and Koumproglou, Rachil and Doonan, John H and Estelle, Mark and Godin, Christophe and Kepinski, Stefan and Bennett, Malcolm and De Veylder, Lieven and Traas, Jan}},
  issn         = {{1744-4292}},
  journal      = {{MOLECULAR SYSTEMS BIOLOGY}},
  keywords     = {{TRANSPORT,APICAL MERISTEM,AUX/IAA GENES,GENE-EXPRESSION,PLANT DEVELOPMENT,RESPONSE FACTORS,ARABIDOPSIS-THALIANA,TIME RT-PCR,BOX PROTEIN TIR1,PHYLLOTAXIS,auxin,biosensor,live imaging,ODE,signalling}},
  language     = {{eng}},
  pages        = {{15}},
  title        = {{The auxin signalling network translates dynamic input into robust patterning at the shoot apex}},
  url          = {{http://doi.org/10.1038/msb.2011.39}},
  volume       = {{7}},
  year         = {{2011}},
}
Altmetric
View in Altmetric
Web of Science
Times cited: