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Does visual cortex lactate increase following photic stimulation in migraine without aura patients?: a functional 1H-MRS study

Harmen Reyngoudt UGent, Koen Paemeleire UGent, Anneloor Dierickx UGent, Benedicte Descamps UGent, Pieter Vandemaele UGent, Yves De Deene UGent and Eric Achten UGent (2011) JOURNAL OF HEADACHE AND PAIN. 12(3). p.295-302
abstract
Proton magnetic resonance spectroscopy ((1)H-MRS) has been used in a number of studies to assess noninvasively the temporal changes of lactate (Lac) in the activated human brain. Migraine neurobiology involves lack of cortical habituation to repetitive stimuli and a mitochondrial component has been put forward. Our group has recently demonstrated a reduction in the high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) in the occipital lobe of migraine without aura (MwoA) patients, at least in a subgroup, in a phosphorus MRS ((31)P-MRS) study. In previous studies, basal Lac levels or photic stimulation (PS)-induced Lac levels were found to be increased in patients with migraine with aura (MwA) and migraine patients with visual symptoms and paraesthesia, paresia and/or dysphasia, respectively. The aim of this study was to perform functional (1)H-MRS at 3 T in 20 MwoA patients and 20 control subjects. Repetitive visual stimulation was applied using MR-compatible goggles with 8 Hz checkerboard stimulation during 12 min. We did not observe any significant differences in signal integrals, ratios and absolute metabolite concentrations, including Lac, between MwoA patients and controls before PS. Lac also did not increase significantly during and following PS, both for MwoA patients and controls. Subtle Lac changes, smaller than the sensitivity threshold (i.e. estimated at 0.1-0.2 mu mol/g at 3 T), cannot be detected by MRS. Our study does, however, argue against a significant switch to non-aerobic glucose metabolism during long-lasting PS of the visual cortex in MwoA patients.
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author
organization
alternative title
Does visual cortex lactate increase following photic stimulation in migraine without aura patients? : a functional (1)H-MRS study
year
type
journalArticle (original)
publication status
published
subject
keyword
Migraine without aura, MAGNETIC-RESONANCE-SPECTROSCOPY, Functional (1)H-MRS, Lactate, Visual cortex, Absolute quantification, H-1-NMR, DECREASE, GENETICS, QUANTITATION, BRAIN, NEURAL ACTIVITY, GLUCOSE-UTILIZATION, NEURONAL ACTIVATION, OXIDATIVE-METABOLISM
journal title
JOURNAL OF HEADACHE AND PAIN
J. Headache Pain
volume
12
issue
3
pages
295 - 302
Web of Science type
Article
Web of Science id
000292908100006
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.427 (2011)
JCR rank
81/190 (2011)
JCR quartile
2 (2011)
ISSN
1129-2369
DOI
10.1007/s10194-011-0295-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
1866744
handle
http://hdl.handle.net/1854/LU-1866744
date created
2011-08-04 11:17:58
date last changed
2011-08-09 13:42:22
@article{1866744,
  abstract     = {Proton magnetic resonance spectroscopy ((1)H-MRS) has been used in a number of studies to assess noninvasively the temporal changes of lactate (Lac) in the activated human brain. Migraine neurobiology involves lack of cortical habituation to repetitive stimuli and a mitochondrial component has been put forward. Our group has recently demonstrated a reduction in the high-energy phosphates adenosine triphosphate (ATP) and phosphocreatine (PCr) in the occipital lobe of migraine without aura (MwoA) patients, at least in a subgroup, in a phosphorus MRS ((31)P-MRS) study. In previous studies, basal Lac levels or photic stimulation (PS)-induced Lac levels were found to be increased in patients with migraine with aura (MwA) and migraine patients with visual symptoms and paraesthesia, paresia and/or dysphasia, respectively. The aim of this study was to perform functional (1)H-MRS at 3 T in 20 MwoA patients and 20 control subjects. Repetitive visual stimulation was applied using MR-compatible goggles with 8 Hz checkerboard stimulation during 12 min. We did not observe any significant differences in signal integrals, ratios and absolute metabolite concentrations, including Lac, between MwoA patients and controls before PS. Lac also did not increase significantly during and following PS, both for MwoA patients and controls. Subtle Lac changes, smaller than the sensitivity threshold (i.e. estimated at 0.1-0.2 mu mol/g at 3 T), cannot be detected by MRS. Our study does, however, argue against a significant switch to non-aerobic glucose metabolism during long-lasting PS of the visual cortex in MwoA patients.},
  author       = {Reyngoudt, Harmen and Paemeleire, Koen and Dierickx, Anneloor and Descamps, Benedicte and Vandemaele, Pieter and De Deene, Yves and Achten, Eric},
  issn         = {1129-2369},
  journal      = {JOURNAL OF HEADACHE AND PAIN},
  keyword      = {Migraine without aura,MAGNETIC-RESONANCE-SPECTROSCOPY,Functional (1)H-MRS,Lactate,Visual cortex,Absolute quantification,H-1-NMR,DECREASE,GENETICS,QUANTITATION,BRAIN,NEURAL ACTIVITY,GLUCOSE-UTILIZATION,NEURONAL ACTIVATION,OXIDATIVE-METABOLISM},
  language     = {eng},
  number       = {3},
  pages        = {295--302},
  title        = {Does visual cortex lactate increase following photic stimulation in migraine without aura patients?: a functional 1H-MRS study},
  url          = {http://dx.doi.org/10.1007/s10194-011-0295-7},
  volume       = {12},
  year         = {2011},
}

Chicago
Reyngoudt, Harmen, Koen Paemeleire, Anneloor Dierickx, Benedicte Descamps, Pieter Vandemaele, Yves De Deene, and Eric Achten. 2011. “Does Visual Cortex Lactate Increase Following Photic Stimulation in Migraine Without Aura Patients?: a Functional 1H-MRS Study.” Journal of Headache and Pain 12 (3): 295–302.
APA
Reyngoudt, H., Paemeleire, K., Dierickx, A., Descamps, B., Vandemaele, P., De Deene, Y., & Achten, E. (2011). Does visual cortex lactate increase following photic stimulation in migraine without aura patients?: a functional 1H-MRS study. JOURNAL OF HEADACHE AND PAIN, 12(3), 295–302.
Vancouver
1.
Reyngoudt H, Paemeleire K, Dierickx A, Descamps B, Vandemaele P, De Deene Y, et al. Does visual cortex lactate increase following photic stimulation in migraine without aura patients?: a functional 1H-MRS study. JOURNAL OF HEADACHE AND PAIN. 2011;12(3):295–302.
MLA
Reyngoudt, Harmen, Koen Paemeleire, Anneloor Dierickx, et al. “Does Visual Cortex Lactate Increase Following Photic Stimulation in Migraine Without Aura Patients?: a Functional 1H-MRS Study.” JOURNAL OF HEADACHE AND PAIN 12.3 (2011): 295–302. Print.