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A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gut

David Hermans UGent, Frank Pasmans UGent, Marc Heyndrickx UGent, Filip Van Immerseel UGent, An Martel UGent, Kim Van Deun UGent and Freddy Haesebrouck UGent (2012) CRITICAL REVIEWS IN MICROBIOLOGY. 38(1). p.17-29
abstract
Campylobacter enteritis is the most reported zoonotic disease in many developed countries where it imposes a serious health burden. Campylobacter transmission to humans occurs primarily through the chicken vector. Chicks are regarded as a natural host for Campylobacter species and are colonized with C. jejuni in particular. But despite carrying a very high bacterial load in their gastrointestinal tract, these birds, in contrast to humans, do not develop pathological signs. It seems that in chickens C. jejuni principally harbors in the cecal mucosal crypts, where an inefficient inflammatory response fails to clear the bacterium from the gut. Recent intensive research resulted in an increased insight into the cross talk between C. jejuni and its avian host. This review discusses the chicken intestinal mucosal immune response upon C. jejuni entrance, leading to tolerance and persistent cecal colonization. It might in addition provide a solid base for further research regarding this topic aiming to fully understand the host-bacterium dynamics of C. jejuni in chicks and to develop effective control measures to clear this zoonotic pathogen from poultry lines.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
immune response, COMMENSAL BACTERIA, persistent colonization, CYTOKINE RESPONSES, tolerance, broiler chicken, Campylobacter jejuni, INTESTINAL EPITHELIAL-CELLS, CYTOLETHAL DISTENDING TOXIN, FIELD GEL-ELECTROPHORESIS, IN-VIVO, MATERNAL ANTIBODIES, CECAL COLONIZATION, GASTROINTESTINAL-TRACT, TEMPERATE BACTERIOPHAGES
journal title
CRITICAL REVIEWS IN MICROBIOLOGY
Crit. Rev. Microbiol.
volume
38
issue
1
pages
17 - 29
Web of Science type
Review
Web of Science id
000299093000002
JCR category
MICROBIOLOGY
JCR impact factor
5.065 (2012)
JCR rank
17/116 (2012)
JCR quartile
1 (2012)
ISSN
1040-841X
DOI
10.3109/1040841X.2011.615298
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
1888799
handle
http://hdl.handle.net/1854/LU-1888799
date created
2011-08-16 09:05:49
date last changed
2013-05-14 14:06:37
@article{1888799,
  abstract     = {Campylobacter enteritis is the most reported zoonotic disease in many developed countries where it imposes a serious health burden. Campylobacter transmission to humans occurs primarily through the chicken vector. Chicks are regarded as a natural host for Campylobacter species and are colonized with C. jejuni in particular. But despite carrying a very high bacterial load in their gastrointestinal tract, these birds, in contrast to humans, do not develop pathological signs. It seems that in chickens C. jejuni principally harbors in the cecal mucosal crypts, where an inefficient inflammatory response fails to clear the bacterium from the gut. Recent intensive research resulted in an increased insight into the cross talk between C. jejuni and its avian host. This review discusses the chicken intestinal mucosal immune response upon C. jejuni entrance, leading to tolerance and persistent cecal colonization. It might in addition provide a solid base for further research regarding this topic aiming to fully understand the host-bacterium dynamics of C. jejuni in chicks and to develop effective control measures to clear this zoonotic pathogen from poultry lines.},
  author       = {Hermans, David and Pasmans, Frank and Heyndrickx, Marc and Van Immerseel, Filip and Martel, An and Van Deun, Kim and Haesebrouck, Freddy},
  issn         = {1040-841X},
  journal      = {CRITICAL REVIEWS IN MICROBIOLOGY},
  keyword      = {immune response,COMMENSAL BACTERIA,persistent colonization,CYTOKINE RESPONSES,tolerance,broiler chicken,Campylobacter jejuni,INTESTINAL EPITHELIAL-CELLS,CYTOLETHAL DISTENDING TOXIN,FIELD GEL-ELECTROPHORESIS,IN-VIVO,MATERNAL ANTIBODIES,CECAL COLONIZATION,GASTROINTESTINAL-TRACT,TEMPERATE BACTERIOPHAGES},
  language     = {eng},
  number       = {1},
  pages        = {17--29},
  title        = {A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gut},
  url          = {http://dx.doi.org/10.3109/1040841X.2011.615298},
  volume       = {38},
  year         = {2012},
}

Chicago
Hermans, David, Frank Pasmans, Marc Heyndrickx, Filip Van Immerseel, An Martel, Kim Van Deun, and Freddy Haesebrouck. 2012. “A Tolerogenic Mucosal Immune Response Leads to Persistent Campylobacter Jejuni Colonization in the Chicken Gut.” Critical Reviews in Microbiology 38 (1): 17–29.
APA
Hermans, David, Pasmans, F., Heyndrickx, M., Van Immerseel, F., Martel, A., Van Deun, K., & Haesebrouck, F. (2012). A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gut. CRITICAL REVIEWS IN MICROBIOLOGY, 38(1), 17–29.
Vancouver
1.
Hermans D, Pasmans F, Heyndrickx M, Van Immerseel F, Martel A, Van Deun K, et al. A tolerogenic mucosal immune response leads to persistent Campylobacter jejuni colonization in the chicken gut. CRITICAL REVIEWS IN MICROBIOLOGY. 2012;38(1):17–29.
MLA
Hermans, David, Frank Pasmans, Marc Heyndrickx, et al. “A Tolerogenic Mucosal Immune Response Leads to Persistent Campylobacter Jejuni Colonization in the Chicken Gut.” CRITICAL REVIEWS IN MICROBIOLOGY 38.1 (2012): 17–29. Print.