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An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice

Bram Trachet (UGent) , Marjolijn Renard (UGent) , Gianluca De Santis (UGent) , Steven Staelens (UGent) , Julie De Backer (UGent) , Luca Antiga, Bart Loeys (UGent) and Patrick Segers (UGent)
(2011) ANNALS OF BIOMEDICAL ENGINEERING. 39(9). p.2430-2444
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Locally disturbed flow has been suggested to play a (modulating) role in abdominal aortic aneurysm (AAA) formation, but no longitudinal studies have been performed yet due to (a.o.) a lack of human data prior to AAA formation. In this study we made use of recent advances in small animal imaging technology in order to set up entirely mouse-specific computational fluid dynamics (CFD) simulations of the abdominal aorta in an established ApoE 2/2 mouse model of AAA formation, combining (i) in vivo contrast-enhanced micro-CT scans (geometrical model) and (ii) in vivo high-frequency ultrasound scans (boundary conditions). Resulting areas of disturbed flow at baseline were compared to areas of AAA at end-stage. Qualitative results showed that AAA dimension is maximal in areas that are situated proximal to those areas that experience most disturbed flow in three out of four S developing an AAA. Although further quantitative analysis did not reveal any obvious relationship between areas that experience most disturbed flow and the end-stage AAA dimensions, we cannot exclude that hemodynamics play a role in the initial phases of AAA formation. Due to its mouse-specific and in vivo nature, the presented methodology can be used in future research to link detailed and animal-specific (baseline) hemodynamics to (end-stage) arterial disease in longitudinal studies in mice.
Keywords
High-frequency ultrasound, ApoE -/- mouse model, Abdominal aortic aneurysm, Mouse-specific hemodynamics, Computational fluid dynamics, Contrast-enhanced micro-CT, ABDOMINAL AORTIC-ANEURYSMS, WALL SHEAR-STRESS, COMPUTATIONAL FLUID-DYNAMICS, SPINAL-CORD-INJURY, E-DEFICIENT MICE, PULSATILE FLOW, BLOOD-FLOW, CEREBRAL ANEURYSM, ATHEROSCLEROSIS, QUANTIFICATION

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Citation

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MLA
Trachet, Bram, Marjolijn Renard, Gianluca De Santis, et al. “An Integrated Framework to Quantitatively Link Mouse-specific Hemodynamics to Aneurysm Formation in Angiotensin II-infused ApoE -/- Mice.” ANNALS OF BIOMEDICAL ENGINEERING 39.9 (2011): 2430–2444. Print.
APA
Trachet, B., Renard, M., De Santis, G., Staelens, S., De Backer, J., Antiga, L., Loeys, B., et al. (2011). An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice. ANNALS OF BIOMEDICAL ENGINEERING, 39(9), 2430–2444.
Chicago author-date
Trachet, Bram, Marjolijn Renard, Gianluca De Santis, Steven Staelens, Julie De Backer, Luca Antiga, Bart Loeys, and Patrick Segers. 2011. “An Integrated Framework to Quantitatively Link Mouse-specific Hemodynamics to Aneurysm Formation in Angiotensin II-infused ApoE -/- Mice.” Annals of Biomedical Engineering 39 (9): 2430–2444.
Chicago author-date (all authors)
Trachet, Bram, Marjolijn Renard, Gianluca De Santis, Steven Staelens, Julie De Backer, Luca Antiga, Bart Loeys, and Patrick Segers. 2011. “An Integrated Framework to Quantitatively Link Mouse-specific Hemodynamics to Aneurysm Formation in Angiotensin II-infused ApoE -/- Mice.” Annals of Biomedical Engineering 39 (9): 2430–2444.
Vancouver
1.
Trachet B, Renard M, De Santis G, Staelens S, De Backer J, Antiga L, et al. An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice. ANNALS OF BIOMEDICAL ENGINEERING. 2011;39(9):2430–44.
IEEE
[1]
B. Trachet et al., “An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice,” ANNALS OF BIOMEDICAL ENGINEERING, vol. 39, no. 9, pp. 2430–2444, 2011.
@article{1870245,
  abstract     = {Locally disturbed flow has been suggested to play a (modulating) role in abdominal aortic aneurysm (AAA) formation, but no longitudinal studies have been performed yet due to (a.o.) a lack of human data prior to AAA formation. In this study we made use of recent advances in small animal imaging technology in order to set up entirely mouse-specific computational fluid dynamics (CFD) simulations of the abdominal aorta in an established ApoE 2/2 mouse model of AAA formation, combining (i) in vivo contrast-enhanced micro-CT scans (geometrical model) and (ii) in vivo high-frequency ultrasound scans (boundary conditions). Resulting areas of disturbed flow at baseline were compared to areas of AAA at end-stage. Qualitative results showed that AAA dimension is maximal in areas that are situated proximal to those areas that experience most disturbed flow in three out of four S developing an AAA. Although further quantitative analysis did not reveal any obvious relationship between areas that experience most disturbed flow and the end-stage AAA dimensions, we cannot exclude that hemodynamics play a role in the initial phases of AAA formation. Due to its mouse-specific and in vivo nature, the presented methodology can be used in future research to link detailed and animal-specific (baseline) hemodynamics to (end-stage) arterial disease in longitudinal studies in mice.},
  author       = {Trachet, Bram and Renard, Marjolijn and De Santis, Gianluca and Staelens, Steven and De Backer, Julie and Antiga, Luca and Loeys, Bart and Segers, Patrick},
  issn         = {0090-6964},
  journal      = {ANNALS OF BIOMEDICAL ENGINEERING},
  keywords     = {High-frequency ultrasound,ApoE -/- mouse model,Abdominal aortic aneurysm,Mouse-specific hemodynamics,Computational fluid dynamics,Contrast-enhanced micro-CT,ABDOMINAL AORTIC-ANEURYSMS,WALL SHEAR-STRESS,COMPUTATIONAL FLUID-DYNAMICS,SPINAL-CORD-INJURY,E-DEFICIENT MICE,PULSATILE FLOW,BLOOD-FLOW,CEREBRAL ANEURYSM,ATHEROSCLEROSIS,QUANTIFICATION},
  language     = {eng},
  number       = {9},
  pages        = {2430--2444},
  title        = {An integrated framework to quantitatively link mouse-specific hemodynamics to aneurysm formation in angiotensin II-infused ApoE -/- mice},
  url          = {http://dx.doi.org/10.1007/s10439-011-0330-5},
  volume       = {39},
  year         = {2011},
}

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