Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation
- Author
- RSJ Gapasin, Hans Nelis (UGent) , M Chair and Patrick Sorgeloos (UGent)
- Organization
- Abstract
- Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (Dicentrarchus labrax) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in an oil emulsion (Selco) at 20 % and 40 % concentrations (w/w) were bioencapsulated in Artemia (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentrations in the tissue were analysed by high-performance liquid chromatrography (HPLC). Fish fed 40 % 'medicated' Artemia assimilated significantly higher levels of chemotherapeutics compared with those fed 20 % 'medicated' Artemia. Chemotherapeutics given at 40 % reached peak levels (19.3 mu g TMP/g DW and 23.31 mu g SMX/g DW) within 2 h while those at 20 % peaked (8.74 mu g TMP/g DW and 6.73 mu g SMX/g DW) after 5 h. TMP persisted in the tissues longer (up to 72 h) than SMX (12-16 h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.
- Keywords
- SULFAMETHOXAZOLE, ARTEMIA, TRIMETHOPRIM
Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-188049
- MLA
- Gapasin, RSJ, et al. “Drug Assimilation in the Tissue of European Sea Bass (Dicentrarchus Labrax) Fry Delivered Orally through Bioencapsulation.” JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE, vol. 12, no. 1, 1996, pp. 39–42, doi:10.1111/j.1439-0426.1996.tb00057.x.
- APA
- Gapasin, R., Nelis, H., Chair, M., & Sorgeloos, P. (1996). Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation. JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE, 12(1), 39–42. https://doi.org/10.1111/j.1439-0426.1996.tb00057.x
- Chicago author-date
- Gapasin, RSJ, Hans Nelis, M Chair, and Patrick Sorgeloos. 1996. “Drug Assimilation in the Tissue of European Sea Bass (Dicentrarchus Labrax) Fry Delivered Orally through Bioencapsulation.” JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE 12 (1): 39–42. https://doi.org/10.1111/j.1439-0426.1996.tb00057.x.
- Chicago author-date (all authors)
- Gapasin, RSJ, Hans Nelis, M Chair, and Patrick Sorgeloos. 1996. “Drug Assimilation in the Tissue of European Sea Bass (Dicentrarchus Labrax) Fry Delivered Orally through Bioencapsulation.” JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE 12 (1): 39–42. doi:10.1111/j.1439-0426.1996.tb00057.x.
- Vancouver
- 1.Gapasin R, Nelis H, Chair M, Sorgeloos P. Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation. JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE. 1996;12(1):39–42.
- IEEE
- [1]R. Gapasin, H. Nelis, M. Chair, and P. Sorgeloos, “Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation,” JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE, vol. 12, no. 1, pp. 39–42, 1996.
@article{188049,
abstract = {{Assimilation levels of the antibacterials trimethoprim (TMP) and sulfamethoxazole (SMX) in sea bass (Dicentrarchus labrax) fry tissue administered orally were investigated. A 1:5 TMP and SMX combination incorporated in an oil emulsion (Selco) at 20 % and 40 % concentrations (w/w) were bioencapsulated in Artemia (Instar II) nauplii. Chemotherapeutics-loaded ('medicated') nauplii were fed to the sea bass fry and drug concentrations in the tissue were analysed by high-performance liquid chromatrography (HPLC). Fish fed 40 % 'medicated' Artemia assimilated significantly higher levels of chemotherapeutics compared with those fed 20 % 'medicated' Artemia. Chemotherapeutics given at 40 % reached peak levels (19.3 mu g TMP/g DW and 23.31 mu g SMX/g DW) within 2 h while those at 20 % peaked (8.74 mu g TMP/g DW and 6.73 mu g SMX/g DW) after 5 h. TMP persisted in the tissues longer (up to 72 h) than SMX (12-16 h), suggesting a more efficient uptake and retention of the former and/or faster metabolism and elimination of the latter.}},
author = {{Gapasin, RSJ and Nelis, Hans and Chair, M and Sorgeloos, Patrick}},
issn = {{0175-8659}},
journal = {{JOURNAL OF APPLIED ICHTHYOLOGY-ZEITSCHRIFT FUR ANGEWANDTE ICHTHYOLOGIE}},
keywords = {{SULFAMETHOXAZOLE,ARTEMIA,TRIMETHOPRIM}},
language = {{eng}},
number = {{1}},
pages = {{39--42}},
title = {{Drug assimilation in the tissue of European sea bass (Dicentrarchus labrax) fry delivered orally through bioencapsulation}},
url = {{http://doi.org/10.1111/j.1439-0426.1996.tb00057.x}},
volume = {{12}},
year = {{1996}},
}
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