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HMGB1 release by inflammasomes

Lieselotte Vande Walle UGent, Thirumala-Devi Kanneganti and Mohamed Lamkanfi UGent (2011) VIRULENCE. 2(2). p.162-165
abstract
High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical danger signal that regulates inflammatory and repair responses. Under conditions of infection, injury and sterile inflammation, HMGB1 can be passively released from damaged cells or actively secreted from activated immune cells. Inflammasomes, large caspase-1-activating protein complexes, were recently shown to play a critical role in mediating the extracellular release of HMGB1 from activated and infected immune cells.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
inflammasome, PROINFLAMMATORY ACTIVITY, caspase-1, NLR, danger signal, alarmin, INFLAMMATION, inflammation, NECROTIC CELLS, DENDRITIC CELLS, RECOMBINANT HMGB1, HMGB1, infection, NLRC4, NLRP3, UNCONVENTIONAL PROTEIN SECRETION, MOBILITY GROUP BOX-1, GLYCATION END-PRODUCTS, IN-VIVO, TOLL-LIKE RECEPTORS
journal title
VIRULENCE
Virulence
volume
2
issue
2
pages
162 - 165
Web of Science type
Article
Web of Science id
000292523500013
JCR category
MICROBIOLOGY
JCR impact factor
2.264 (2011)
JCR rank
64/111 (2011)
JCR quartile
3 (2011)
ISSN
2150-5594
DOI
10.4161/viru.2.2.15480
language
English
UGent publication?
yes
classification
A1
additional info
addendum to Lamkanfi et al. (2010) Inflammasome-dependent release of the alarmin HMGB1 in endotoxemia, J. Immunol. 185(7), 4385-4392, DOI 10.4049/jimmunol.1000803
copyright statement
I have transferred the copyright for this publication to the publisher
id
1886923
handle
http://hdl.handle.net/1854/LU-1886923
date created
2011-08-09 12:00:51
date last changed
2016-12-19 15:46:25
@article{1886923,
  abstract     = {High-mobility group box 1 (HMGB1) was originally identified as a highly conserved nuclear DNA-binding protein that participates in DNA replication, repair and transcriptional regulation of gene expression. Although the nuclear role of HMGB1 is not quite understood, recent studies characterized the emerging role of extracellular HMGB1 as a prototypical danger signal that regulates inflammatory and repair responses. Under conditions of infection, injury and sterile inflammation, HMGB1 can be passively released from damaged cells or actively secreted from activated immune cells. Inflammasomes, large caspase-1-activating protein complexes, were recently shown to play a critical role in mediating the extracellular release of HMGB1 from activated and infected immune cells.},
  author       = {Vande Walle, Lieselotte and Kanneganti, Thirumala-Devi and Lamkanfi, Mohamed},
  issn         = {2150-5594},
  journal      = {VIRULENCE},
  keyword      = {inflammasome,PROINFLAMMATORY ACTIVITY,caspase-1,NLR,danger signal,alarmin,INFLAMMATION,inflammation,NECROTIC CELLS,DENDRITIC CELLS,RECOMBINANT HMGB1,HMGB1,infection,NLRC4,NLRP3,UNCONVENTIONAL PROTEIN SECRETION,MOBILITY GROUP BOX-1,GLYCATION END-PRODUCTS,IN-VIVO,TOLL-LIKE RECEPTORS},
  language     = {eng},
  number       = {2},
  pages        = {162--165},
  title        = {HMGB1 release by inflammasomes},
  url          = {http://dx.doi.org/10.4161/viru.2.2.15480},
  volume       = {2},
  year         = {2011},
}

Chicago
Vande Walle, Lieselotte, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. 2011. “HMGB1 Release by Inflammasomes.” Virulence 2 (2): 162–165.
APA
Vande Walle, L., Kanneganti, T.-D., & Lamkanfi, M. (2011). HMGB1 release by inflammasomes. VIRULENCE, 2(2), 162–165.
Vancouver
1.
Vande Walle L, Kanneganti T-D, Lamkanfi M. HMGB1 release by inflammasomes. VIRULENCE. 2011;2(2):162–5.
MLA
Vande Walle, Lieselotte, Thirumala-Devi Kanneganti, and Mohamed Lamkanfi. “HMGB1 Release by Inflammasomes.” VIRULENCE 2.2 (2011): 162–165. Print.