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HMGB1 release by inflammasomes

(2011) VIRULENCE. 2(2). p.162-165
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Abstract
High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical danger signal that regulates inflammatory and repair responses. Under conditions of infection, injury and sterile inflammation, HMGB1 can be passively released from damaged cells or actively secreted from activated immune cells. Inflammasomes, large caspase-1-activating protein complexes, were recently shown to play a critical role in mediating the extracellular release of HMGB1 from activated and infected immune cells.
Keywords
inflammasome, PROINFLAMMATORY ACTIVITY, caspase-1, NLR, danger signal, alarmin, INFLAMMATION, inflammation, NECROTIC CELLS, DENDRITIC CELLS, RECOMBINANT HMGB1, HMGB1, infection, NLRC4, NLRP3, UNCONVENTIONAL PROTEIN SECRETION, MOBILITY GROUP BOX-1, GLYCATION END-PRODUCTS, IN-VIVO, TOLL-LIKE RECEPTORS

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Citation

Please use this url to cite or link to this publication:

Chicago
Vande Walle, Lieselotte, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. 2011. “HMGB1 Release by Inflammasomes.” Virulence 2 (2): 162–165.
APA
Vande Walle, L., Kanneganti, T.-D., & Lamkanfi, M. (2011). HMGB1 release by inflammasomes. VIRULENCE, 2(2), 162–165.
Vancouver
1.
Vande Walle L, Kanneganti T-D, Lamkanfi M. HMGB1 release by inflammasomes. VIRULENCE. 2011;2(2):162–5.
MLA
Vande Walle, Lieselotte, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. “HMGB1 Release by Inflammasomes.” VIRULENCE 2.2 (2011): 162–165. Print.
@article{1886923,
  abstract     = {High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical danger signal that regulates inflammatory and repair responses. Under conditions of infection, injury and sterile inflammation, HMGB1 can be passively released from damaged cells or actively secreted from activated immune cells. Inflammasomes, large caspase-1-activating protein complexes, were recently shown to play a critical role in mediating the extracellular release of HMGB1 from activated and infected immune cells.},
  author       = {Vande Walle, Lieselotte and Kanneganti, Thirumala-Devi and Lamkanfi, Mohamed},
  issn         = {2150-5594},
  journal      = {VIRULENCE},
  keyword      = {inflammasome,PROINFLAMMATORY ACTIVITY,caspase-1,NLR,danger signal,alarmin,INFLAMMATION,inflammation,NECROTIC CELLS,DENDRITIC CELLS,RECOMBINANT HMGB1,HMGB1,infection,NLRC4,NLRP3,UNCONVENTIONAL PROTEIN SECRETION,MOBILITY GROUP BOX-1,GLYCATION END-PRODUCTS,IN-VIVO,TOLL-LIKE RECEPTORS},
  language     = {eng},
  number       = {2},
  pages        = {162--165},
  title        = {HMGB1 release by inflammasomes},
  url          = {http://dx.doi.org/10.4161/viru.2.2.15480},
  volume       = {2},
  year         = {2011},
}

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