Ghent University Academic Bibliography

Advanced

Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study

Kristien Van Reeth UGent, Hans Nauwynck UGent and Maurice Pensaert (1996) VETERINARY MICROBIOLOGY. 48(3-4). p.325-335
abstract
Dual infections of pigs with porcine reproductive and respiratory syndrome virus (PRRSV) followed by a second common respiratory virus, either porcine respiratory coronavirus (PRCV) or swine influenza virus (SIV), were studied. The aim was to determine if dual infections, as compared to single virus infections, result in enhanced clinical manifestations. It was also examined if PRRSV replication affects replication of PRCV or SIV in the respiratory tract. Groups of conventional 10 week old pigs were inoculated with PRRSV-only (3 pigs), PRCV-only (4 pigs) or SIV-only (4 pigs). Dual inoculations with PRRSV-PRCV (4 pigs) and PRRSV-SIV (3 groups of 3, 4 and 5 pigs) were performed at a 3 day interval. A group of uninoculated control pigs (8 pigs) was included. The infection with PRRSV-only induced a transient fever (40.2 degrees C) at 2 DPI, but no respiratory signs. The PRCV-only infection remained subclinical. The SIV-only infection resulted in a one day fever (40.1 degrees C) with moderate tachypnoea and dyspnoea. Mean weight gain in the virus-inoculated groups was retarded compared with the control group. The PRRSV-PRCV infection induced a 9 day lasting fever (peak 40.9 degrees C) with tachypnoea, dyspnoea and productive coughing. The PRRSV-SIV infection resulted in fever and respiratory signs in all 3 groups. Clinical signs, however, were more pronounced in group 1 than in groups 2 and 3. Pigs of group 1 showed fever during 10 days (peak 41.4 degrees C), tachypnoea, marked dyspnoea with abdominal breathing, and a productive cough. Pigs of groups 2 and 3 had fever for 5 and 3 days (peaks 40.6 and 40.3 degrees C) respectively and mild respiratory disorders. Mean weight gain during 14 DPI of the 2nd virus was 5.9 kg in the PRRSV-PRCV group and 4.0, 6.8 and 6.7 ki: in PRRSV-SIV groups 1, 2 and 3 respectively. Mean weight gain during the corresponding period in the PRRSV-only group was 8.6 kg. It was concluded that dual infections with viruses causes more severe disease and growth retardation than single PRRSV infection. PRCV excretion curves were similar in single and dual virus inoculated groups. Excretion of SIV was delayed by 2 days in the dual inoculated pigs. Thus, replication of the second virus is not (PRCV) or only slightly (SIV) affected by a prior infection with PRRSV.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
porcine respiratory coronavirus, porcine reproductive and respiratory syndrome virus, swine influenza virus, dual infections, pigs, TRANSMISSIBLE GASTROENTERITIS
journal title
VETERINARY MICROBIOLOGY
Vet. Microbiol.
volume
48
issue
3-4
pages
325 - 335
Web of Science type
Article
ISSN
0378-1135
DOI
10.1016/0378-1135(95)00145-X
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
187517
handle
http://hdl.handle.net/1854/LU-187517
date created
2004-01-14 13:41:00
date last changed
2016-12-19 15:37:58
@article{187517,
  abstract     = {Dual infections of pigs with porcine reproductive and respiratory syndrome virus (PRRSV) followed by a second common respiratory virus, either porcine respiratory coronavirus (PRCV) or swine influenza virus (SIV), were studied. The aim was to determine if dual infections, as compared to single virus infections, result in enhanced clinical manifestations. It was also examined if PRRSV replication affects replication of PRCV or SIV in the respiratory tract. Groups of conventional 10 week old pigs were inoculated with PRRSV-only (3 pigs), PRCV-only (4 pigs) or SIV-only (4 pigs). Dual inoculations with PRRSV-PRCV (4 pigs) and PRRSV-SIV (3 groups of 3, 4 and 5 pigs) were performed at a 3 day interval. A group of uninoculated control pigs (8 pigs) was included. The infection with PRRSV-only induced a transient fever (40.2 degrees C) at 2 DPI, but no respiratory signs. The PRCV-only infection remained subclinical. The SIV-only infection resulted in a one day fever (40.1 degrees C) with moderate tachypnoea and dyspnoea. Mean weight gain in the virus-inoculated groups was retarded compared with the control group.
The PRRSV-PRCV infection induced a 9 day lasting fever (peak 40.9 degrees C) with tachypnoea, dyspnoea and productive coughing. The PRRSV-SIV infection resulted in fever and respiratory signs in all 3 groups. Clinical signs, however, were more pronounced in group 1 than in groups 2 and 3. Pigs of group 1 showed fever during 10 days (peak 41.4 degrees C), tachypnoea, marked dyspnoea with abdominal breathing, and a productive cough. Pigs of groups 2 and 3 had fever for 5 and 3 days (peaks 40.6 and 40.3 degrees C) respectively and mild respiratory disorders. Mean weight gain during 14 DPI of the 2nd virus was 5.9 kg in the PRRSV-PRCV group and 4.0, 6.8 and 6.7 ki: in PRRSV-SIV groups 1, 2 and 3 respectively. Mean weight gain during the corresponding period in the PRRSV-only group was 8.6 kg. It was concluded that dual infections with viruses causes more severe disease and growth retardation than single PRRSV infection.
PRCV excretion curves were similar in single and dual virus inoculated groups. Excretion of SIV was delayed by 2 days in the dual inoculated pigs. Thus, replication of the second virus is not (PRCV) or only slightly (SIV) affected by a prior infection with PRRSV.},
  author       = {Van Reeth, Kristien and Nauwynck, Hans and Pensaert, Maurice},
  issn         = {0378-1135},
  journal      = {VETERINARY MICROBIOLOGY},
  keyword      = {porcine respiratory coronavirus,porcine reproductive and respiratory syndrome virus,swine influenza virus,dual infections,pigs,TRANSMISSIBLE GASTROENTERITIS},
  language     = {eng},
  number       = {3-4},
  pages        = {325--335},
  title        = {Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study},
  url          = {http://dx.doi.org/10.1016/0378-1135(95)00145-X},
  volume       = {48},
  year         = {1996},
}

Chicago
Van Reeth, Kristien, Hans Nauwynck, and Maurice Pensaert. 1996. “Dual Infections of Feeder Pigs with Porcine Reproductive and Respiratory Syndrome Virus Followed by Porcine Respiratory Coronavirus or Swine Influenza Virus: a Clinical and Virological Study.” Veterinary Microbiology 48 (3-4): 325–335.
APA
Van Reeth, K., Nauwynck, H., & Pensaert, M. (1996). Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study. VETERINARY MICROBIOLOGY, 48(3-4), 325–335.
Vancouver
1.
Van Reeth K, Nauwynck H, Pensaert M. Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study. VETERINARY MICROBIOLOGY. 1996;48(3-4):325–35.
MLA
Van Reeth, Kristien, Hans Nauwynck, and Maurice Pensaert. “Dual Infections of Feeder Pigs with Porcine Reproductive and Respiratory Syndrome Virus Followed by Porcine Respiratory Coronavirus or Swine Influenza Virus: a Clinical and Virological Study.” VETERINARY MICROBIOLOGY 48.3-4 (1996): 325–335. Print.